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Advanced filters: Author: Yoko Masui Clear advanced filters

Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer

Desmoplastic stroma is a hallmark of aggressive colorectal cancer. Matrix cancer-associated fibroblasts derived THBS2 establishes a fibrotic, immune-exclusionary barrier that limits CD8⁺ T cell infiltration, while its inhibition restores CXCR3-mediated T cell recruitment and enhances response to immune checkpoint blockade.

Kosuke Iwane
Yuki Nakanishi
Hiroshi Seno
ResearchOpen Access23 Nov 2025
Nature Communications

Volume: 16, P: 1-20
Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages

Polycomb repressive complexes 1 and 2 both regulate maintenance of X inactivation in extra-embryonic lineages of post-implantation embryos by affecting overlapping yet different genes, thus implying potentially independent roles for the two complexes.

Osamu Masui
Catherine Corbel
Edith Heard
Research12 Jan 2023
Nature Cell Biology

Volume: 25, P: 134-144
Selection of anti-cytokine biologics by pretreatment levels of serum leucine-rich alpha-2 glycoprotein in patients with inflammatory bowel disease

Takahiro Amano
Takeo Yoshihara
Tetsuo Takehara
ResearchOpen Access29 Nov 2024
Scientific Reports

Volume: 14, P: 1-11

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