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Scientific Reports (19)
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Showing 1–50 of 61 results

Advanced filters: Author: Yichuan You Clear advanced filters

Trim15 stabilizes VDAC3 via ubiquitination to suppress autophagy and enhance chemosensitivity in hypopharyngeal squamous cell carcinoma

Guangyi Wang
Yibang Shen
Jisheng Zhang
ResearchOpen Access30 Jan 2026
Cell Death Discovery

P: 1-12
A systematic review of AI for predicting glaucoma progression: challenges and recommendations towards clinical implementation

Yichuan G. Liang
Leo Fan
Andrew J. R. White
ResearchOpen Access22 Jan 2026
npj Digital Medicine

P: 1-18
Decoding necrosome assembly: harmonizing signal amplification and attenuation through optimal RIP3 stoichiometry

Signalosomes amplify cellular responses, but how they avoid uncontrolled activation is unclear. The authors use quantitative super-resolution imaging and mathematical modeling to reveal optimal RIP3:RIP1 ratios that ensure precise cell death signaling.

Xiang Li
Yating Cao
Xin Chen
ResearchOpen Access23 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Untethered soft microrobot driven by a single actuator for agile navigations

Replicating the swift navigation and robustness of cockroaches in untethered microrobots around 1 gram is challenging. The authors designed a microrobot with a single actuator, achieving high speed, agility, and resilience, even after being stepped on.

Yichuan Wu
Lai Cao
Bei Peng
ResearchOpen Access25 Jul 2025
Nature Communications

Volume: 16, P: 1-10
Lower limb asymmetries in elite junior female vault gymnasts

Zhengyang Zhao
Xiaomei Wei
Yingjun Nie
ResearchOpen Access16 Dec 2025
Scientific Reports

Volume: 15, P: 1-12
Split crRNA with CRISPR-Cas12a enabling highly sensitive and multiplexed detection of RNA and DNA

CRISPR-Cas12a nucleic acid detection largely involves pre-amplification and is limited in its ability to directly detect RNA. Here, authors present a split Cas12a system that enables direct, highly sensitive, and cost-effective detection of both DNA and RNA without amplification.

Yichuan Chen
Xinping Wang
Yi Liu
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-12
Efficient nonlinear function approximation in analog resistive crossbars for recurrent neural networks

The authors experimentally demonstrate the implementation of a non-linear activation function integrated with a ramp analog-to-digital conversion at the periphery of the memory to improve in-memory implementation of recurrent neural networks.

Junyi Yang
Ruibin Mao
Arindam Basu
ResearchOpen Access29 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Temperature-related hospitalization burden under climate change

Temperature-related risks among the climate-sensitive diseases in northwestern and southwestern China have been historically high, with associated hospitalization burdens projected to rise consistently.

Shujie Liao
Wei Pan
Xinghuan Wang
ResearchOpen Access16 Jul 2025
Nature

Volume: 644, P: 960-968
Correction: Long noncoding RNA LINC00857 promotes pancreatic cancer proliferation and metastasis by regulating the miR-130b/RHOA axis

Peng Chen
Zhirui Zeng
Zhangxia Ren
Amendments and CorrectionsOpen Access28 Jan 2026
Cell Death Discovery

Volume: 12, P: 1-3
PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer

Despite being an effective treatment for hepatocellular carcinoma (HCC), resistance to oxaliplatin presents a major obstacle. Here, the authors identify PRMT3-induced methylation of IGF2BP1 resulting in HEG1 stabilisation as a mechanism of oxaliplatin resistance in HCC.

Yunxing Shi
Yi Niu
Binkui Li
ResearchOpen Access06 Apr 2023
Nature Communications

Volume: 14, P: 1-17
Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progression

Crystalline silica particle exposure in the airways can lead to lung silicosis and progressive fibrosis. Here the authors use mouse silicosis models to show mechanics activated fibroblasts promote conversion of ILC2 to ILC1-like cells pulmonary fibrosis and that this is associated with a Notch3-IL-18 signalling pathway.

Yangyang He
Fan Yang
Chao Li
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Electric field control of Néel spin–orbit torque in an antiferromagnet

A ferroelectric material is used to switch the uniaxial magnetic anisotropy of an antiferromagnet, with implications for antiferromagnetic spintronics.

Xianzhe Chen
Xiaofeng Zhou
Feng Pan
Research08 Jul 2019
Nature Materials

Volume: 18, P: 931-935
Ultra-flexible porous magnetorheological elastomers with controllable pore parameters

Magnetorheological elastomers have useful magnetic-responsive properties, but often suffer from high stiffness due to magnetic fillers. Here, a pore-engineering approach achieves a Young’s modulus 15% of the value for the non-porous equivalent, allowing gradient structures to be synthesized.

Hang Ren
Dan Zhao
Yichuan Zhong
ResearchOpen Access13 Nov 2025
Communications Materials

Volume: 6, P: 1-12
Inflammatory mediation by neutrophil percentage to albumin ratio in the association between chronic kidney disease and presbycusis

Qingling Wang
Ruizhe Huang
Liwei Jiang
ResearchOpen Access17 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
scButterfly: a versatile single-cell cross-modality translation method via dual-aligned variational autoencoders

Technical limitations of simultaneously multi-omics profiling lead to highly noisy multi-modal data and substantial costs. Here, authors proposed a versatile framework and data augmentation schemes, capable of single-cell cross-modality translation and multiple extensive applications.

Yichuan Cao
Xiamiao Zhao
Shengquan Chen
ResearchOpen Access06 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations

Here the authors report a computational approach which integrates deep learning and structural modelling to design target-specific peptides. They apply this to β-catenin and NF-κB essential modulator, resulting in improved binding, highlighting the efficacy of this strategy.

Sijie Chen
Tong Lin
Xiaolin Cheng
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-20
A multi-perspective qualitative study on robotic-assisted surgery training demand

Xinling Tian
Kongying Nong
Xiaohong Tang
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Active oxygen species mediate the iron-promoting electrocatalysis of oxygen evolution reaction on metal oxyhydroxides

The authors systematically and unambiguously correlate the electrocatalytic activity of binary metal oxyhydroxides supported FeOxHy with active oxygen species, and show when and how the active oxygen species are involved during the oxygen evolution reaction process

Qu Jiang
Sihong Wang
Fang Song
ResearchOpen Access26 Oct 2023
Nature Communications

Volume: 14, P: 1-9
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.

Tao Yu
Shucheng Gan
Yichuan Xiao
ResearchOpen Access25 Sept 2019
Nature Communications

Volume: 10, P: 1-15
The public perception and adaptability of laws and regulations of autonomous driving vehicles

Yichuan Yang
Zongyu Song
ResearchOpen Access01 Aug 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-12
Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase

Ethylene is a plant hormone that promotes fruit ripening. Here, the authors identify pyrazinamide, a drug used to treat tuberculosis, as an inhibitor of ethylene biosynthesis inArabidopsis thalianaand present the crystal structure of its active form (pyrazinecarboxylic acid) bound to ACC oxidase.

Xiangzhong Sun
Yaxin Li
Hongwei Guo
ResearchOpen Access12 Jun 2017
Nature Communications

Volume: 8, P: 1-14
ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression

The accumulation of myeloid derived suppressor cells (MDSC) has been associated with prostate cancer progression and castration resistance. Here the authors show that loss of ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, results in polymorphonuclear-MDSC infiltration and cooperates with Pten loss to accelerate prostate tumorigenesis.

Ni Li
Qiuli Liu
Jun Qin
ResearchOpen Access26 Nov 2022
Nature Communications

Volume: 13, P: 1-20
Chromosome-level genome assembly of the caddisfly Stenopsyche angustata (Insecta: Trichoptera)

Yujun Wang
Xinze Liu
Hong Wang
ResearchOpen Access01 Sept 2025
Scientific Data

Volume: 12, P: 1-7
Suppressed phase separation of mixed-halide perovskites confined in endotaxial matrices

The bandgap of mixed-halide perovskites can be continuously tuned by changing the halide ratio, but the crystals have poor photo-stability. Here the authors show that photoinduced phase separation is suppressed when perovskite nanocrystals are embedded in a non-perovskite endotaxial matrix.

Xi Wang
Yichuan Ling
Hanwei Gao
ResearchOpen Access11 Feb 2019
Nature Communications

Volume: 10, P: 1-7
BDS-Adam optimizer integrating adaptive variance rectification with semi-adaptive gradient smoothing

Yichuan Shao
Shiqian Weng
Lei Xing
ResearchOpen Access22 Oct 2025
Scientific Reports

Volume: 15, P: 1-18
Health risk stratification based on computed tomography pulmonary artery obstruction index for acute pulmonary embolism

Fei Guo
Guanghui Zhu
Yichuan Ma
ResearchOpen Access17 Dec 2018
Scientific Reports

Volume: 8, P: 1-8
Mitochondrial DNA haplogroups and risk of attention deficit and hyperactivity disorder in European Americans

Xiao Chang
Yichuan Liu
Hakon Hakonarson
ResearchOpen Access02 Nov 2020
Translational Psychiatry

Volume: 10, P: 1-6
Toward improved trade-off between thermoelectric and mechanical performances in polycarbonate/single-walled carbon nanotube composite films

Yichuan Zhang
Liang Deng
Guangming Chen
ResearchOpen Access02 Oct 2020
npj Flexible Electronics

Volume: 4, P: 1-7
Causal relationship between immune cells and osteoporosis based on genetic prediction: a bidirectional two-sample mediated Mendelian randomization analysis

Hao Wang
Zehao Yu
Yanguo Qin
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Investigation of the cytotoxic effects and mechanisms of the SLC39A6-targeting ADC drug BRY812 in CRC

Xianglin Liu
Wenqiang Liu
Liqiang Hao
ResearchOpen Access25 May 2025
Scientific Reports

Volume: 15, P: 1-15
Deep learning algorithms reveal genomic markers for anxiety disorder in a large cohort of children with down syndrome

Yichuan Liu
Hui-Qi Qu
Hakon Hakonarson
ResearchOpen Access24 May 2025
Molecular Psychiatry

Volume: 30, P: 4710-4719
Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk

Chromosomal abnormalities such as 11q deletion are associated with poor prognosis in neuroblastoma. Here, the authors perform a genome-wide association study and identify an association between a variant within a Matrix metalloproteinase (MMP) gene member, MMP20, and 11q-deletion subtype neuroblastoma.

Xiao Chang
Yan Zhao
Hakon Hakonarson
ResearchOpen Access18 Sept 2017
Nature Communications

Volume: 8, P: 1-7
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability

Macrophage metabolism controls differentiation and subsequent adaptive immune responses. Here the authors show that mitochondrial membrane protein Fam73b regulates TLR-mediated mitochondrial switching of fusion to fission to induce IL-12 production via accumulation of Parkin and stabilization of IRF1 in macrophages, resulting in control of anti-tumor immunity in mice.

Zhengjun Gao
Yiyuan Li
Jin Jin
ResearchOpen Access27 Nov 2017
Nature Communications

Volume: 8, P: 1-13
Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disorder mediated by excessive autoantibodies. Here the authors show that an E3 ubiquitin ligase, Peli1, negatively modulates noncanonical NF-κB signaling to restrain lupus-like symptoms in mice, and that Peli1 expression inversely correlates with SLE severity in humans.

Junli Liu
Xinfang Huang
Yichuan Xiao
ResearchOpen Access19 Mar 2018
Nature Communications

Volume: 9, P: 1-13
A randomized controlled trial of an online health tool about Down syndrome

Jeanhee Chung
Karen Donelan
Brian G. Skotko
Research03 Sept 2020
Genetics in Medicine

Volume: 23, P: 163-173
Effects of key physiological parameters on cardiovascular disease and osteoporosis risk in perimenopausal and postmenopausal women

Hong Mou
Jun Zhang
Xiaoyan Luo
ResearchOpen Access22 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Crystalline silica-induced recruitment and immuno-imbalance of CD4⁺ tissue resident memory T cells promote silicosis progression

Crystalline silica exposure led to CD4⁺ tissue-resident memory T-cell accumulation. The imbalance of pulmonary T_RM-Teffs and T_RM-Tregs promoted silicosis progression. Neutralizing IL-7 alleviated silicosis by disrupting T_RM-Teff maintenance.

Yichuan You
Xiulin Wu
Chao Li
ResearchOpen Access09 Aug 2024
Communications Biology

Volume: 7, P: 1-14
Publisher Correction: Effects of key physiological parameters on cardiovascular disease and osteoporosis risk in perimenopausal and postmenopausal women

Hong Mou
Jun Zhang
Xiaoyan Luo
Amendments and CorrectionsOpen Access25 Mar 2025
Scientific Reports

Volume: 15, P: 1-2
The dominant role of aerosol’s CCN effect in cloud glaciation

Iqra Munawar
Yannian Zhu
Yichuan Wang
ResearchOpen Access26 Mar 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-8
Genetic and virulence characteristics of a Raoultella planticola isolate resistant to carbapenem and tigecycline

Ying Li
Yichuan Qiu
Luhua Zhang
ResearchOpen Access09 Mar 2022
Scientific Reports

Volume: 12, P: 1-13
Mycobacterium tuberculosis peptide E7/HLA-DRB1 tetramers with different HLA-DR alleles bound CD4⁺ T cells might share identical CDR3 region

Yichuan Gan
Cong Wang
Xiaomin Lai
ResearchOpen Access02 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
Non-coding structural variation differentially impacts attention-deficit hyperactivity disorder (ADHD) gene networks in African American vs Caucasian children

Yichuan Liu
Xiao Chang
Hakon Hakonarson
ResearchOpen Access17 Sept 2020
Scientific Reports

Volume: 10, P: 1-8
ParseCNV2: efficient sequencing tool for copy number variation genome-wide association studies

Joseph T. Glessner
Jin Li
Hakon Hakonarson
Research01 Nov 2022
European Journal of Human Genetics

Volume: 31, P: 304-312
FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP

Martina Tufano
Laura Marrone
Simona Romano
ResearchOpen Access13 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-12
A new class A beta-lactamase gene bla_CAE-1 coexists with bla_AFM-1 in a novel untypable plasmid in Comamonas aquatica

Ying Li
Chengju Fang
Luhua Zhang
ResearchOpen Access03 Mar 2023
Scientific Reports

Volume: 13, P: 1-10
NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3

Yuanping Zhang
Dinglan Zuo
Binkui Li
ResearchOpen Access04 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-11
Intestinal preservation in a birdlike dinosaur supports conservatism in digestive canal evolution among theropods

Xuri Wang
Andrea Cau
Yichuan Liu
ResearchOpen Access19 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Single-cell sequencing unveils key contributions of immune cell populations in cancer-associated adipose wasting

Jun Han
Yuchen Wang
Qiurong Ding
ResearchOpen Access15 Nov 2022
Cell Discovery

Volume: 8, P: 1-22
METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m⁶A-YTHDF2-dependent manner

Jiaren Li
Hanyu Yao
Long Wang
ResearchOpen Access19 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-14
Long noncoding RNA LINC00857 promotes pancreatic cancer proliferation and metastasis by regulating the miR-130b/RHOA axis

Peng Chen
Zhirui Zeng
Zhangxia Ren
ResearchOpen Access13 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-13

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