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Showing 1–17 of 17 results
Advanced filters: Author: Wesley C Van Voorhis Clear advanced filters

  • Here, a library of more than 300,000 chemicals was screened for activity against Plasmodium falciparum growing in red blood cells. Of these chemicals, 172 representative candidates were profiled in detail; one exemplar compound showed efficacy in a mouse model of malaria. The findings provide the scientific community with new starting points for drug discovery.

    • W. Armand Guiguemde
    • Anang A. Shelat
    • R. Kiplin Guy
    Research
    Nature
    Volume: 465, P: 311-315

  • The SARS-CoV-2 PANGO lineage C.1.2 has been under monitoring by global health authorities as it has spread worldwide. Here, Bhiman and colleagues characterise the emergence of the lineage, and its neutralisation sensitivity using data from vaccinees and previously infected individuals.

    • Cathrine Scheepers
    • Josie Everatt
    • Jinal N. Bhiman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Andrade, Adelino, Fonseca et al. used phylogenetic, phylogeographic, and temporal approaches to track yellow fever viral transmission across forestry, rural, and urban areas of Brazil. All genomes belong to the South American lineage, with one Amazon cluster showing hidden persistence and another in the southeast indicating reintroduction and sustained transmission.

    • Valnete das Graças Dantas Andrade
    • Talita Émile Ribeiro Adelino
    • Luiz Carlos Junior Alcantara
    ResearchOpen Access
    Communications Medicine
    Volume: 6, P: 1-6

  • Chikungunya virus is endemic in Brazil and cases have been rapidly increasing in recent years. Here, the authors describe the expansion of a genomic surveillance program across the country allowing them to characterise the emergence and dispersal of two distinct subclades mainly seeded from the north eastern region.

    • Joilson Xavier
    • Luiz Carlos Junior Alcantara
    • Marta Giovanetti
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The wealth of genomic data for pathogens that cause tropical diseases hold considerable promise for the discovery of novel drugs. An international consortium describes how the TDR Targets database integrates this data with related biochemical and pharmacological data to facilitate the identification and prioritization of drug targets.

    • Fernán Agüero
    • Bissan Al-Lazikani
    • Christophe L. M. J. Verlinde
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 900-907

  • Despite considerable advances in malaria medicines in the past 20 years, the global burden of malaria remains substantial. Moreover, continued emergence of drug resistance ensures that new antimalarials will be needed in the near future. Wells and colleagues summarize the current landscape of antimalarial therapies and investigational drugs, highlighting the progress made, identifying gaps in terms of target profiles and recommending priorities for future research.

    • Timothy N. C. Wells
    • Rob Hooft van Huijsduijnen
    • Wesley C. Van Voorhis
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 424-442

  • A family of calcium-dependent protein kinases (CDPK) is present in apicomplexan parasites but not in animals, indicating their potential as targets for anti-parasitic drugs. Structural and functional studies on Toxoplasma gondii CDPK1 now reveal that this kinase is sensitive to a class of drugs called bumped kinase inhibitors, which can inhibit the parasite's growth and host cell invasion.

    • Kayode K Ojo
    • Eric T Larson
    • Wesley C Van Voorhis
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 602-607

  • Malaria is a mosquito-transmitted infection that affects more than 200 million people worldwide, with the highest morbidity and mortality in Africa. Elimination, through vector control approaches and chemoprevention, is within reach, but is threatened by the emergence of drug-resistant strains of mosquitoes and Plasmodium spp., the infectious parasite.

    • Margaret A. Phillips
    • Jeremy N. Burrows
    • Timothy N. C. Wells
    Reviews
    Nature Reviews Disease Primers
    Volume: 3, P: 1-24

  • The emergence of drug-resistantPlasmodiumparasites has made the treatment of malaria difficult in some areas. One of the last drugs to which there is no full resistance is artemisinin. Fidock and Eastman describe artemisinin-based combination therapies that aim to decrease the occurrence of drug resistance and that have raised the possibility of malaria eradication.

    • Richard T. Eastman
    • David A. Fidock
    Reviews
    Nature Reviews Microbiology
    Volume: 7, P: 864-874