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Volumetric Localization Microscopy (VLM) integrates light-field imaging with deep learning for high-fidelity 3D single-molecule imaging. Trained on system-aware PSFs, VLM offers simple, efficient, low-toxicity 3D imaging for biomedical research.

Dinuclear gold complexes have fundamentally expanded catalytic possibilities beyond that of the mononuclear systems. Here the authors report a bidentate mixed-ligand system that can catalyze efficient three-component carbonylative amidation of unactivated alkyl bromides with amines and CO under mild conditions.

Balancing power conversion efficiency and mechanical robustness in flexible electronics remains challenging. Here, the authors introduce 1,3,5-tris(bromomethyl)benzene into polymer donors as a crosslinker to improve the devices’ flexibility while achieving 20.48% efficiency in ternary organic solar cells.

A project that intertwines data on weather, water flow and energy demand to create a 3D model of the whole river basin would enable researchers and others to make water-management decisions in real time.

Here, the authors identify a copy number variation containing three enhancers (PIHEC) that drives bilateral constricted ear by co-ordinately regulating HMX1 expression, revealing how aberrant Hmx1 expression in neural crest-derived fibroblasts disrupts outer ear development.

Advancements in proton-exchange membrane water electrolyzers rely on developing oxygen evolution reaction catalysts with high activity and stability. Here, the authors report a method to enhance the spatiotemporal coordination of oxygen radicals in a Ru-based catalyst for improved performance.

Lithium metal battery performance is optimized using a delocalized electrolyte design that induces a disordered solvation microenvironment, thereby combining the advantages of the solvent-dominated and anion-dominated structures of conventional electrolytes.

DeepSeMi is a self-supervised denoising framework that can enhance SNR over 12 dB across diverse samples and imaging modalities. DeepSeMi enables extended longitudinal imaging of subcellular dynamics with high spatiotemporal resolution.

Spatial omics technologies require alignment and stitching of slices for a 3D molecular profile. Here, the authors present SANTO, a coarse-to-fine method that rapidly determines spatial positions and overlap regions, then refines them, enabling integration across platforms and modalities.

Multifunctional all-optical logic gate (AOLG) with broadband-based massively parallel processing is desirable for high-speed optical processor. Here, authors propose a reconfigurable all-in-one ultra-broadband AOLG with experimentally achieving 9 fundamental Boolean logics in a single configuration.

While perovskite solar cells with an inverted architecture hold great promise for operation stability, their power conversion efficiency lags behind that of conventional cells. Here, Zheng et al. achieve a certified 22.34% efficiency, exploiting alkylamine ligands as grain and interface modifiers.

Atomically dispersed metallic materials attract tremendous attention. Here the authors explore a general method based on the discrepancy in cohesive energy of the metals to synthesize a large library of bi-/multi-metallic single atom/atomic cluster materials for electrocatalytic hydrogen evolution.

While heat modification is ubiquitous in biologic systems, it remains a significant challenge in artificial systems. Here the authors demonstrate thermal regulation of conversion between different rigid macrocycle atropisomers and related self-assemblies.

It is challenging to synthesize cobalt manganese spinels with controlled phase and composition. Here the authors present a solution-based synthesis method for the spinels, which show potential in catalysing oxygen reduction reactions.

Cereal crops' grain yield and quality are traits that are usually considered to be negatively correlated. Here, the authors show that interaction of G-protein βγ subunits with an alternatively spliced MADS1^lgy3 protein can increase rice grain yield and quality simultaneously in field conditions.

Low energy density and limited cyclability are preventing the commercialization of aqueous Zn–MnO₂ batteries. Here, the authors combine the merits of operating Zn anodes in alkaline conditions and MnO₂ cathodes in acidic conditions, via an electrolyte-decoupling strategy, to realize high-performance batteries.

The authors here report a sunlight-promoted rechargeable zinc–air battery in which photoelectrode is used as the air electrode to substantially lower the charge potential under illumination. Notably, the battery can be initially charged with an extremely low voltage of ~1.20 V.

Mechanically interlocked molecules are extensively applied as artificial molecular machines but rotaxane-branched dendrimers are rarely explored because of synthetic challenges. Here the authors present the construction of dual stimuli-responsive rotaxane-branched dendrimer which can be stimulated by DMSO or acetate ions.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

In photonic crystal systems, topologically protected edge states and corner states can be achieved by breaking spatial inversion symmetry. The authors propose a broadband valley photonic crystal with a relative bandwidth up to 59.65%, demonstrating ultrabroadband topological transmission and two types of corner states with valley switch ability and selectivity.

Barrett’s oesophagus—a metaplasia that can be induced by persistent acid reflux, and predisposes patients to oesophageal cancer—arises from a population of basal cells at the gastro-oesophageal junction.

Vegetation vulnerability during compound drought and heatwave events has shifted spatially over recent decades, and is expected to increase significantly in the future, but vegetation resistance can mitigate these changes, according to an analysis of vegetation indices and model simulations.

Tumor–normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking ‘tumor-only’ or ‘matched tumor–normal’ analyses.

Molybdenum-based electrocatalysts are widely investigated as water splitting catalysts but they suffer from low efficiency due to surface oxidation. Here the authors report the synthesis of air-stable molybdenum nitride which displays enhanced hydrogen evolution activity.