Although the stereochemistry of nickel hydride addition to alkenes is well-explored, the analogous addition to another feedstock, alkynes, is less studied. Here the authors develop a regio- and enantioselective hydroalkylation of alkynes to produce chiral allylic amines, proceeding via migratory insertion of a nickel–alkyl species into an alkyne pi bond.
- Qian Gao
- Wei-Cheng Xu
- Xi-Sheng Wang
