Nature Search

On-surface synthesis of cyclo[20]carbon and cyclo[30]carbon from cyclo[10]carbon

On-surface synthesis recently enabled access to generate a series of cyclo[n]carbons via delicately designed precursors but for large cyclocarbons, synthesis of the corresponding precursors is challenging. Here, the authors report a strategy for synthesizing larger cyclocarbons via the coupling and ring-opening reactions from smaller ones.

Yuan Guo
Yuzhe Yun
Wei Xu
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 16, P: 1-8
The cumulenic linear C₅ and its coupling-reaction products

Linear carbon (Cn), an elusive sp hybridized carbon allotrope, has attracted much interest both experimentally and among theorists due to remarkable properties and significant controversy. Here, the authors report the synthesis and characterization of an uncapped linear C5 as well as longer even- and odd-numbered carbon chains.

Luye Sun
Yuan Guo
Wei Xu
ResearchOpen Access17 Oct 2025
Nature Communications

Volume: 16, P: 1-8
On-surface synthesis and characterization of linear and cyclic C₆

Linear C₆ and its isomer, cyclic C₆ (the smallest aromatic cyclocarbon), are successfully generated on NaCl surfaces by tip-induced dehalogenation of hexaiodobenzene molecules at 4.7 K, and their polyynic and cumulenic structures, respectively, are characterized by bond-resolved atomic force microscopy.

Luye Sun
Yuan Guo
Wei Xu
Research11 Apr 2025
Nature Synthesis

Volume: 4, P: 940-946
Meta-optics redefines microdisplay: monolithic color LCoS without polarization dependency

Liquid crystals on silicon (LCoS) devices are limited by the polarization sensitivity and reliance on complex architectures for full-color integration. Here, the authors demonstrate a metasurface-integrated LCoS device for polarisation-insensitive, full-color amplitude modulation on a single chip.

Xiangnian Ou
Yueqiang Hu
Huigao Duan
ResearchOpen Access08 Dec 2025
Nature Communications

Volume: 16, P: 1-10
Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome

Fan et al. describe DF-003, an alpha-kinase 1 (ALPK1) inhibitor that targets the root cause of the rare genetic disease ROSAH syndrome, demonstrating the ability of DF-003 to inhibit ocular inflammatory pathology in ROSAH model mice.

Jieqing Fan
Danyang Liu
Cong Xu
ResearchOpen Access09 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Association between mental health and MASLD molecular insights through metabolomics

Yang et al. conduct a prospective cohort study to investigate the association between mental health and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD). Anxiety, depression, mania, and trauma increase MASLD risk with metabolites related to nitrogen and lipid metabolism partially mediating this association.

Dashuai Yang
Nan Zhao
Wenzhi He
ResearchOpen Access27 Dec 2025
Communications Medicine

Volume: 6, P: 1-10
circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models

Aberrant circRNAs expression in repair cells is intricately linked to deficits in wound healing. Here, the authors engineered extracellular vesicles enriched with circCDK13 and demonstrate their ability to facilitate diabetic wound repair.

Qilin Huang
Ziqiang Chu
Cuiping Zhang
ResearchOpen Access09 May 2024
Nature Communications

Volume: 15, P: 1-18
Efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone: a multicenter, phase Ib/II study

Giant cell tumor of bone (GCTB) is a rare primary osteolytic bone tumor with high local recurrence rate after surgical resection. Here the authors conduct a phase Ib/II trial, evaluating the efficacy and safety of JMT103 (RANK-RANKL inhibitor) in patients with unresectable or surgically-challenging GCTB.

Hairong Xu
Yong Zhou
Xiaohui Niu
ResearchOpen Access05 Nov 2024
Nature Communications

Volume: 15, P: 1-9
The landscape of accessible chromatin in mammalian preimplantation embryos

An improved ATAC-seq approach is used to describe a genome-wide view of accessible chromatin and cis-regulatory elements in mouse preimplantation embryos, allowing construction of a regulatory network of early development that helps to identify key modulators of lineage specification.

Jingyi Wu
Bo Huang
Wei Xie
Research15 Jun 2016
Nature

Volume: 534, P: 652-657
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigenome and providing insights into how the maternal gene expression program transitions to the zygotic program.

Bingjie Zhang
Hui Zheng
Wei Xie
Research14 Sept 2016
Nature

Volume: 537, P: 553-557
The subcommissural organ regulates brain development via secreted peptides

The subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain substantially rescued developmental defects.

Tingting Zhang
Daosheng Ai
Woo-ping Ge
Research13 May 2024
Nature Neuroscience

Volume: 27, P: 1103-1115
Chromosome-level genome assembly and annotation of the kuruma shrimp Marsupenaeus japonicus

Yiming Wei
Hao Xu
Yong Mao
ResearchOpen Access12 Dec 2025
Scientific Data

Volume: 12, P: 1-9
Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting

Sensory detection of prey triggers hunting actions in predators. Zhao et al. show that the zona incerta integrates prey-related multisensory signals and induces a motivational drive to guide prey detection and promote predatory attack.

Zheng-dong Zhao
Zongming Chen
Wei L. Shen
Research24 May 2019
Nature Neuroscience

Volume: 22, P: 921-932
Accurate Inference of Local Phased Ancestry of Modern Admixed Populations

Yamin Ma
Jian Zhao
Qing Song
ResearchOpen Access23 Jul 2014
Scientific Reports

Volume: 4, P: 1-5
A preliminary exploration on DNA methylation of transgene across generations in transgenic rats

Qiling Li
Wei Xu
Qing Song
ResearchOpen Access06 Feb 2015
Scientific Reports

Volume: 5, P: 1-5
NAD⁺-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos

NAD⁺ deficiency impairing Sirt6 function reveals the mechanism of in vitro culture-induced telomere shortening in preimplantation embryos, providing a target to improve IVF outcomes.

Danjun Li
Wenzhi Li
Qifeng Lyu
ResearchOpen Access23 Aug 2025
Communications Biology

Volume: 8, P: 1-15
Using macromolecular electron densities to improve the enrichment of active compounds in virtual screening

Virtual screening methods for drug discovery typically rely on static structures and lack efficient incorporation of dynamic information exhibited in experimental electron densities. Here, the authors develop an approach utilizing multi-resolution experimental electron density maps to screen docking poses, with the effectiveness demonstrated in both the improvement of active compound enriching exhibited in the test using DUD-E data set and the identification of four inhibitors of Covid-19 3CLpro with IC50 of up to 1.9 μM.

Wenzhi Ma
Wei Zhang
Bo Huang
ResearchOpen Access22 Aug 2023
Communications Chemistry

Volume: 6, P: 1-12
IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells

Jifeng Yu
Song Li
Wenzhi Tian
ResearchOpen Access27 Dec 2022
Leukemia

Volume: 37, P: 695-698
PPA1 promotes NSCLC progression via a JNK- and TP53-dependent manner

Dehong Luo
Daishun Liu
Shuang Yang
ResearchOpen Access24 Sept 2019
Oncogenesis

Volume: 8, P: 1-13
Correction to: TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways

Wenzhi Shen
Renle Du
Rong Xiang
Amendments and CorrectionsOpen Access04 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-2
The aerobic diagenesis of Mesoproterozoic organic matter

Xiaomei Wang
Wenzhi Zhao
Emma U. Hammarlund
ResearchOpen Access06 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1

Qiankun Li
Wenzhi Hu
Cuiping Zhang
ResearchOpen Access13 Feb 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-13
Diverse vegetation responses to solar farm installation are also driven by climate change

Vegetation responses to solar farm installations are often attributed to the altered microclimates, but climate change also determines habitat changes and vegetation growth, according to an analysis that uses satellite data of enhanced vegetation index and harmonic regression model.

Chuandong Wu
Hu Liu
Dawen Yang
ResearchOpen Access17 Feb 2025
Communications Earth & Environment

Volume: 6, P: 1-9
Unveiling the association between HMG-CoA reductase inhibitors and bladder cancer: a comprehensive analysis using Mendelian randomization, animal models, and transcriptomics

Houyi Wei
Zhilong Li
Xinghuan Wang
Research07 Aug 2024
The Pharmacogenomics Journal

Volume: 24, P: 1-12
Correction: Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

Cheng Wei
Yibin Pan
Songying Zhang
Amendments and CorrectionsOpen Access30 Oct 2020
Cell Death & Disease

Volume: 11, P: 1
Correction to: Bone mesenchymal stem cell-derived extracellular vesicles containing NORAD promote osteosarcoma by miR-30c-5p

Hongtao He
Muliang Ding
Wei Zhang
Amendments and Corrections19 Apr 2022
Laboratory Investigation

Volume: 102, P: 1160-1161
Correction: PPA1 promotes NSCLC progression via a JNK- and TP53-dependent manner

Dehong Luo
Daishun Liu
Shuang Yang
Amendments and CorrectionsOpen Access13 Dec 2019
Oncogenesis

Volume: 8, P: 1-3
MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3

Wei Liu
Dexin Shen
Xinghuan Wang
Research07 Sept 2022
Oncogene

Volume: 41, P: 4606-4617
Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase

A study on bladder cancer indicates that Parkin influences bladder cancer progression and metastasis by regulating cellular ROS levels through ubiquitin-mediated proteasomal degradation of Catalase, rather than its autophagic function.

Renjie Zhang
Wenyu Jiang
Xinghuan Wang
ResearchOpen Access29 Feb 2024
Communications Biology

Volume: 7, P: 1-16
Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

Cheng Wei
Yibin Pan
Songying Zhang
ResearchOpen Access15 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-15
Efficacy and safety of focused low-intensity pulsed ultrasound versus pulsed shortwave diathermy on knee osteoarthritis: a randomized comparative trial

Lang Jia
Dongqian Li
Wenzhi Chen
ResearchOpen Access27 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

J. Yuyang Lu
Lei Chang
Xiaohua Shen
ResearchOpen Access29 Jan 2021
Cell Research

Volume: 31, P: 613-630
Case control study comparing the HPV genome in patients with oral cavity squamous cell carcinoma to normal patients using metagenomic shotgun sequencing

Ian Ganly
Zhiheng Pei
Liying Yang
ResearchOpen Access16 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
Bone mesenchymal stem cell-derived extracellular vesicles containing NORAD promote osteosarcoma by miR-30c-5p

NORAD, a non-coding RNA activated by DNA damage, is highly expressed in osteosarcoma cells and tissue. The authors show that extracellular vesicles (EVs) derived from bone mesenchymal stem cells (BMSCs) deliver NORAD to osteosarcoma cells to regulate the miR-30c-5p/ Krueppel-like factor 10 axis, thereby accelerating the progression and metastasis of osteosarcoma.

Hongtao He
Muliang Ding
Wei Zhang
Research24 Mar 2022
Laboratory Investigation

Volume: 102, P: 826-837
TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness

Renle Du
Wenzhi Shen
Yunping Luo
ResearchOpen Access13 Dec 2019
Signal Transduction and Targeted Therapy

Volume: 4, P: 1-12
TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways

Wenzhi Shen
Renle Du
Rong Xiang
ResearchOpen Access22 Jul 2016
Signal Transduction and Targeted Therapy

Volume: 1, P: 1-10
PKCζ phosphorylates TRAF2 to protect against intestinal ischemia–reperfusion–induced injury

Wei Zhou
Jihong Yao
Xiaofeng Tian
ResearchOpen Access20 Jul 2017
Cell Death & Disease

Volume: 8, P: e2935

Search

On-surface synthesis of cyclo[20]carbon and cyclo[30]carbon from cyclo[10]carbon

The cumulenic linear C₅ and its coupling-reaction products

On-surface synthesis and characterization of linear and cyclic C₆

Meta-optics redefines microdisplay: monolithic color LCoS without polarization dependency

Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome

Association between mental health and MASLD molecular insights through metabolomics

circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models

Efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone: a multicenter, phase Ib/II study

The landscape of accessible chromatin in mammalian preimplantation embryos

Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

The subcommissural organ regulates brain development via secreted peptides

Chromosome-level genome assembly and annotation of the kuruma shrimp Marsupenaeus japonicus

Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting

Accurate Inference of Local Phased Ancestry of Modern Admixed Populations

A preliminary exploration on DNA methylation of transgene across generations in transgenic rats

NAD⁺-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos

Using macromolecular electron densities to improve the enrichment of active compounds in virtual screening

IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells

PPA1 promotes NSCLC progression via a JNK- and TP53-dependent manner

Correction to: TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways

The aerobic diagenesis of Mesoproterozoic organic matter

MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1

Diverse vegetation responses to solar farm installation are also driven by climate change

Unveiling the association between HMG-CoA reductase inhibitors and bladder cancer: a comprehensive analysis using Mendelian randomization, animal models, and transcriptomics

Correction: Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

Correction to: Bone mesenchymal stem cell-derived extracellular vesicles containing NORAD promote osteosarcoma by miR-30c-5p

Correction: PPA1 promotes NSCLC progression via a JNK- and TP53-dependent manner

MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3

Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase

Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

Efficacy and safety of focused low-intensity pulsed ultrasound versus pulsed shortwave diathermy on knee osteoarthritis: a randomized comparative trial

Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

Case control study comparing the HPV genome in patients with oral cavity squamous cell carcinoma to normal patients using metagenomic shotgun sequencing

Bone mesenchymal stem cell-derived extracellular vesicles containing NORAD promote osteosarcoma by miR-30c-5p

TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness

TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways

PKCζ phosphorylates TRAF2 to protect against intestinal ischemia–reperfusion–induced injury

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