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Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential

Phospholipid remodeling governs cell fate, yet its ferroptosis-related mechanisms remain elusive. Here, we report the cryo-EM structure of phospholipid remodeler TMEM164, identify its lipid remodeling mechanism, and discover Montelukast S- enantiomer as a potent inhibitor.

Minjing Ke
Yuanyue Shan
Duanqing Pei
ResearchOpen Access20 Dec 2025
Nature Communications

Volume: 17, P: 1-13
Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Chu-Yi Zhang
Miao Li
Ming Li
Research25 Nov 2025
Nature Neuroscience

P: 1-13
Tracking grid-level freshwater boundary exceedance along global supply chains from consumption to impact

Global consumption drives freshwater overuse at production sites along supply chains, of which 24% is outsourced via trade. Agricultural demand is a key driver, while manufacturing exports exacerbate water stress in emerging economies.

Siyu Hou
Jingwen Huo
Klaus Hubacek
ResearchOpen Access07 Apr 2025
Nature Water

Volume: 3, P: 439-448
Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images

Deep-learning models trained on retinal fundus images can be used to identify chronic kidney disease and type 2 diabetes and to predict the risk of the progression of these diseases.

Kang Zhang
Xiaohong Liu
Guangyu Wang
Research15 Jun 2021
Nature Biomedical Engineering

Volume: 5, P: 533-545
Glutathione triggers leaf-to-leaf, calcium-based plant defense signaling

Li et al. identified GSH as a signaling molecule that triggers wound-induced systemic [Ca^2 +]_cyt transmission, activates JA biosynthesis, and regulates plant defense responses, highlighting the complex mechanisms of plant systemic defense signaling.

Rui Li
Yongfang Yang
Daoxin Xie
ResearchOpen Access24 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Effects of Lacticaseibacillus rhamnosus MP108 on functional constipation symptoms and gut microbiota in children

Caixia Peng
Yunfeng Pan
Qian Lin
Research10 Jan 2026
Pediatric Research

P: 1-11
Landscape of pathogenic mutations in premature ovarian insufficiency

Whole-exome sequencing analyses in a cohort of 1,030 patients with premature ovarian insufficiency identify new likely pathogenic variants and reveal distinct genetic architectures between primary and secondary amenorrhea.

Hanni Ke
Shuyan Tang
Zi-Jiang Chen
ResearchOpen Access02 Feb 2023
Nature Medicine

Volume: 29, P: 483-492
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
Red blood cell distribution width to albumin ratio as a predictor of mortality in ICU patients with community acquired bacteremia

Xiaoxi Shan
Jing Jiang
Lixia Dong
ResearchOpen Access19 Nov 2024
Scientific Reports

Volume: 14, P: 1-12
FetalQuant^SD: accurate quantification of fetal DNA fraction by shallow-depth sequencing of maternal plasma DNA

Peiyong Jiang
Xianlu Peng
Kwan Chee Allen Chan
ResearchOpen Access11 May 2016
npj Genomic Medicine

Volume: 1, P: 1-7
Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation

Dan-Yun Ruan
Hao-Xiang Wu
Rui-Hua Xu
ResearchOpen Access17 Jun 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-9
Differentially localized protein identification for breast cancer based on deep learning in immunohistochemical images

Six differentially localized proteins are obtained through protein subcellular localization prediction models constructed by deep learning in immunohistochemical images, providing support for breast cancer early diagnosis and treatment.

Zihan Zhang
Lei Fu
Wan Li
ResearchOpen Access02 Aug 2024
Communications Biology

Volume: 7, P: 1-13
Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Liting Chen
Xiaolu Long
Jianfeng Zhou
Correspondence03 Jul 2020
Cellular & Molecular Immunology

Volume: 17, P: 992-994

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Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential

Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery

Tracking grid-level freshwater boundary exceedance along global supply chains from consumption to impact

Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images

Glutathione triggers leaf-to-leaf, calcium-based plant defense signaling

Effects of Lacticaseibacillus rhamnosus MP108 on functional constipation symptoms and gut microbiota in children

Landscape of pathogenic mutations in premature ovarian insufficiency

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Red blood cell distribution width to albumin ratio as a predictor of mortality in ICU patients with community acquired bacteremia

FetalQuant^SD: accurate quantification of fetal DNA fraction by shallow-depth sequencing of maternal plasma DNA

Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation

Differentially localized protein identification for breast cancer based on deep learning in immunohistochemical images

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

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