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Current anion exchange membrane water electrolysers are hindered by poor performance in pure water. Here, the authors report a strategy that creates built-in alkaline microenvironments, enabling high performance and long-term stability using only pure water.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Magnetic kagome metals are an ideal platform for investigating the interplay between spin and charge degrees of freedom. Here, the authors provide evidence of a charge-density wave intrinsically coupled to spin degrees of freedom in GdTi₃Bi₄, consistent with a spin–intertwined charge density wave.

Relaxor ferroelectricity is achieved in two-dimensional CuInP₂(S_1−xSe_x)₆ crystal via controlling the monoclinic and trigonal coexist phase, enabling memristors with more analog states and lower operating voltages.

Thermal cloaks featuring nanoscale accuracy are limited by fabrication scalability and weak durability. Here, the authors report a hierarchical design achieved through femtosecond laser writing, which provides superior cloaking performance while maintaining robustness against harsh erosion and contaminant exposure.

The catalyst-free production of H₂O₂ at hydrophobe-water micro-interfaces provides a sustainable synthesis route, yet scalability remains challenging. Here the authors demonstrate that hydrophobic macroporous resins can serve as robust, metal-free platform to construct scalable and robust hydrophobe-water interfaces for continuous H₂O₂ generation.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Prostate cancer heterogeneity limits the efficacy of current therapeutic approaches. Here, the authors develop two methods, snFLARE-seq and mxFRIZNGRND, using formalin-fixed paraffin embedded samples for analysing the transcriptomic and metabolomic landscape of different anatomical origins.

Rhombohedral-stacked structures formed by 2D semiconductors are characterized by emerging physical properties, but their bottom-up growth remains challenging. Here, the authors report a chemical vapour deposition method to grow cm-scale rhombohedral-stacked WS₂/MoS₂ crystals with ferroelectric properties.

While interest in copper nanoclusters has grown due to the high abundance, low cost, and unique properties of copper, modular synthesis remains underdeveloped. Here, the authors report a strategy for constructing structurally well-defined copper nanoclusters through the synergistic combination of photochemical activation and nanoscale ligand-exchange.

A single-crystalline aluminum nitride seed layer improves crystal alignment in scandium-doped aluminum nitride films, and subsequent removal eliminates polarity mismatch, enabling high-performance film bulk acoustic resonators and wideband filters.

Authors show that Ag₂Te achieves room-temperature plasticity via stress-driven silver ion hopping, which enables crystal rotation, combining high flexibility with efficient thermoelectric performance for wearable electronics.

The authors report an omnidirectional, strain-invariant MXene-based electronic system enabled by microgrid stiffness engineering, maintaining less than 5% performance variation under 40% tensile strain for battery-free physiological and blood pressure monitoring.

Leveraging electron-phonon coupling allows for modulating self-trapped exciton formation for broadband white-light emission. Using transient spectroscopy and DFT calculations, Zhang et al. correlate the structural distortion with self-trapped exciton formation in 2D halide perovskites.

Here they identify a functional Thyroid Hormone protein precursor in ascidian, named ScTG-like, and detected the follicle-like structure for TH synthesis. These findings suggest TG-like proteins are conserved in bilaterians, providing insight into the evolution of TH synthesis.

Using ARPES, this work identifies dice-lattice flat bands in the electride material YCl. The authors show that anionic electrons act as lattice sites to create this rare electronic structure.

The use of benzene ring contraction in chemical synthesis is challenging due to the need to disrupt aromaticity and generate highly strained intermediates. Now, a photothermal ring contraction reaction for the synthesis of multisubstituted fused pyridines is reported, from arylhydrazines and carbonyl compounds, via benzene ring contraction.

Hierarchical immobilization of multicomponent biomacromolecules is promising for constructing advanced biopharmaceuticals, but remains challenging. Here, the authors report a multicomponent synergistic approach integrating in-situ and dynamic exchange methods to construct hierarchical biopharmaceutical formulations.

Grain chalkiness is an undesirable trait that severely compromises rice quality. Here, the authors report the cloning of an E3 ubiquitin ligase encoding gene Chalk9 and reveal its crucial role in regulating grain chalkiness through mediating the ubiquitination-dependent degradation of OsEBP89.

Chemotherapy-induced intestinal toxicity limits treatment efficacy. Here, the authors show that myeloid-derived L-kynurenine exacerbates this damage by depleting Lactobacillus johnsonii, which activates the TNFα/JNK pathway to drive epithelial apoptosis.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

The integration of high-κ dielectrics with low equivalent oxide thickness (EOT) is crucial for the development of 2D transistors. Here, the authors report the low-temperature fabrication of wafer-scale HfO₂ dielectric films with sub-5-Å EOT and their application for the realization of high-performance 2D MoS₂ transistors and circuits.

Intrauterine adhesions (IUA) are a leading cause of female infertility. Here, authors engineer a Tβ4-releasing ECM hydrogel that mimics decidualization to promote endometrial regeneration as a therapeutic strategy for treatment of IUA.

Uncontrollable hemorrhage is a leading cause of preventable death. Here, Huang et al. develop a rapid, self-expanding, coagulation-promoting hemostatic powder for non-compressible hemorrhage management.

The spatial organisation of the tumour microenvironment (TME) can affect immune responses that control tumour growth. Here, the authors use single-cell transcriptomics and spatial transcriptomics to identify a lymphocyte aggregated region (LAR) in gastric cancer and compare its cellular and molecular composition with the neighbouring TME.

SARS-CoV-2 variants often exhibit immune evasion, necessitating antiviral strategies beyond vaccination. This study presents a papain-like protease (PLpro) inhibitor called YL1004, which exhibits potent, broad-spectrum antiviral activity against wild-type, Delta, and Omicron variants in vitro and in vivo.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

Metal-cation-free CO₂ electroreduction in strong acid minimizes reactant loss and salt precipitation yet struggles with CO₂ activation and hydrogen evolution competition. Here, the authors report bioinspired sharp gold triangles with a proton-blocking layer that polarize CO₂ and suppress hydrogen evolution.

Direct RNA sequencing suffers from chimera artifact contamination. Here, the authors develop DeepChopper, a genomic language model that detects artifacts with high accuracy, enabling more reliable transcriptome analysis.

Zhang et al. report a foundry-compatible γ-ray treatment to induce chemical bond changes of organic contaminants in carbon nanotube transistors, mitigating the imperfections at the carbon nanotube/dielectric interface, reducing the off-state current density to 112.2 pA μm-1, and achieving radiation tolerance up to 100 Mrad(Si).

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Grain protein content determines rice nutrition quality. Here, the authors show that a single nucleotide polymorphism in the promoter region of OsGluA2, encoding a glutelin type-A2 precursor, is responsible for glutelin content difference between the indica and japonica rice subspecies.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Mechanisms of siphophage infection in Gram-positive bacteria remain poorly understood. Here, the authors report the high-resolution structure of phage NF5 and visualize its cell wall adsorption and genome delivery process.

Mechanisms confer to the enhanced cold tolerance in japonica rice have not been fully elucidated. Here, the authors report a homeodomain-leucine zipper (HD-Zip) I transcription factor encode gene CTB5 is responsible for japonica rice cold tolerance by interacting with genes in gibberellin and abscisic acid pathways.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

This study presents MAOSS, a multimodal AI model that repurposes non-contrast CT scans and leverages clinical features to detect and stage liver steatosis and fibrosis. Here the authors show MAOSS accurately stratifies cirrhosis progression risk when embedded into the standard clinical workflow, enabling scalable, opportunistic screening for early intervention of steatotic liver disease.

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunotherapies.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

Xu et al. report that inhibition of the F-box protein FBXL2 enhances HER2 expression, rendering HER2-negative breast cancer sensitive to the anti-HER2–drug conjugate trastuzumab deruxtecan.

A cellular neural network that incorporates transistors and multilevel non-volatile memristor synapses can be used for efficient image and video processing.

A platinum(II) azido complex (complex 1) that releases platinonitrene upon X-ray exposure induces DNA damage and enhances immune checkpoint blockade outcomes via the abscopal effect.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Zhang et al. examine associations between wildfire-specific PM_2.5 and emergency department visits for mental disorders in children across 845 communities in Australia, Brazil and Canada over a 15-year period.

A non-coplanar axially chiral molecular contact favours the crystalline growth of perovskite film and improves interfacial stability in perovskite solar cells. Small-area devices yield a certified power conversion efficiency of 26.44% and maintain 98% of it after 2,000 hours of operation.