Nature Search

Regulating Pb off-centering distortion for white-light emission in 2D halide perovskites

Leveraging electron-phonon coupling allows for modulating self-trapped exciton formation for broadband white-light emission. Using transient spectroscopy and DFT calculations, Zhang et al. correlate the structural distortion with self-trapped exciton formation in 2D halide perovskites.

Yutong Zhang
Yuanyuan Guo
Xinfeng Liu
ResearchOpen Access21 Jan 2026
Nature Communications

P: 1-11
A three-tier AI solution for equitable glaucoma diagnosis across China’s hierarchical healthcare system

Yi Zhou
Haitao Nie
Weitao Song
ResearchOpen Access03 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-15
Horizontally oriented compact colloidal quantum well films enable efficient and stable electroluminescent diodes

Ba et al. report a scalable approach combining two-phase driving and Langmuir–Schaefer deposition, enabling colloidal quantum well films with 90% horizontal dipole alignment, yielding red LEDs with EQE of 25.5%, luminance of 59,620 cd m⁻², stability over 16,233 h, and maintaining the luminance when scaling the device area to 4 cm².

Guohang Ba
Yiyang Gong
Jianjun Tian
ResearchOpen Access01 Dec 2025
Nature Communications

Volume: 16, P: 1-10
Fastest-ever calcium sensors broaden the potential of neuronal imaging

Proteins have been developed that emit flashes of light in response to influxes of calcium ions into cells on millisecond timescales. Two sets of scientists discuss the legacy and future of these proteins.

Michael B. Ryan
Anne K. Churchland
Casey Baker
News & Views15 Mar 2023
Nature

Volume: 615, P: 804-805
Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates

FcγRIIb captures its ligand and targets it to lysosomal degradation following endocytosis. Here authors design bispecific-antibody-like molecules they call FcγRIIb-targeting chimeras or FcRTACs, to capture antigens with one arm and degrade them via an FcγRIIb-binding second arm to promote the clearance of pathological protein aggregates.

Mingjuan Du
Na Li
Hongkai Zhang
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Structural variation drives enhancer hijacking via 3D genome disruption in ccRCC

Yu Dong
Wenjiao Xia
Cheng Zhang
ResearchOpen Access06 Jan 2026
npj Digital Medicine

Volume: 9, P: 1-22
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Imaging neural spiking in brain tissue using FRET-opsin protein voltage sensors

Genetically encoded optical voltage sensors measure the electrical activity of various tissues with limited effectiveness, due to the sensors’ suboptimal performance metrics. Gong et al.create a sensor with increased brightness, fast kinetics and improved dynamic ranges when compared with previous sensors.

Yiyang Gong
Mark J. Wagner
Mark J. Schnitzer
Research22 Apr 2014
Nature Communications

Volume: 5, P: 1-11
Joint estimation of SOC and SOH for lithium-ion batteries based on FOAMIUHF-UKF model

Zheng Ye
ZhiHui Deng
MengXiang Yan
ResearchOpen Access19 Nov 2025
Scientific Reports

Volume: 15, P: 1-22
Topological prethermal strong zero modes on superconducting processors

Stable and robust topological edge modes are observed at finite temperatures in an array of 100 programmable superconducting qubits because of emergent symmetries present in the prethermal regime of this system.

Feitong Jin
Si Jiang
Dong-Ling Deng
ResearchOpen Access27 Aug 2025
Nature

Volume: 645, P: 626-632
Segmentation of neurons from fluorescence calcium recordings beyond real time

Calcium imaging is a valuable tool for recording in vivo neural activity, but the task of extracting signals of individual neurons is computationally challenging. Bao and colleagues present a U-Net-based method that is both accurate and fast enough to potentially allow real-time processing and closed-loop experiments.

Yijun Bao
Somayyeh Soltanian-Zadeh
Yiyang Gong
Research20 May 2021
Nature Machine Intelligence

Volume: 3, P: 590-600
Boosting exciton mobility approaching Mott-Ioffe-Regel limit in Ruddlesden−Popper perovskites by anchoring the organic cation

Exciton transport in 2D Ruddlesden−Popper perovskite plays a key role for their optoelectronic performance. Here, authors significantly enhance free exciton mobilities in exfoliated thin flakes by anchoring butyl ammonium cation with polymethyl methacrylate, which also improves lattice rigidity.

Yiyang Gong
Shuai Yue
Xinfeng Liu
ResearchOpen Access29 Feb 2024
Nature Communications

Volume: 15, P: 1-8
Isomeric diammonium passivation for perovskite–organic tandem solar cells

A new surface passivator cyclohexane 1,4-diammonium diiodide naturally contains two isomeric structures with ammonium groups on the same or opposite sides of the hexane ring, and the two isomers demonstrate completely different surface interaction behaviours.

Xin Jiang
Shucheng Qin
Yongfang Li
Research14 Oct 2024
Nature

Volume: 635, P: 860-866
A community effort to optimize sequence-based deep learning models of gene regulation

A benchmarking competition improves tools that predict how regulatory regions control gene expression.

Abdul Muntakim Rafi
Daria Nogina
Carl G. de Boer
ResearchOpen Access11 Oct 2024
Nature Biotechnology

Volume: 43, P: 1373-1383
Accurate neuron segmentation method for one-photon calcium imaging videos combining convolutional neural networks and clustering

SUNS2-ANE segments active neurons from one-photon calcium imaging videos accurately and fast. It improves background suppression and extracts additional weak neurons. A separate semi-automatic labeling pipeline generates ground truth for training.

Yijun Bao
Yiyang Gong
ResearchOpen Access09 Aug 2024
Communications Biology

Volume: 7, P: 1-16
Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle

Xia et al. provide a method for deep learning of 3D facial images to predict biological age with an accuracy of ±2.8 yr from chronological age and its correlation with lifestyle indicators and blood transcriptomic age.

Xian Xia
Xingwei Chen
Jing-Dong J. Han
Research07 Sept 2020
Nature Metabolism

Volume: 2, P: 946-957
Rational engineering of ratiometric calcium sensors with bright green and red fluorescent proteins

Zhang, Redington & Gong develop FRET-based ratiometric calcium sensors with pairs of green and red fluorescent proteins. Their best performers, Twitch-GR and Twitch-NR inherit the superior photophysical properties of their constituent fluorescent proteins, enabling them to outperform existing ratiometric calcium sensors in brightness, photobleaching, and signal fidelity metrics.

Diming Zhang
Emily Redington
Yiyang Gong
ResearchOpen Access29 Jul 2021
Communications Biology

Volume: 4, P: 1-12
Long-term optical brain imaging in live adult fruit flies

Time-lapse imaging studies of more than a day in the fly brain have been infeasible until now. Here the authors present a laser microsurgery approach to create a permanent window in the fly cuticle to enable time-lapse imaging of neural architecture and dynamics for up to 10–50 days.

Cheng Huang
Jessica R. Maxey
Mark J. Schnitzer
ResearchOpen Access28 Feb 2018
Nature Communications

Volume: 9, P: 1-10
Improving FRET dynamic range with bright green and red fluorescent proteins

Development of the bright green and red fluorescent proteins, Clover and mRuby2, creates a fluorescence resonance energy transfer (FRET) pair with the highest Förster radius among existing ratiometric FRET pairs. Substitution of this pair for current FRET pairs in several existing sensors reliably and substantially improves sensor performance.

Amy J Lam
François St-Pierre
Michael Z Lin
Research09 Sept 2012
Nature Methods

Volume: 9, P: 1005-1012
Stretchable multifunctional wearable system for real-time and on-demand thermotherapy of arthritis

Zehan Liu
Xihan Wang
Junshan Liu
ResearchOpen Access13 May 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-12
A fully water coupled oblique light-sheet microscope

Yiyang Gong
Yuqi Tian
Casey Baker
ResearchOpen Access08 Apr 2022
Scientific Reports

Volume: 12, P: 1-11
Kilohertz two-photon brain imaging in awake mice

A multi-beam two-photon microscope enables imaging of calcium activity or neurovascular dynamics in the brain with millisecond-scale temporal resolution.

Tong Zhang
Oscar Hernandez
Mark J. Schnitzer
Research28 Oct 2019
Nature Methods

Volume: 16, P: 1119-1122
A high-speed, bright, red fluorescent voltage sensor to detect neural activity

Connor Beck
Yiyang Gong
ResearchOpen Access04 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor

In this technical report, St-Pierre and colleagues introduce a new genetically encoded voltage sensor called Accelerated Sensor of Action Potentials 1 (ASAP1), which consists of a circularly permuted GFP inserted in the extracellular voltage-sensing domain of a phosphatase. ASAP1 surpasses existing sensors in reliably detecting single action potentials and tracking subthreshold potentials and high-frequency spike trains.

François St-Pierre
Jesse D Marshall
Michael Z Lin
Research22 Apr 2014
Nature Neuroscience

Volume: 17, P: 884-889
Haploidentical-cord blood stem cell transplantation versus haploidentical stem cell transplantation for non-CR acute leukemia patients: a multicenter study

Jinjin Zhu
Mimi Xu
Depei Wu
Correspondence19 Jun 2024
Bone Marrow Transplantation

Volume: 59, P: 1320-1322
A longitudinal resource for population neuroscience of school-age children and adolescents in China

Xue-Ru Fan
Yin-Shan Wang
Xi-Nian Zuo
ResearchOpen Access21 Aug 2023
Scientific Data

Volume: 10, P: 1-24
The role of m⁶A modification in physiology and disease

Chuan Yang
Yiyang Hu
Yufeng Xiao
ReviewsOpen Access08 Nov 2020
Cell Death & Disease

Volume: 11, P: 1-16

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