Nature Search

Large-scale biosynthetic analysis of human microbiomes reveals diverse protective ribosomal peptides

Here, by analyzing 306481 microbial genomes from human-associated microbiomes, the authors reveal a largely unexplored biosynthetic landscape of ribosomal peptides (RiPPs), identifying protective peptides that obstruct pathogen biofilms and regulate gut microbiota in disease models, underscoring their significant therapeutic potential.

Jian Zhang
Dengwei Zhang
Yong-Xin Li
ResearchOpen Access28 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Intrinsic cleavage of RNA polymerase II adopts a nucleobase-independent mechanism assisted by transcript phosphate

Cell viability depends on transcriptional fidelity, but the proofreading mechanism of eukaryotic RNA polymerase II (Pol II) remained elusive. Now, Cheung, Wang, Zhang, Huang and co-workers show that Pol II utilizes the downstream phosphate oxygen of the RNA transcript to activate intrinsic cleavage of misincorporated nucleotides.

Carmen Ka Man Tse
Jun Xu
Xuhui Huang
Research11 Feb 2019
Nature Catalysis

Volume: 2, P: 228-235
Enhanced energy storage performance in NBT-based MLCCs via cooperative optimization of polarization and grain alignment

Grain alignment and polarization engineering were simultaneously utilized to enhance the energy storage performance of Na_1/2Bi_1/2TiO₃-based multilayer ceramic capacitors, leading to an energy density of 15.7 J·cm⁻³ and energy efficiency over 95%.

Yang Li
Ningbo Fan
Fei Li
ResearchOpen Access17 Oct 2024
Nature Communications

Volume: 15, P: 1-11
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
An interpretable machine learning model predicts the interactive and cumulative risks of different environmental chemical exposures on depression

Gang Luo
Wei Xu
Kefeng Li
ResearchOpen Access31 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-10
Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes

Wang et al. examine the sex-specific associations of intrapancreatic fat deposition (IPFD) with incident type 2 diabetes (T2D) using the UK biobank cohort. IPFD is associated with incident T2D independent of BMI, hepatic fat and visceral fat in men and independent of BMI and hepatic fat in women.

Xuechen Wang
Yucheng Yang
Yuxiu Li
ResearchOpen Access28 Nov 2025
Communications Medicine

Volume: 5, P: 1-7
MDSC checkpoint blockade therapy: a new breakthrough point overcoming immunosuppression in cancer immunotherapy

Abdulrahman Ibrahim
Nada Mohamady Farouk Abdalsalam
Dehong Yan
ReviewsOpen Access26 Mar 2025
Cancer Gene Therapy

Volume: 32, P: 371-392
Retinol Binding Protein-4 Levels and Non-alcoholic Fatty Liver Disease: A community-based cross-sectional study

Xuechen Chen
Tianran Shen
Yu-ming Chen
ResearchOpen Access23 Mar 2017
Scientific Reports

Volume: 7, P: 1-8
Plant adenylate cyclases have come full circle

This Perspective presents an historical overview and recent advances on adenylate cyclases (ACs) and cAMP signalling in plants, including an exploration of the active AC functions moonlighting within multifunctional protein complexes.

Aloysius Wong
Wei Chi
Chris Gehring
Reviews14 Sept 2023
Nature Plants

Volume: 9, P: 1389-1397
The application of deep learning based diagnostic system to cervical squamous intraepithelial lesions recognition in colposcopy images

Chunnv Yuan
Yeli Yao
Weiguo Lu
ResearchOpen Access15 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Strigolactones positively regulate abscisic acid-dependent heat and cold tolerance in tomato

Cheng Chi
Xuechen Xu
Jingquan Yu
ResearchOpen Access01 Nov 2021
Horticulture Research

Volume: 8, P: 1-15
Integrated phosphoproteomic and metabolomic profiling reveals perturbed pathways in the hippocampus of gut microbiota dysbiosis mice

Haiyang Wang
Lanxiang Liu
Peng Xie
ResearchOpen Access13 Oct 2020
Translational Psychiatry

Volume: 10, P: 1-12
Towards a tailored indoor horticulture: a functional genomics guided phenotypic approach

Claudius Marondedze
Xinyun Liu
Aloysius Wong
ReviewsOpen Access01 Nov 2018
Horticulture Research

Volume: 5, P: 1-10

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