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The emission of photons by excited nuclei has been explored for timekeeping and sensing, but nuclear processes that eject electrons offer practical advantages.

Dimensional regulation of 2D perovskites remains challenging due to progressive phase transitions in solution-based processes. Now a non-invasive surface reaction strategy enables the formation of phase-pure 2D perovskite contact layers, boosting the efficiency and stability of perovskite solar cells and modules.

Semiconductor quantum dots that simultaneously support blue and yellow emission offer a route to realizing efficient white light-emitting diodes.

Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV induce ALS-like phenotypes in rats and highlight CIV deficiency as a potential risk factor and therapeutic target for ALS.

Base editing technologies predominantly utilize engineered deaminases for cytosine and adenine. Here, the authors achieve efficient, specific, and low-toxicity base editing of thymine by engineering Deinococcus radiodurans uracil-DNA glycosylase.

Hypertension is the leading risk factor for cardiovascular disease, which represents the top cause of morbidity and mortality worldwide. Here, the authors show deletion of endothelial Sp1 and Sp3 leads to a disruption in endothelium-dependent vasodilation and the onset of hypertension, which abolishes the beneficial actions of captopril.

The clinical application of inhibitors targeting checkpoint kinase 1 (CHK1) is challenged by limited efficacy. Here, the authors identify that thioredoxin (Trx) system inhibition mediates sensitivity to CHK1 inhibitor via regulating the activity of ribonucleotide reductase, demonstrating the synergistic effect of CHK1 inhibitor and inhibitors targeting Trx system in lung cancer models.

Achieving long-cycle-life, aqueous, dual-electrode-free Zn/MnO₂ batteries with high energy density is challenging. This work introduces a liquid crystal interphase in the electrolytes with soft templating effects, considerably enhancing performance.

Wang and colleagues generate two protein-level mutant p53 reporters and use them to identify precancerous clones in normal tissues in vivo, characterized by increased amino acid metabolism and a transcriptomic signature that includes Ybx3.

Lake surface water temperatures have increased over recent decades, mainly driven by atmospheric conditions. Here the authors demonstrate that heat events drive a disproportionately large part of this lake surface warming and increases in lake heatwaves.

Indicine cattle make up half of all cattle populations worldwide. Using a large genomic dataset, this study finds historic migrations and extensive introgression with domestic and wild bovine species has facilitated this species physiological adaptation to extreme environments.

The epigenetic program underlying the differentiation of innate lymphoid cell precursors (ILCPs) into innate lymphoid cell (ILC) subsets remains poorly understood. Here the authors show genome-wide distribution of the DNA methylation and hydroxymethylation in murine ILC subsets and at postnatal stage, gut microbiota contributes to the downregulation of TET1 level, resulting in an expansion of ILC1s.

Diagnosis of lung cancer from indeterminate pulmonary nodules remains challenging. Here, the authors develop a multi-omics signature to identify oncogenic nodules, and prevent unnecessary procedures.

Host defense against helminth infection is mediated by mucosal type 2 immunity. Using gain- and loss-of-function mouse models, and mouse intestinal organoids, Xiong et al. show that SIRT6 modulates tuft and goblet cell expansion in intestinal epithelium by activating STAT6 to maintain type 2 mucosal immunity in response to helminth infection.

Heat extremes occur more frequently with global warming. Here the authors show that short-term heat extremes play a critical role in shaping long-term dynamics of lake surface temperature, contributing 36.5% of the warming trends in Chinese lakes.

Disulfiram is an FDA-approved drug for treating alcoholism. Wu and colleagues show that disulfiram can be repurposed to efficiently inhibit pyroptosis by specifically blocking gasdermin-mediated pore formation.

This study shows that lake heating in response to atmospheric warming slows as surface waters warm and evaporate. Lake sensitivity to warming air is higher in clear, cold, undisturbed, or elevated lakes, but declines when land-use practices fertilize basins.

Resonant X-ray excitation of the  ⁴⁵Sc nuclear isomeric state was achieved by irradiation of a Sc-metal foil with 12.4-keV photon pulses from a state-of-the-art X-ray free-electron laser, allowing a high-precision determination of the transition energy.

Direct methanol fuel cells are promising for clean, sustainable energy, but catalysts should be optimized. Here the authors construct ultrathin nanoframes with rich crystalline defects to increase electrocatalytic activity of gold for methanol oxidation, which is surprisingly promoted by carbon monoxide.

Water oxidation is key to the production of chemical fuels from electricity. Now, guided by theory, NiCoFeP oxyhydroxide catalysts have been developed that require an overpotential lower than that required by IrO₂. In situ soft X-ray absorption studies of neutral-pH NiCoFeP catalysts indicate formation of Ni⁴⁺, which is favourable for water oxidation.

Photoproduction of solar fuels and important chemicals is of significant interest. Here, the authors construct a cobalt single atom-based photothermal-photocatalytic heterostructure that realizes efficient hydrogen peroxide photosynthesis from earth-abundant seawater.

Gate-tunable heterojunction diodes—or triodes—that are based on van der Waals heterostructures formed from two-dimensional indium selenide and three-dimensional silicon can exhibit subthreshold slopes of 6.4 mV decade^–1 and on-state current densities of 0.3 µA µm^–1 at a drain bias of –1 V.

A stretchable anode, cathode, semiconductor and current collector have been developed to create stretchable diodes that can operate at megahertz frequencies for use in wirelessly operated, skin-like wearable electronics.

The electrocatalytic upgrading of CO to higher-value fuels provides a promising route to multi-carbon alcohol products. Here, the authors show that high alcohol selectivity and activity can be achieved by incorporating palladium in copper.

Single-atom catalysts are receiving much attention, but insights into their active sites or the differences in reactivity with conventional nanoparticles are still controversial. Now, operando studies on CO oxidation with Ir/MgAl₂O₄ accompanied by computational investigations reveal important features of this class of catalyst.

Haematopoiesis and the generation of lymphoid cell subsets are controlled by delicate genetic programs enforced via epigenetic regulation. Here the authors show that Pcid2 interacts with ZNHIT1, a component of the SRCAP chromatin remodelling complex, to critically modulate the differentiation of multipotent progenitors.

The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging.

Spin-polarized photon absorption and photoluminescence are reported in reduced-dimensional chiral perovskite materials. The finding indicates that such materials may in the future be useful as a photonic interface for spintronics.

A strategy for managing the compositional distribution in metal halide perovskite light-emitting diodes enables them to surpass 20% external quantum efficiency—a step towards their practical application in lighting and displays.