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Co-fractionation mass spectrometry reveals protein interactions but is low throughput and data-limited. Here, the authors present ProteoAutoNet, a robotic platform integrated with machine learning that doubles sample processing throughput and predicts thousands of co-eluted protein interactions in thyroid cancer cells, revealing disease-relevant complexes like upregulated proteasome, prefoldin, and a predicted HK1-TGM2 interaction.

Here, authors use Cryo-FIB and Cryo-TEM to reveal the atomic structures of the sulfide electrolyte/Si electrode interfaces, showing that the continuous lithium-ion consumption during interfacial reaction rather than interface impedance leads to capacity fade and battery failure.

The authors leverage a super-bunching light to develop a spectrally encoded parallel LiDAR that achieves crosstalk-free optical channel division and supports effective long-range detection beyond conventional pulse-period limitations without requiring additional encoding or decoding.

The pursuit of all-solid-state batteries has motivated advancements in materials design. Here, the authors present a methodology demonstrating that ionic potential effectively captures crucial interactions within halide materials, guiding the design of the new materials with enhanced performance.

Prostate cancer diagnosis require MRI analysis, however, scoring can vary between clinicians. Here, the authors develop ProAI to detect prostate cancer from imaging.

A bonding and debonding strategy is used to stack epitaxially grown semiconductor monolayers into various structures with precise control of the layer number and interlayer twist angle.

DNA computing systems face challenges in switching functions due to complex molecular redesigns. Here, the authors introduce a base Stacking-Mediated Allostery (SMALL) strategy enabling efficient function switching with minimal architecture changes (1-2 nucleotides), implemented across diverse logic operations and cellular gene regulation patterns.

The introduction of chemical short-range disorder substantially affects the crystal structure of layered lithium oxide cathodes, leading to improved charge transfer and structural stability.

Electrolytes, function as an ion conducting membrane between battery electrodes, are essential for rechargeable batteries. Here, the authors report high-entropy liquid electrolytes and reveal substantial impact of the increasing entropy on lithium-ion solvation structures for highly reversible lithium batteries.

The authors manipulate two categories of cathodes for sodium-ion batteries for a rational design that combines high energy density with high power density and long cycling life.

Male breast cancer may involve different populations of immune cells. Here the authors use single cell transcriptomics to show that infiltration of T cells is lower in male breast cancer relative to female breast cancer, and find that this is accompanied by distinct metabolic changes.

One-dimensional materials such as carbon nanotubes have many applications, but not all of their properties can be described in the same way as for conventional media. Here, the authors devise a method to measure the complex optical susceptibility in a 1D nanomaterial and demonstrate it for carbon nanotubes.

Field-effect transistors with good electrical performance at room temperature are fabricated from few-layer black phosphorus.

Crumpled graphene structures are promising for electrochemical energy storage. Here, the authors synthesize deeply crumpled pinecone-like graphene sheets, which show self-adaptive folding-unfolding behaviours in cycling leading to robust battery performances.

Efficient hot electron extraction from plasmonic structures is often limited by interface quality. Here, the authors report that spinodal decomposition can produce coherent metal/semiconductor heterostructures that enable efficient hot electron transfer and broadband solar-driven hydrogen generation.

Transgenic modification of silkworms has the potential to engineer new silks with a wider range of properties. Here, the authors engineered the expression of the outer layer sericin SER3 in the inner fibroin layer generating a new silk with higher production efficiency and resistance to alkaline conditions.

The need to use blue or high-energy near-UV light limit the synthetic applications of the combination of photocatalysis and transition-metal catalysis. Here, the authors report a method for red-light-driven nickel catalyzed cross-coupling reactions of aryl halides with 11 different types of nucleophiles using a polymeric carbon nitride as photocatalyst.

A mechanical exfoliation method for producing freestanding metal oxide ultrathin flakes is reported. The flakes can be transferred and integrated with 2D materials, providing a platform to investigate the fundamental properties of ultrathin metal oxides.

Functional devices based on sliding ferroelectrics remain elusive. This work demonstrates the rewritable, non-volatile memory devices at room-temperature with two-dimensional sliding ferroelectric rhombohedral-stacked bilayer MoS₂. The device shows overall good performance and can be made flexible.

Varying growth temperatures enables the tuning of the degree of disorder, which is fully described by the absence/presence of medium-range order and temperature-dependent densities of nanocrystallites, and electrical conductivity in amorphous monolayer carbon films.

Single-walled carbon nanotubes of a single chirality can be produced with an abundance of more than 92 per cent when using tungsten-based bimetallic alloy nanocrystals as catalysts.

2D MoS₂ is being intensively investigated as a promising candidate to extend the downscaling of electronic devices. Here, the authors report a buffer-layer-control method for the growth of wafer-scale single-crystalline MoS₂ monolayers on industry-compatible sapphire substrates with competitive optical and electronic properties.

This study reports a fully integrated 128 × 8 optoelectronic memristor array with Si complementary metal–oxide–semiconductor circuits, featuring configurable multi-mode functionality. It demonstrates diversified in-sensor computing tasks and consumes 20 times less energy than GPUs.

 Centimetre-sized single-crystal rhombohedral boron nitride layers are achieved through bevel-edge epitaxy, and the resulting material exhibits robust, homogeneous and switchable ferroelectricity with a high Curie temperature.

An “all-in-one” high-entropy semiconductor photocatalyst enables the photocatalytic production of H₂O₂ from H₂O and O₂ under visible light without any external cocatalysts or sacrificial agents

The application of 2D MoS₂ flexible integrated circuits (ICs) is currently limited by the material quality over large areas and the device fabrication technology. Here the authors report a gate-first fabrication technique to realize wafer-scale monolayer MoS₂ ICs on rigid and flexible substrates with high performance and low power consumption.

Weaving purely organic molecular threads into two-dimensional patterns remains a formidable challenge. Now, driven by the formation of dative B–N bonds, a purely organic, two-dimensional and flawless woven polymer network has been prepared. In addition, free-standing monolayers of woven polymer nanosheets have been obtained through mechanical exfoliation.

Multiwalled boron nitride nanotubes, featuring coherently stacked structures with monochirality, homo-handedness and unipolarity among the component tubes, show a large nonlinear chiroptical response.

The epitaxial growth of large single-crystal hexagonal boron nitride monolayers on low-symmetry copper foils is demonstrated.

Despite various known topological polar structures, the dynamic property of isolated ones is still poorly understood. Here, the authors show the controlled nucleation and ability to move of isolated three-fold vertices under an applied electric field.

While the role of PbTiO₃ in PbTiO₃/SrTiO₃ superlattices has been widely studied, little attention is paid to possible polar topologies in SrTiO₃. Here, the authors create atomic-scale vortex–antivortex pairs in the superlattices, expanding the understanding of topological structures.

The Alx3 transcription factor, expressed in prenatal tooth development, is shown to revitalize adult progenitor cells in decellularized scaffolds, leading to enhanced parenchymal dental pulp and vascularized stroma regeneration in vivo.

Controlling topological polar vortices promises to open up new applications for ferroelectric materials. Here, the authors proposed a method to mechanically manipulate polar vortices and monitored the transition between vortex and ferroelectric phase by in-situ scanning transmission electron microscopy.

H₂O₂ electrosynthesis has garnered great attention as a green alternative to the anthraquinone process. Here the authors propose a cost-effective cathode to greatly improve the O₂ diffusion coefficient, resulting in a high H₂O₂ production without the need for aeration.

Large strain gradient is crucial for flexoelectricity. Here, the authors reveal the generality and tunability of large strain gradients at grain boundaries in oxides, explaining the possible effects on the electrical activities of ceramics.

The first samples of pristine graphene were obtained by 'peeling off' and epitaxial growth, but chemical approaches are more suited to large-scale production. Exfoliation, reintercalation and expansion of graphite can produce high-quality single-layer graphene sheets suspended in organic solvents, and these sheets can be made into large transparent films by Langmuir–Blodgett assembly.

Large-area single-crystal high-index copper and nickel foils with several types of facet are fabricated using mild pre-oxidation of the metal foil surface followed by annealing in a reducing atmosphere.