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Twistronics is commonly applied to a twisted bilayer of two-dimensional materials. Here, authors introduce the concepts of twistronics to the superposition of two spin lattices generated from surface plasmon polaritons on a single surface. The system is periodically modulated by its total angular momentum.

Li-metal batteries often utilize liquid electrolytes that yield a solid–electrolyte interphase on electrodes; however, the role of anions in interphase formation remains unclear. Now it has been shown that anion-decomposition products provide varying contributions to interphase formation and that high-performance electrolytes balance effective interfacial passivation with minimized degradation.

The intricate, three-dimensional chain-walking of tertiary metal species has stood as a barrier to precision in migratory difunctionalization of multisubstituted alkenes. Now a sterically controlled chain recognition paradigm has been established, enabling highly selective head–tail carboboration and offering a streamlined route to natural products and functional materials.

METTL3 promotes healthy placenta function by regulating m⁶A methylation and histone epigenetics. Deficiency in METTL3 leads to premature senescence, inflammation activation of trophoblasts, contributing to pregnancy complications like preeclampsia.

Creating glycoside building blocks with multiple diversifiable positions from readily available sugar precursors remains a challenging task. Herein, the authors present a regio- and stereoselective nickel-catalyzed carboboration of glycals, which offers a platform for generating glycoside diversity with diverse C1 and C2 modification potential.

The study develops a rattle drum-inspired triboelectric nanogenerator with a charge dispatch strategy and structural design to enhance output. It achieves a triboelectric surface density of 2.76 cm^-1. Field tests show effective wave energy harvesting using a magnetic repulsion pendulum.

Electrochemical CO₂ reduction on copper-based catalysts under acidic conditions offers a promising solution to energy and environmental issues. Our study demonstrates that the yttrium-doped ZrO₂/CuO interface stabilizes Cu⁺ under harsh conditions, thereby enabling high selectivity toward ethylene.

Gate-all-around (GAA) nanosheet field-effect transistors (FETs) based on 2D semiconductors hold promise to complement silicon in future integrated circuits. Here, the authors report the wafer-scale growth of high-κ dielectric/semiconductor β-Bi₂SeO₅/Bi₂O₂Se/α-Bi₂SeO₅ heterostructures and their application for high performance 2D GAA FETs.

The transition metal-catalysed multicomponent cross-coupling of alkenes currently relies on strongly coordinating groups to direct the reactivity. Now Wu et al. present a nickel catalyst that enables the installation of sp² and sp³ fragments on alkenes using alcohols and ethers as directing groups.

Alkene 1,1-difunctionalization can provide direct access to valuable molecules. Now, an organometallic-radical relay strategy involving radical generation through homolysis of the metal–alkyl complex allows catalytic coupling of terminal or internal alkenes with arylboronic acids and electrophilic radical acceptors.

Osteoarthritis is closely linked to obesity. Here, the authors show that lipid overload in chondrocytes boosts fatty acid oxidation, fueling disease progression via SOX9 degradation and epigenetic dysregulation.

This study analyses how older adults across the USA access key services such as health care, food and housing, revealing geographic disparities and highlighting the need for more equitable planning as the population continues to age.

Using a thermal Rb-Xe hybrid spin maser the authors report the observation of a time crystal. The formation of time crystal is caused by a strong retarded interaction and the new oscillation frequency scales with the delay time characterized by the phase lag of the original oscillations.

Although COVID-19 vaccines are proving to be generally effective, new therapeutics to neutralize SARS-CoV-2 are required. Here, the authors engineer bispecific antibodies from ACE2-blocking B38 and H4 SARS-CoV-2 neutralizing antibodies and demonstrate their superiority in mice and nonhuman primates.

Analysing data from seven countries, this study found that unmarried individuals had a higher depression risk than married individuals. This risk was higher in Western countries, among males and among those with higher educational attainment.

Overcoming the suppressive tumor microenvironment (TME) is crucial to improving the efficacy of cancer therapy. Here the authors show that, in mouse cancer models, administration of exogenous IL-16 establishes a Th1-dominant TME via regulation of glutamine catabolism and triggers a Th1 cell-macrophage crosstalk, enhancing anti-tumor immune responses and the efficacy of immunotherapy.

Bladder cancer diagnosis lacks non-invasive biomarkers. Here, the authors discover urinary extracellular vesicle (EV) glycan signatures that distinguish bladder cancer patients from healthy controls, paving the way for EV-based liquid biopsy.

In the CRHCP-3 cluster-randomized trial, blood pressure reduction lowered the risk of all-cause dementia by 15% in 33,995 individuals with hypertension.

Pluripotent stem cells depend on specialized nuclear organization for their function. Here, the authors show that DDX18 regulates nucleolar phase separation and chromatin architecture to preserve human embryonic stem cell pluripotency.

Most applications of aggregation-induced emission luminogens (AIEgens) have been limited in small animal models. Here, the authors show the versatility of AIEgens-based imaging-guided surgical operation from small animals to rhesus macaque, in support of the clinical translation of AIEgens.

Multiple morphological abnormalities of the sperm flagella (MMAF) is a cause of male infertility. Here the authors identify homozygous nonsense mutations of the glutamine rich 2 (QRICH2) gene in two MMAF patients from 2 consanguineous families and show using QRICH2 knockout mice that the protein is required for sperm flagellar formation and motility.

Urban populations ebb and flow as the pulse of human mobility reshapes the cityscape. This paper shows a spatiotemporal scaling laws revealing hidden patterns in these dynamic shifts, linking them to the urban fabric’s structure, density, and functionality.

Achieving long-cycle-life, aqueous, dual-electrode-free Zn/MnO₂ batteries with high energy density is challenging. This work introduces a liquid crystal interphase in the electrolytes with soft templating effects, considerably enhancing performance.

Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combination immune checkpoint blockade, as well as delayed onset of immune-related adverse events across both treatment types, as well as delayed development of metastatic disease in seropositive patients.

Antibodies targeting OX40 or CD137, two T cell costimulatory receptors, have been shown to improve antitumor immunity. Here the authors design a phospholipid-derived nanoparticle to deliver OX40 or CD137 mRNA to T cells in vivo, improving efficacy of anti-OX40 and anti-CD137 antibody therapy in preclinical tumor models.

An array of chemically engineered CRISPR RNAs and AsCpf1 messenger RNAs leads to improvements in gene-cutting efficiency up to about 300% with respect to unmodified CRISPR RNA and plasmid-encoding AsCpf1.

The authors show that the deletion of ultraconserved TAD boundaries affects gene expression and phenotype, highlighting TAD evolution’s function. Human-specific TAD boundaries reveal a role in brain development and disease.

This work reports core–shell photovoltaic nanocells to enhance the photoresponse of the active layer and realize photolithographic manufacturing of large-scale-integrated organic phototransistors for high-resolution biomimetic vision.

Tetraspanin 8 (TSPAN8) has been implicated in a number of different tumours, but the underlying mechanisms remain unclear. Here, in breast cancer the authors highlight a role for TSPAN8 in promoting tumorigenesis through the activation of Hedgehog signalling.

Irvine and colleagues present a lipid nanoparticle platform containing self-replicating interleukin-12 RNA, which showed therapeutic efficacy in vivo by promoting immunogenic cell death and priming CD8⁺ T cells.

Kim et al. demonstrate neutrophil- and macrophage-enriched subtypes in triple-negative breast cancer and how these immune profiles affect therapeutic responses to immune checkpoint blockade.

Resequencing of 302 soybean accessions and GWAS provide a comprehensive resource for soybean geneticists and breeders.

The miRNA miR-3913-5p inhibits colorectal cancer cell proliferation, migration and invasion, in concert with its regulation of and by CREB5 and ATF2.

Adoptive transfer of macrophages, transfected with vitamin C lipid nanoparticles that deliver an antimicrobial peptide and cathepsin B mRNA, can be applied for the treatment of multidrug-resistant bacteria-induced sepsis in mice.