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Prime editing remains challenging in dicot plants. Here, authors developed FLICK-PE by adding two nicks flanking the target site, achieving high PE efficiency in soybean and tobacco. Using FLICK-PE, the authors developed a gene-edited glyphosate resistant soybean.

The irreversible sintering of Cu catalyst for deactivation remains a persistent challenge under thermal or photothermal reverse water-gas shift reaction process. Now, a hydroxyl-engineered CuNi nanocatalyst, derived from CuNiMgAl-LDH, achieves high and stable CO evolution under solar light by preventing sintering through dynamic hydroxyl anchoring of the nanoparticles.

Powdery mildew is a devasting disease for both common wheat and durum wheat. Here, the authors report the powdery mildew resistance locus derived from wild emmer wheat is conferred by the combined effect of two complementary nucleotide-binding and leucine-rich repeat genes.

Twinning is a powerful approach to engineering the physicochemical properties of metallic nanomaterials. Here, the authors discover unusual non-close-packed twinning planes in 4H-phase gold nanokites and show that they can be used as templates to grow 4H-phase twinned nanostructures of other noble metals.

Solid benzene and other simple organic minerals play important roles in geological processes on Titan-like cold Solar System bodies. Here, the authors discover benzene microcrystals plastically deform via densification enabled by molecule reorientation and shearing.

Maize kernels have long intrigued researchers due to their complex structure. Through microscopic sectioning and spatial transcriptomics, the authors observed the spatial distribution of RNA through electronic RNA in situ hybridization maps and discovered how storage accumulation occurs.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

AI models can extract clinical outcomes from electronic health records, but it is critical to ensure that such models preserve patient privacy. Here, the authors develop a teacher-student approach to produce shareable models for annotating cancer outcomes from imaging reports and oncologist notes while protecting patient privacy.

BHLHE40 promotes allergic asthma progression in mice via NRTN downregulation in macrophages, revealing a novel pathway in immune regulation.

Afatinib is a second-generation EGFR tyrosine kinase inhibitor recommended as the first-line treatment for patients with advanced EGFR mutant non-small cell lung cancer (NSCLC). Here the authors report the results of a phase II clinical trial of neoadjuvant afatinib for stage III EGFR mutant NSCLC.

Aumolertinib is a third generation EGFR tyrosine kinase inhibitors, approved for use in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 clinical trial investigating neoadjuvant aumolertinib in patients with unresectable stage III EGFR-mutant NSCLC.

Operando monitoring of thermal runaway in Li-ion batteries is critical. Here, authors develop an optical fiber sensor capable of insertion into 18650 batteries to monitor internal temperature and pressure during thermal runaway, facilitating battery safety assessment and early warning capability.

Under-liquid joining of metals has far-reaching implications for energy storage, space exploration, offshore mining and defense. Here, the authors report an alternative method to join metallic glasses firmly under water, seawater, flammable alcohol and even cryogenic liquid nitrogen.

The unconventional hexagonal phase CuCo PBA with open structure, large pore size, and high specific surface area is synthesized, and it delivers much better small molecular gas adsorption performance than the traditional cubic counterpart.

Identification of a broadly therapeutic antibody h1A6.2 against enteroviruses, which mimics the entry receptor SCARB2 and triggers monocyte/macrophage-dependent Fc effector functions in mice.

Induction-immunotherapy before surgery has been suggested for patients with unresectable stage III non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 umbrella clinical trial where patients with unresectable stage III NSCLC receive anti-PD1-based induction-therapy based on PD-L1 expression and contraindications to antiangiogenic therapy.

The authors report a stretchable tactile array with strain insensitivity, and a visual-tactile joint learning framework, achieving high-accuracy force measurement and replicating full states of hand and manipulated objects with fine-grained geometry.

Activation of the stimulator of interferon genes (STING) can induce immunity in various cancer therapies, but delivery of STING agonists to tumours is challenging. Now a metal-based polymeric nanoparticle delivers STING agonists to tumours upon disruption of endothelial cells in tumour vasculature and targets tumour-associated macrophages, eliciting anti-tumour immune response in hard-to-treat cancer models.

N6-methyladenine (6mA) DNA modification is a dynamic epigenetic mark in Drosophila embryos, but how 6mA is decoded is unclear. Here, the authors show that the protein Jumu binds 6mA-marked DNA to regulate the maternal-to-zygotic transition, partly through regulation the expression of the 6mA marked pioneer factor zelda.

Vascular smooth muscle cells (VSMCs) are known for their fate plasticity in atherosclerosis plaque progression. Here, Zhai et al. show that extracellular traps generated from CD68 ⁺ VSMCs adversely contribute to plaque progression and highlight their unexpected role in plaque stability by regulating the direction of VSMC trans-differentiation.

Intestinal microbiota alterations may affect heart function through the production of gut-derived metabolites. Here the authors found that gut microbiota-derived TMAVA is a key determinant for the development of cardiac hypertrophy through inhibition of carnitine synthesis and subsequent fatty acid oxidation.

Chen et al. examine the cellular necrosome using STORM and uncover the rod-shaped structure formed by mosaics of RIP1 and RIP3 oligomers.

Auxin induces transmembrane-kinase-dependent activation of H⁺-ATPase in the plasma membrane through phosphorylation of its penultimate threonine residue, promoting apoplastic acidification and hypocotyl cell elongation in Arabidopsis.

The product selectivity of photocatalytic carbon dioxide reduction from carbon monoxide to methane is determined by the active center from metal to sulfur site in metal sulfides. Non-metal sulfur in CuInSnS4 octahedral nanocrystal acts as carbon dioxide activation center for switching selectivity to methane.

Simultaneous achievement of lightweight and high strength is challenging. Here, authors combine self-assembly of nanoscale block copolymer and carbonization to create nanoporous amorphous carbon materials, which have the density of elastomers or plastic but the strength of metals or alloys.

The authors show a reductive interlayer structure that renders semi-transparent solar cells with a favourable combination of high efficiency and improved operational stability. When integrated in greenhouses, plant growth is comparable to that in the traditional glass-roof mode.

A wireless optoelectronic probe integrates a microscale light-emitting diode and a photodetector coated with oxygen-sensitive dyes to monitor the partial pressure of oxygen in the deep brain of freely moving mice.

The researchers fuse metamaterials and origami technical to achieve ultra-wideband and large-depth reflection modulation. Flexible electronics amplify its lightweight, transparency, and cost-effectiveness, making it ideal for satellite communications.

During transformation via Agrobacterium tumefaciens, sequence composition of T-DNA (that is, DNA repeats) affects T-DNA concatenation in Arabidopsis. In addition, loss of specific DNA repair proteins dramatically decreases T-DNA concatenation levels. This study showcases the potential of T-DNA concatenation as a tool to enhance gene editing.

A genome-wide association study in large cohorts of patients with different types of cancer treated with immune checkpoint inhibitors identifies genetic variants associated with immune-related adverse events.

The heteroepitaxial growth of crystalline 2D materials is usually based on single-crystal substrates. Here, the authors demonstrate that single-crystal graphene and hexagonal boron nitride films can be successfully grown on wafer-scale copper foils with tailored twin boundaries.

Circular RNAs are known to regulate cancer. Here, the authors show that the circular RNA circTP63 promotes lung squamous cell carcinoma by competing with endogenous RNA to upregulate FOXM1.

The 2024 Wushi earthquake ruptured an oblique-reverse network of subsidiary faults, which hosted the majority of aftershocks and generated surface rupture, while the mainshock did not, according to an analysis of local seismic, geodetic and field data.

Junin virus (JUNV) causes Argentine hemorrhagic fever and encodes the large protein (L) of the RNA dependent RNA polymerase (RdRp) and its regulator, the matrix zinc-binding protein (Z). Here, the authors present the 3.54 Å cryo-EM structure of the complex of JUNV L with Z, and they propose a model of how JUNV L is regulated by Z during the viral life cycle and RNA synthesis.

NLRC5 is known for its role in inflammation and antigen presentation. Here Luan et al. find that NLRC5 protects mice from intimal hyperplasia following vascular injury, and regulates the response of vascular smooth muscle cells to injury through direct interaction with PPARγ.

Scorpions have maintained the primary anatomical features of their Paleozoic arthropod ancestors. Here, the authors report the genome sequence of Mesobuthus martensiiand highlight evidence of genetic and morphological evolution that represents a unique adaptation model of arthropods.

A selective and potent CDK2 degrader was developed that induced differentiation of acute myeloid leukemia cell lines and primary patient cells.