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Scientific Reports (22)
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Showing 1–50 of 63 results

Advanced filters: Author: Yakun Li Clear advanced filters

Experimental study on grouting diffusion mechanism of fractured rock

Chong Zhang
Donghao Li
Xiang Gao
ResearchOpen Access14 Jan 2026
Scientific Reports

P: 1-16
Structural mechanism of the agonist binding on human TRPC3 channel

TRPC3/6/7 are DAG-activated cation channels. The authors report structures of human TRPC3 in complex with DAG or synthetic activators 4n and GSK1702934A. These results lead to the identification of monoacylglycerols as endogenous activators of TRPC3/6/7 channels.

Yikun Chen
Jiahe Zang
Lei Chen
ResearchOpen Access22 Oct 2025
Nature Communications

Volume: 16, P: 1-11
Nanopore-based enzyme-linked immunosorbent assay for cancer biomarker detection

A nanopore-based enzyme-linked immunosorbent assay is developed for the single-molecule sensing of distinct current signatures from peptide probes generated on translocation through α-hemolysin after enzymatic cleavage, enabling the multiplexed detection of biomarkers in blood samples.

Yakun Yi
Peng Song
Hai-Chen Wu
Research14 May 2025
Nature Nanotechnology

Volume: 20, P: 1079-1086
Author Correction: Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice

Ting Li
Dingyi Lu
Xin Pan
Amendments and CorrectionsOpen Access17 Mar 2022
Nature Communications

Volume: 13, P: 1
A bispecific antibody–drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial

In the dose-expansion cohort of this phase 1b trial, the EGFR×HER3 bispecific antibody–drug conjugate BL-B01D1 given to patients with metastatic esophageal squamous cell carcinoma led to encouraging clinical response rates, which need to be confirmed in larger efficacy trials.

Chang Liu
Dan Liu
Zhihao Lu
ResearchOpen Access10 Jul 2025
Nature Medicine

Volume: 31, P: 3485-3491
Ambient hydrogenation of solid aromatics enabled by a high entropy alloy nanocatalyst

Traditional hydrogenation of aromatics requires high temperatures and pressures. Here, the authors present a PdPtRuCuNi high entropy alloy nanocatalyst that achieves 100% hydrogenation of solid aromatics at 25 °C without the need for solvents.

Zekun Jing
Yakun Guo
Maobing Shuai
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Peptide sequencing based on host–guest interaction-assisted nanopore sensing

A phenylalanine-containing peptide probe can be used for discriminating all 20 amino acids via current blockage during translocation through an α-hemolysin (αHL) nanopore. The paper provides proof-of-concept peptide sequencing demonstrations.

Yun Zhang
Yakun Yi
Hai-Chen Wu
Research13 Nov 2023
Nature Methods

Volume: 21, P: 102-109
Integrated copper-halide activated scintillator fiber array for remote high-resolution X-ray imaging

Zhang et al. report the incorporation of copper halide perovskite nanocrystals into glass fibre arrays for high-resolution remote scintillation over 5 m without crosstalk. Real-time and 3D X-ray imaging are demonstrated employing 1600 densely packed fibres with a single pixel diameter of about 10.4 µm.

Hao Zhang
Xiongjian Huang
Guoping Dong
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-9
Giant electrocaloric effect in high-polar-entropy perovskite oxides

Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

Feihong Du
Tiannan Yang
Xiaoshi Qian
Research09 Apr 2025
Nature

Volume: 640, P: 924-930
Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice

Here the authors show that the Koolen-de Vries syndrome associated gene KANSL1 modulates autophagosome-lysosome fusion via transcriptional regulation of autophagosomal gene Syntaxin17, and that 13-cis retinoic acid can reverses mitophagic defects and neurobehavioural abnormalities of mice lacking Kansl1.

Ting Li
Dingyi Lu
Xin Pan
ResearchOpen Access17 Feb 2022
Nature Communications

Volume: 13, P: 1-16
An integrated framework for evaluating landscape performance in tourism-oriented rural areas

Yingnan Li
Guangxi Shen
Lu Ding
ResearchOpen Access08 Dec 2025
Scientific Reports

Volume: 15, P: 1-18
GABAergic neurons in central amygdala contribute to orchestrating anxiety-like behaviors and breathing patterns

Anxiety involves abnormal respiratory responses to emotional stimuli. Here, the authors show that CeA^GABA neurons, acting as a central hub, are instrumental in orchestrating anxiety-like behaviors and breathing patterns through the CeA-PVT and CeA-LPBN-preBötC circuits, correspondingly.

Xiaoyi Wang
Shangyu Bi
Sheng Wang
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-23
High performance tandem organic solar cells via a strongly infrared-absorbing narrow bandgap acceptor

Development of tandem organic solar cells has been limited by the choice of near-infrared absorbing materials for the rear cell. Here, the authors report a simple strategy to extend the conjugation length of acceptor Y6 and broaden its absorption range to near-infrared region. A tandem organic solar cell with efficiency of 16.4% was achieved.

Zhenrong Jia
Shucheng Qin
Yongfang Li
ResearchOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1-10
Oncogenic activation of EVC/EVC2 defines a therapeutically targetable subset of acute myeloid leukemia

Pinpin Sui
Ying Li
Feng-Chun Yang
Research17 Nov 2025
Leukemia

Volume: 40, P: 166-177
Improving the SO₂ tolerance of CO₂ reduction electrocatalysts using a polymer/catalyst/ionomer heterojunction design

While the high concentration of CO₂ in flue gas makes it an attractive feedstock for electrocatalytic production of useful molecules, SO₂ contaminants can poison catalysts. Here the authors report a polymer/catalyst/ionomer heterojunction design with hydrophobic and hydrophilic domains that improves the SO₂ tolerance of a Cu catalyst.

Panagiotis Papangelakis
Rui Kai Miao
David Sinton
Research04 Jul 2024
Nature Energy

Volume: 9, P: 1011-1020
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results

In an interim analysis of a phase 1 trial, CAR T cells specific for Claudin18.2, a tight junction protein isoform highly expressed on gastrointestinal tract tumors, were well-tolerated and exhibited promising clinical activity in patients with gastrointestinal cancers.

Changsong Qi
Jifang Gong
Lin Shen
ResearchOpen Access09 May 2022
Nature Medicine

Volume: 28, P: 1189-1198
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results

In the largest study so far of CAR T cells in patients with solid tumors, autologous CLDN18.2-targeting CAR T cell therapy was well tolerated in patients with advanced CLDN18.2-positive gastrointestinal cancers, with an overall response rate of 42.2% and a disease control rate of 91.1%.

Changsong Qi
Chang Liu
Lin Shen
Research03 Jun 2024
Nature Medicine

Volume: 30, P: 2224-2234
SHP1 and its downstream p38/SP1/PI3K/YAP/Notch-1 signaling in trophoblast cells suppressed the progression of Preeclampsia via inhibiting proliferation of SMCs

Yan An
Chenyuan Cao
Yakun Zhao
ResearchOpen Access09 May 2025
Scientific Reports

Volume: 15, P: 1-11
A study on different variables on the distribution law of oil and gas diffusion concentration of internal floating roof tanks

JiChao Li
Xingjian Li
Yan Liu
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-34
The interaction effect of regulatory focus and negative feedback on proactive behavior: the mediating role of perceived insider status

Tengfei Guo
Yakun Ni
Shenyang Hai
ResearchOpen Access30 Dec 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-11
Artificial two-dimensional polar metal at room temperature

Materials that combine metallic behaviour with stable electric polarization are scarce despite being proposed in the 1960s. Here the authors engineer a perovskite heterostructure where 2D polar metallic behavior coexists with built-in electric polarization from the displacement of B-site titanium cations.

Yanwei Cao
Zhen Wang
J. Chakhalian
ResearchOpen Access18 Apr 2018
Nature Communications

Volume: 9, P: 1-9
Fabrication of in-situ grown graphene reinforced Cu matrix composites

Yakun Chen
Xiang Zhang
Naiqin Zhao
ResearchOpen Access14 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Subterahertz collective dynamics of polar vortices

A dynamical study shows that vortices of electrical polarization have higher frequencies and smaller size than their magnetic counterparts, properties that are promising for electric-field-driven data processing.

Qian Li
Vladimir A. Stoica
Haidan Wen
Research14 Apr 2021
Nature

Volume: 592, P: 376-380
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice

Rumeng Tan
Hongzhe Tian
Zhishui Chen
ResearchOpen Access02 Oct 2018
Scientific Reports

Volume: 8, P: 1-9
Perceived overqualification and innovative work behavior: a moderated mediation model

Tengfei Guo
Chen Lan
Yanzhen Xu
ResearchOpen Access11 Nov 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-9
Predicting gastric cancer response to anti-HER2 therapy or anti-HER2 combined immunotherapy based on multi-modal data

Zifan Chen
Yang Chen
Lin Shen
ResearchOpen Access26 Aug 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-12
FPR3 sustains the immunosuppression of tumor-associated macrophages and accelerates the progression of gastric adenocarcinoma

Minqiong Sun
Zhenya Tan
Hong Zheng
Research23 Sept 2025
Oncogene

Volume: 44, P: 4309-4323
A high-quality chromosome-level genome assembly and annotation of the giant freshwater prawn (Macrobrachium rosenbergii)

Lingyun Yu
Haiyang Liu
Yakun Wang
ResearchOpen Access10 Jul 2025
Scientific Data

Volume: 12, P: 1-9
PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial

Yakun Wang
Jialin Lu
Xiaotian Zhang
ResearchOpen Access14 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-11
A core driver gene set identified based on geMER reveals its potential driver mechanism in pan-cancer

Jing Gan
Yuncong Wang
Hui Zhi
ResearchOpen Access09 Aug 2025
npj Precision Oncology

Volume: 9, P: 1-19
Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study

Dan Liu
Jifang Gong
Lin Shen
ResearchOpen Access19 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-10
TSPO deficiency promotes the progression of malignant peripheral sheath tumors by regulating the G2/M phase of the cell cycle via CDK1

Xingnan Zhang
Chenhao Hu
Song Liu
ResearchOpen Access31 Oct 2024
Scientific Reports

Volume: 14, P: 1-16
Nuclear soluble cGAS senses double-stranded DNA virus infection

Cellular infection with HSV-1 releases cGAS from the chromatin into the nuclear soluble fraction, leading to viral sensing and a type I interferon host response.

Yakun Wu
Kun Song
Shitao Li
ResearchOpen Access10 May 2022
Communications Biology

Volume: 5, P: 1-13
Study on material point failure probability of complex jointed rock masses based on peridynamics

Yigong Zhao
Xiaoyan Zhang
Yakun Guo
ResearchOpen Access25 Mar 2025
Scientific Reports

Volume: 15, P: 1-22
Comparative analysis of the mitochondrial genomes of the soft-shelled turtles Palea steindachneri and Pelodiscus axenaria and phylogenetic implications for Trionychia

Chen Chen
Liqin Ji
Wei Li
ResearchOpen Access28 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
FIP200 restricts RNA virus infection by facilitating RIG-I activation

Lingyan Wang et al. report that the autophagy-associated protein FIP200 interacts with the RNA sensor RIG-I to trigger activation of the type I interferon pathway.

Lingyan Wang
Kun Song
Shitao Li
ResearchOpen Access29 Jul 2021
Communications Biology

Volume: 4, P: 1-15
Single-cell RNA sequencing reveals the epithelial cell, fibroblast, and key gene alterations in chronic rhinosinusitis with nasal polyps

Yakun Wang
Zufei Li
Jun Lu
ResearchOpen Access27 Jan 2024
Scientific Reports

Volume: 14, P: 1-14
Molecular evidence for the involvement of a polygalacturonase-inhibiting protein, GhPGIP1, in enhanced resistance to Verticillium and Fusarium wilts in cotton

Nana Liu
Xueyan Zhang
Yuxia Hou
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-18
Identification of functional cooperative mutations of SETD2 in human acute leukemia

Tao Cheng, Qian-fei Wang, Gang Huang and colleagues identify recurrent somatic loss-of-function mutations in SETD2 in individuals with acute leukemia. SETD2 encodes a histone H3K36 methyltransferase, and loss of SETD2 function causes global loss of H3K36 trimethylation and promotes leukemia stem cell self renewal.

Xiaofan Zhu
Fuhong He
Qian-fei Wang
Research09 Feb 2014
Nature Genetics

Volume: 46, P: 287-293
Hereditary spherocytosis before and after splenectomy and risk of hospitalization for infection

Yakun Liu
Shaobin Jin
Yajun Chen
Research01 Aug 2022
Pediatric Research

Volume: 93, P: 1336-1341
Serum β2-microglobulin level is associated with the survival of HIV-associated diffuse large B-cell lymphoma: a retrospective study from China

Xinyi Tang
Tingting Jiang
Zailin Yang
ResearchOpen Access07 May 2025
Scientific Reports

Volume: 15, P: 1-11
Screening chronic kidney disease through deep learning utilizing ultra-wide-field fundus images

Xinyu Zhao
Xingwang Gu
Youxin Chen
ResearchOpen Access07 Oct 2024
npj Digital Medicine

Volume: 7, P: 1-11
Life cycle environmental impact assessment of natural gas distributed energy system

Yakun Wang
Ting Ni
Jiuping Xu
ResearchOpen Access08 Feb 2024
Scientific Reports

Volume: 14, P: 1-18
Deletion of FGF9 in GABAergic neurons causes epilepsy

Moran Guo
Can Cui
Chunyan Li
ResearchOpen Access19 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-13
CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition

Zhenya Tan
Ke Pan
Hong Zheng
Research20 Aug 2024
Cell Death & Differentiation

Volume: 31, P: 1302-1317
Does the Dirac Cone Exist in Silicene on Metal Substrates?

Ruge Quhe
Yakun Yuan
Jing Lu
ResearchOpen Access27 Jun 2014
Scientific Reports

Volume: 4, P: 1-8
Dissecting the genetic architecture of Fusarium verticillioides seed rot resistance in maize by combining QTL mapping and genome-wide association analysis

Ming Ju
Zijian Zhou
Jianyu Wu
ResearchOpen Access19 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections

The authors observed an increase of talin-vinculin spatial proximities in the livers of spotted fever Rickettsia australis or Ebola virus-infected mice when compared to mock mice. Furthermore, using EPAC1 knockout mice, they found that deletion of EPAC1 suppresses the formation of spatial proximal complex of talin-vinculin in rickettsial infections.

Yakun Liu
Jie Xiao
Bin Gong
Research01 Apr 2020
Laboratory Investigation

Volume: 100, P: 1030-1041
Control of breathing by orexinergic signaling in the nucleus tractus solitarii

Yakun Wang
Tianjiao Deng
Sheng Wang
ResearchOpen Access29 Mar 2024
Scientific Reports

Volume: 14, P: 1-12
The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model

Weisong Duan
Moran Guo
Chunyan Li
Research09 Dec 2019
Gene Therapy

Volume: 27, P: 157-169

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