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Intra-cell line heterogeneity remains to be characterized. Here, the use of single multi-omics on a large panel of human cell lines identifies copy number variation, epigenetic variation and extrachromosomal DNA distribution as the main contributors to intra-cell line heterogeneity.

This study provides a de novo resequencing of 802 Camellia accessions and a genome-wide variation map. Genome-wide association study (GWAS) and metabolite GWAS identify genes responsible for crucial agronomic and flavor traits.

Middle-aged obesity, marked by excessive fat accumulation, is closely linked to DNA damage. Here, the authors show that the DNA repair enzyme Eepd1, primarily expressed in adipose tissue, in its myristoylated form, promotes lipolysis and thermogenesis by activating PKA to combat obesity.

Single-nucleus transcriptomes uncover cell type-specific gene reprogramming in response to nod factors in Medicago, including a defence response at 30 min, which largely returned to normal at 6 h. The results reveal that MtFER interacts with LYK3 and regulates rhizobial symbiosis.

Genomic and phenomic screens of 827 wheat landraces from the A. E. Watkins collection provide insight into the wheat population genetic background, unlocking many agronomic traits and revealing haplotypes that could potentially be used to improve modern wheat cultivars.

Solid-phase synthesis strategy is promising for fabricating desired complex metal nanoparticles on supports. Here, the authors synthesize CoFe@FeOx core-shell nanoparticles as the separator coatings via precise solid-phase method which effectively regulates polysulfides for lithium/ sodium-sulfur batteries.

Broadband terahertz (THz) pulses are generated from a laser filament with a near-infrared laser at the fundamental frequency and its second harmonic. The azimuthal angle and ellipticity of the THz pulses are arbitrarily controlled by the two lasers.

The authors used a long-read nanopore method to study chromatin accessibility and DNA methylation of the highly repetitive centromeres, telomeres, and ribosomal DNA arrays in both wildtype and DNA methylation mutants of Arabidopsis.

DNA is a promising medium for data storage but requires efficient sequencing methods for real-time data retrieval. Here, authors introduce Composite Hedges Nanopores (CHN), a nanopore-based codec scheme that improves sequencing efficiency and data accuracy, supporting real-time data retrieval.

The phenomenon of Enteromorpha prolifera (EP) flooding caused by marine eutrophication has resulted in serious environmental impact. Here, the authors demonstrate an application of Fenton’s reagent in the rapid recovery and utilization of EP.

Shi and colleagues present a spatial microfluidic holographic integrated platform for label-free, high-dimensional analysis of cancer heterogeneity, achieving very high accuracy in classifying cancer types, breast cancer subtypes, and blood cells.

The conserved BAR domain protein FAM92A1 is known to induce membrane curvature. Here, the authors report the crystal structure of its BAR domain and perform an extensive characterization of the brain and behavior of FAM92A1 knockout mice.

Protein C receptor (PROCR) has been proposed as a cancer stem cell marker in different types of cancer. Here the authors report that PROCR upregulation in cancer cells is associated with resistance to radiotherapy and reduced anti-tumour immunity.

Environmental and dietary factors are known to play a role in the development of coronary heart disease. Here the authors apply a genomic-inspired methodology to Nurses’ Health Study data to explore comprehensively and agnostically the association of 257 nutrients and 117 foods with coronary heart disease risk.

Drug exposure during pregnancy lacks sufficient fetal safety information world-widely. Here, the authors report the establishment a multi-center birth cohort to explore the correlation of maternal drug exposure during pregnancy with pregnancy outcomes.

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Ytterbium oxide buffer layer for use in perovskite solar cells yields a certified power conversion efficiency of more than 25%, which enhances stability across a wide variety of perovskite compositions.

Jing et al. report a cost-effective chemical cross-linking method for synthesizing ultraflexible polymer-based phase change composites with 3D crosslinked networks and further demonstrate portable applications for wearable thermal management.

The interfaces in perovskite solar cells are critical to the device performance. Li et al. tune the bond strength of the interfacial molecule with the perovskite and the electron transport layer, increasing the power conversion efficiency of the cells.

The bacterial pathogen Ralstonia solanacearum secretes endonuclease RuvC, which degrades mature biofilm by targeting the lattice formed by cruciform extracellular DNA. This helps bacterial dispersal, pathogen spread in plant xylem and virulence.

The authors introduce the concepts of Robo-Matter and Robot-Matter duality, using magnetic spinner micro-robots. A wide range of functionalities and applications beyond the capability of both traditional inert and active materials is enabled.

The inefficient spin-flip process of multi-resonance emitters could compromise the device performance of light-emitting diodes. Here, the authors incorporate conformationally flexible donor to enhance the density of excited states, achieving 20-fold increase in reverse intersystem crossing rate.

A natural product containing an acylsulfenic acid functional group was discovered in a marine Streptomyces bacterium. Its biosynthesis is orchestrated by enzymes from both primary and secondary metabolism, including a flavin-dependent S-hydroxylase. The prevalence of enzymes catalysing the production of acylsulfenic acid in bacteria implies a potentially broad distribution of this functional group in specialized metabolites.

Dual targeting of BRAF and MAPK signaling in the BRAF v600E mutant colorectal cancer patients has shown limited efficacy in clinical studies. Here, the authors identify PLK1 inhibition as synthetic lethal with dual BRAF and EGFR inhibition due to loss of ferroptosis inhibition via a PLK1-CBX8-GPX4 signaling axis in preclinical models of colorectal cancer.

In a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metastatic KRAS^G12C-mutated nonsmall-cell lung cancer.

Mast cells have been shown to be involved with rheumatoid arthritis, but the mechanisms are not clear. Here using mouse models and making association with human patients, the authors show mast cells have an important function in the pathogenesis of rheumatoid arthritis, involving regulation of T cell responses and release of mast cell mediators.

In voltage-gated ion channels, transmembrane segments S3 and S4 are involved in voltage sensing and adopt a helix-turn-helix conformation, called the paddle motif, in crystal structures. Now extensive mutagenesis and electrophysiology analyses of the Shaker K⁺ channel demonstrate the physiological relevance of the paddle motif and dissect the roles of each segment in voltage sensing.

Solving component homogeneity and sulfur instability of metal sulfides is crucial for photocatalytic overall water splitting. Here, the authors develop a distortion evoked cation site oxygen doping to create electronegativity differences between adjacent atom and enhance photocatalytic activity

Marine ecosystems are dominated by microbial communities. Inspired by the photoelectric conversion feature of the marine ecosystems, the authors design a four-species microbial community to mimic primary producer, primary degrader, and ultimate consumers, and show its ability to convert light into electricity for over one month.

An analysis based on data from the Global Dietary Database shows mean animal-sourced food intakes among children and adolescents increased modestly from 1990 to two portions per day in 2018, but remain low in sub-Saharan Africa, India and Bangladesh.

Modeling analysis from the Global Dietary Database estimated that 70% of new global cases of type 2 diabetes are attributable to suboptimal intake of 11 dietary factors, with substantial differences in dietary risks across world regions and nations.

Power densities of existing microbial biophotovoltaics (BPV) are low and unendurable. Here, the authors develop a BPV based on d-lactate mediated microbial consortium, which can generate an average power density of 135 mW·m⁻² for over 40 days in a spatial-temporal separation setup with medium replenishment.

Controlling and preventing biological invasions requires transnational cooperation. This global study identifies land borders at higher risk of non-native vertebrate invasion and identifies human and environmental factors that predict risk hotspots.

The large low-shear-velocity anomalies in the deep lower mantle below 2300 km depth may relate to H₂O-induced ferrous iron stability in bridgmanite, according to laser-heated diamond anvil cell experiments.

A novel resistance gene against maize rough dwarf disease was identified, which confers broad resistance to the virus pathogen infecting multiple cereal crops by regulating jasmonic acid (JA) biosynthesis and JA-mediated defence response.

Designing photocatalysts to enhance the efficiency of non-oxidative coupling of methane is a challenging task. Here, the authors report that the anatase TiO₂ with exposed {101} facets and Pd co-catalyst enables efficient and selective methane coupling to ethane via a heterogeneous-homogeneous hybrid reaction pathway.

Inward-rectifier K⁺ channels respond to voltage via blockage by intracellular polyamines. How these blockers work is not entirely clear. Now a crystal structure of the cytoplasmic portion of Kir3.1 reveals five ion sites, and functional analyses indicate these ions are displaced by spermine binding.

SsPEIE1 is an essential virulence factor of Sclerotinia sclerotiorum. SsPEIE1 interacts with the key immune factor AtHIR4 and inhibits AtHIR4 oligomerization-mediated immune responses in Arabidopsis, thereby promoting S. sclerotiorum infection.

The mouse neocortex supports sensory performance through transient increases in sensory coding redundancy, neural codes that are robust to cellular variability, and inter-area fluctuation modes that transmit sensory data and task responses in non-interfering channels.

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Cytotoxic chemotherapy remains the standard treatment for triple negative breast cancer (TNBC), an aggressive subtype of breast cancer associated with poor prognosis. Here the authors report the results of a phase 1b trial of the liposomal irinotecan HE072 in patients with metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy.