Transition-metal-catalyzed hydroarylation is pivotal for selective carbon–carbon bond formation, but achieving high product selectivity remains challenging. In this study, the authors report a nickel-catalyzed ß-arylation and benzylation of 2′-hydroxychalcone, enabled by the substrate’s intrinsic hydroxy group, to efficiently synthesize chalcone derivatives that can be transformed into potent anticoagulant agents.
- Bo-Cheng Tang
- Xiaochun Su
- Cong Ma
