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Erratum: Epitranscriptome sequencing technologies: decoding RNA modifications

Xiaoyu Li
Xushen Xiong
Chengqi Yi
Amendments and Corrections28 Feb 2017
Nature Methods

Volume: 14, P: 323
Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder

Immune dysfunction is implicated in bipolar disorder, but mechanisms are unclear. Here, the authors map epigenomic changes in peripheral blood from patients with bipolar disorder and link them to genetic risk and regulatory networks, revealing new disease mechanisms, patient subtypes, and potential therapeutic targets.

Lei Hou
Yue Li
Manolis Kellis
ResearchOpen Access15 May 2026
Nature Communications

P: 1-23
Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death

Tau aggregates disrupt heterochromatin by sequestering H3K9me3, reactivating transposable elements. This generates Z-RNAs, activating ZBP1 to drive neuronal death. ZBP1 haploinsufficiency reverses cognitive decline in aged tau mice, offering a therapeutic target for tauopathies.

Wei Liu
Song-Ang Wu
Wei Mo
Research20 May 2026
Nature Neuroscience

P: 1-14
Deep learning prediction of ribosome profiling with Translatomer reveals translational regulation and interprets disease variants

A transformer-based approach called Translatomer is presented, which models cell-type-specific translation from messenger RNA expression and gene sequence, bridging the gap between messenger RNA and protein levels as well as providing a mechanistic insight into the genetic regulation of translation.

Jialin He
Lei Xiong
Xushen Xiong
Research23 Oct 2024
Nature Machine Intelligence

Volume: 6, P: 1314-1329
Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease

Analysis of H3K27ac genome-wide maps across 387 brain, heart, muscle and lung samples, along with eQTL and genome-wide association studies (GWAS) data integration, identifies tissue-specific genetically influenced active regulatory regions and target genes that potentially mediate disease etiology.

Lei Hou
Xushen Xiong
Manolis Kellis
ResearchOpen Access28 Sept 2023
Nature Genetics

Volume: 55, P: 1665-1676
Genetic drivers of m⁶A methylation in human brain, lung, heart and muscle

Analysis of 129 N⁶-methyladenosine (m⁶A) profiles across 4 tissues (brain, lung, muscle and heart) identifies 8,843 tissue-specific and 469 tissue-shared m⁶A quantitative trait loci (QTLs). Of these, 184 m⁶A QTLs colocalize with GWAS signals.

Xushen Xiong
Lei Hou
Manolis Kellis
Research01 Jul 2021
Nature Genetics

Volume: 53, P: 1156-1165
N¹-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m¹A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m¹A inhibition decreases tumourigenesis in preclinical models of hepatocellular carcinoma.

Yanying Wang
Jing Wang
Zusen Fan
ResearchOpen Access02 Nov 2021
Nature Communications

Volume: 12, P: 1-19
Transcriptome-wide mapping reveals reversible and dynamic N¹-methyladenosine methylome

A method called m¹A-ID-seq, which involves antibody enrichment and reverse transcriptase–based sequencing of N¹-methyladenosine (m¹A) RNA modifications, reveals that m¹A is a reversible mRNA modification that is abundant in the 5′ UTRs of human genes.

Xiaoyu Li
Xushen Xiong
Chengqi Yi
Research10 Feb 2016
Nature Chemical Biology

Volume: 12, P: 311-316
Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cells

Using single-cell and spatial molecular profiling of infarcted mouse and human hearts, Li, Ni, Wang and colleagues identify a subset of cardiac fibroblasts expressing CD248 that plays a critical role in fibroblast–T cell interaction, and show that disrupting this interaction with monoclonal antibodies or anti-CD248 chimeric antigen receptor T cells results in reduced cardiac fibrosis and improved function.

Guohua Li
Cheng Ni
Xinyang Hu
Research27 Mar 2025
Nature Cardiovascular Research

Volume: 4, P: 380-396
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly

Proper splicing requires efficient spliceosome assembly. Here the authors reveal that zinc finger protein 207 interacts with the U1 small nuclear ribonucleoprotein to accelerate spliceosome assembly by increasing the local concentration of splicing regulators through phase separation.

Yuenan Zhou
Chong Tong
Yafei Yin
Research06 Mar 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1038-1049
Epitranscriptome sequencing technologies: decoding RNA modifications

This Review describes the latest methods for profiling common epitranscriptomic marks, their scale, resolution and ability to quantify. It also discusses remaining challenges.

Xiaoyu Li
Xushen Xiong
Chengqi Yi
Reviews29 Dec 2016
Nature Methods

Volume: 14, P: 23-31

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