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This study identifies viral poly(T) DNA as a key determinant of AIM2 inflammasome activation, revealing how viral genome variation shapes inflammatory responses and host survival during infection.

Colloidal particle suspensions often exhibit an undesirable size distribution, which adversely affects their property profile. Here, the authors demonstrate size-selective purification of colloids by fractional crystallization, enabling separation at a size difference of less than 10%.

The estimated minimum particle size for cryo-EM structural analysis is 38 kDa. Here, authors show that high-resolution structures of protein-ligand complexes as small as 32- 41 kDa can be determined using this technique without structural fiducials.

Neuromorphic computing hardware normally makes an unideal trade-off between energy efficiency, scalability and reliability. Kim et al. report a ferroelectric heterostructure based memristor with near-zero nonlinearity, endurance beyond 10E7 cycles, rectifying ratio exceeding 10E6 and sub-pA off-current.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Haptic interfaces for full-body scale requires a balance of high-resolution tactile simulation and breathability. Here, the authors present a breathable, full-body electrical stimulation suit for prolonged use in extended reality applications.

Homologous recombination (HR) safeguards genome stability, but the regulation of HR proteins remains unclear. Here, the authors show that the compound UNI418 inhibits lipid kinases PIKfyve and PIP5K1C, reducing IP6 levels and triggering Cul4A–WDR5 dependent degradation of HR proteins, thereby suppressing HR and overcoming PARP inhibitor resistance.

Conventional wireless sensors typically rely on dielectric capacitors with inherently low capacitance, requiring operation at MHz frequencies. Here, the authors develop a wireless low-frequency electrochemical sensing platform that couples ionic dynamics with low-frequency inductor-capacitor resonant circuits.

This study found that obesity increases the stress protein REDD1, which drives vascular ageing and high blood pressure. REDD1 activates an atypical NF-κB signaling pathway and microRNAs that switch off genes protecting blood vessels. Blocking this pathway improves vascular and kidney function in obese mice, highlighting a potential therapeutic target.

Probabilistic computing is increasingly valuable for exploring optimal solutions in data science as data volumes continue to grow, highlighting probabilistic computing as a practical solution. Park et al. report a CMOS-compatible array with transistors that serve as both p-bit and synapse, enabling single-chip probabilistic computing.

Reactive lithium metal readily corrodes, but its behavior is mainly understood qualitatively with limited mechanistic insight. Here, authors present a quantitative framework linking lithium corrosion to interphase growth and morphology evolution, guiding a bi-layered passivation design strategy.

The authors developed a recombinant protein mimicking platelet function by binding to injury sites and forming fibrin networks via thrombin capture. It safely reduced bleeding in trauma and chemotherapy mouse models.

Logic-in-memory is a promising approach to break the von Neumann bottleneck in conventional skin electronics. Park et al. report a wafer-scale stretchable photoelectric memory transistor array that integrates non-volatile memory with in-situ logic reconfiguration, enabling stable operation even under strain.

Ballistic transport is achieved in nanodevices based on atomically flat, grain-boundary-free single-crystalline Cu(111) thin films. Negative bend resistance below 85 K confirms it, establishing a scalable platform for exploring quantum nature of Cu.

This work demonstrates a biologically inspired ultrathin camera that achieves high-resolution, 140° wide field-of-view imaging through angular sampling on a single planar sensor, thereby advancing compact wide field-of-view imaging systems.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Here the authors report preclinical evidence showing that PG-102, a potency-optimized bispecific Fc fusion protein targeting GLP-1 and GLP-2 receptors, results sustained glycemic control with preserved body weight in mouse models of advanced diabetes. Furthermore, a phase I randomized controlled clinical trial in healthy adults with overweight suggest PG-102 is well tolerated.

Osteoarthritis is a marked by cartilage loss and limited by the absence of effective disease modifying treatments. Here, the authors show that orphan nuclear receptor small heterodimer partner (SHP) protects cartilage by suppressing IKKβ dependent NF κB signaling, highlighting it as a potential therapeutic target.

High-resolution displays require precise patterning of quantum dots without compromising their performance. Here, the authors report on a process for manufacturing dense RGB pixel arrays with a resolution exceeding 4,000 pixels per inch and high fidelity for future displays.

Here the authors report real-world evidence through a retrospective analysis of a multinational cohort of 1.8 M older adults showing that GLP1RAs and SGLT2 inhibitors carry lower risk for hyperkalemia than sulfonylureas. However, SGLT2 inhibitors increased risk of ketoacidosis. Findings support safety-conscious prescribing for older adults, who are often underrepresented in clinical trials.

This study identifies an FDA-approved leukemia drug, Homoharringtonine, that can eliminate aged fat cells, improve metabolic health, reduce inflammation and extend lifespan in mice, revealing a potential approach to treat age- and obesity-related metabolic disease.

Rechargeable magnesium batteries offer low cost and safety, but are limited by moisture-sensitive Mg metal. Here, authors show that brief trimethyl phosphate treatment creates a sacrificial protective Mg electrode, enabling stable operation and cell fabrication under humid or ambient conditions.

Modulating synaptic connections remains challenging. Here, the authors show that SynTrogo (Synthetic Trogocytos) is a synthetic astrocyte-neuron interaction system, and reduces synaptic connectivity, which is associated with enhanced plasticity and improved memory.

Bio-interfaced applications are limited by the transfer of soft electronic devices onto high curvature and fragile surfaces. Here, the authors develop a stress-responsive transfer fluid that enables distortion-free, adhesion-switchable transfer for conformal integration and stable real-time bioelectronic sensing.

As soft electronic waste becomes an urgent concern, biodegradable yet high-performance devices are emerging as a promising solution. Here the authors fabricate durable and multifunctional soft robotic fingers in which both polymers and inorganic electronics are fully compostable.

The paper presents a piezoelectric resonator-based DC-DC converter with an embedded flying capacitor and multipath operation. Implemented with an integrated circuit, the design achieves 96.2% efficiency at greater than the optimal 9:1 voltage conversion ratio with enhanced current handling for data center applications.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Breeding crops with delayed senescence could plausibly increase grain yield. Here the authors show that variation at the rice SGR locus contributes to differences in senescence between indica and japonica subspecies and show that introgression can increase yield in an elite indica rice variety.

Stretchable liquid-metal electronics is limited by high surface tension, fluidity, and poor wettability. Here, Lee et. al. presents a universal cryogenic transfer method for liquid metal particles, enabling high-throughput fabrication of wafer-scale stretchable integrated electronics with robust electrical performance.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

This study develops and validates a prognostic staging framework for Alzheimer’s disease by integrating cognitive status with blood-based biomarkers, and neuroimaging data, to improve risk stratification across the disease continuum.

A series of in vitro and in vivo CRISPR activation screens combined with in situ Perturb-seq identify regulators of T cell-dependent cytotoxicity in melanoma.

Appel et al. found that deceptive networks reached over 37 million Facebook and 3 million Instagram users during the 2020 US elections, with the majority of this exposure driven by 3 networks and amplified by ordinary users resharing the content.

The detection of forsterite and enstatite emissions in EC 53 during accretion bursts marks one of the first pieces of direct evidence of in situ silicate crystallization in young stars.

Stromatolites within the Hapcheon impact crater suggest that asteroid impacts created hydrothermal oases fostering early life and habitability, according to geochemical, isotopic, and microbial analyses from the Hapcheon crater lake in Korea.