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Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

Tumor-infiltrating T cells (TIL) are key mediators of the anti-tumor immune responses. However, chronic exposure to tumor antigens leads to the acquisition of an exhausted phenotype. Here, the authors present a bispecific T-cell engager that combines an anti-TIM-3 antibody with an IFN-α fusion protein (BiDT) and facilitates T cell-dendritic cells (DC) interactions. In preclinical mouse models, the enhanced T cell-DC crosstalk, dependent on CD28 co-stimulation and IL-2 signaling, boosts anti-tumor immunity and the generation of memory T cell responses.

A “confined molecular encapsulation” strategy enables one-step fabrication of biomimetic ion-selective membranes. The in-situ formed MOFs with tunable sizes facilitate highly precise ion differentiation.

Achieving simultaneous flexibility, thermal stability and strong absorption in conventional X-ray sensors is challenging. Here, the authors develop an all-inorganic fabric X-ray sensor working from 80 K to 1373 K, enabling real-time imaging of molten metals and superconducting magnets.

Neutrophils are known to be important in COPD pathogenesis and calcium signaling is involved in this process. Here the authors examine the function of Na⁺Ca²⁺ exchanger 1 (NCX1) in neutrophil function in mouse models of chronic cigarette smoke exposure and show that inhibition of NCX1 reduces neutrophil accumulation in the lungs and formation of neutrophil extracellular traps (NETs).

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Here the authors show that marine diatoms produce tryptophanol, a molecule that at extremely low concentrations rapidly activates nitrogen assimilation genes and enzymes. This facilitates acquisition of nitrogen, a vital ocean nutrient.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

FOXA1 is a master suppressor of prostate cancer tumorigenesis and lineage plasticity. Here, the authors discover that FOXA1 loss in mice drives basal-squamous de-differentiation and remodels the tumor microenvironment characterized by immunosuppressive myeloid cell accumulation and T-cell dysfunction.

Women with diminished ovarian reserve face persistently low success rates during in vitro fertilization. Here, the authors show that a modified letrozole protocol yields cumulative clinical pregnancy rates and cumulative live birth rates comparable to those of the GnRH antagonist protocol.

CDK4/6 inhibitors response is limited by frequent resistance in hormone receptor– positive cancers. Here, the authors show that a super enhancer driven increase in aldehyde dehydrogenase creates a vitamin A/retinoic acid feedback loop that promotes resistance in breast and endometrial cancer.

Neural mechanisms underlying social behavior are not fully understood. Here authors show two lateral septum neuron types in male mice that bidirectionally regulate social memory via distinct hippocampal-hypothalamic circuits.

Ordered antihedgehog polar lattices are engineered in antiferroelectric PbZrO₃ thin films via interfacial dislocation networks. The authors reveal that these ordered topological structures originate from mismatch.

Near-infrared-II carbon dots offer exceptional deep-tissue penetration for biomedical imaging, but challenges remain in their synthesis and photoluminescence mechanisms. In this work, the authors designed and synthesized a series of carbon dots (CDs-1 to CDs-3) through extension of aniline-based frameworks, achieving tunable emission extending into the NIR-II region, and applied these CDs in deeptissue NIR-II imaging of the hepatobiliary system.

mRNA vaccines hold promise as cancer therapeutics. However, production complexity and prohibitive manufacturing costs limit the applicability of these vaccine platforms. Here, the authors present an engineered linear Cap-independent mRNA vaccine design that achieves stable in vivo expression and elicits robust anti-tumor immune responses in preclinical mouse models.

Developing durable, water-repellent textiles without using harmful fluorinated chemicals is challenging. Here, authors use a one-step molecular assembly to covalently bond superhydrophobic silica shells directly onto fibers, resulting in high wear resistance and breathability.

Nociceptive hypersensitivity and prolonged wound healing due to the interaction of peripheral neuropathy and local immune disorders hinder the regenerative repair of diabetic foot ulcer. Here, the authors report a low-intensity focused ultrasound-activated piezoelectric gel bandage with immune homeostasis modulation and neuropathic pain relief functions for comprehensive repair of diabetic wounds.

Oncolytic viruses are an approved therapeutic approach for glioblastoma, but, unfortunately, they are efficacious only in some patients. Here, the authors discover that LRRK2 inhibitors enhance viral infection and oncolysis by oncolytic herpes simplex virus (oHSV) in glioblastoma.

The piezoelectricity of ferroelectric oxide films is limited by substrate clamping, and their rigidity hinders their applications in flexible electronics. Herein, authors report freestanding PbZr0.52Ti0.48O3 nanoscale membranes with both high piezoelectricity and high flexibility.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

The practical application of photocatalytic uranium removal is hampered by the inefficient charge separation of electron-hole pairs in photocatalytic systems, which limits the generation of reactive oxygen species needed for uranium precipitation. Here, the authors show that weakly localized electrons enhance the electronic coherence in fluorine-functionalized covalent organic frameworks strengthening charge separation and promoting directional electron transport to boost the photocatalytic uranium removal from nuclear wastewater.

Electrochemical advanced oxidation water treatment processes (EAOPs) can help achieve a sustainable water cycle but remain challenging to scale up and implement. This study presents a flow-through EAOP device design that features good scalability and exhibits high practical application potential.

Perovskite–organic-based solar cells typically show poor reverse-bias stability. By modulating the deep trap state in the bulk-heterojunction region, organic and perovskite–organic tandem solar cells show largely improved stability under reverse biases up to –40 V.

Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The exchange is needed for testosterone production.

GLT25D1 galactosylates collagen hydroxylysines and is essential for collagen maturation. Here, authors trap multiple functional states of GLT25D1 to elucidate its molecular mechanism, providing mechanistic insights into GLT25D1-related diseases.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

Exhausted CD8⁺ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.

Femtosecond laser pulse-induced coherent helicity switching of magnetic vortices in permalloy disks on picosecond timescales is reported.

Many vascular‑disease risk loci lack defined causal genes. Here, the authors integrate functional genomics and CRISPR screens to identify genes influencing smooth muscle cell behaviour, validating roles for FES, BCAR1, CARF and SMARCA4, with Fes loss promoting atherosclerosis and hypertension.

Malignant pleural effusion is a challenge for cancer therapy. Here, the authors report on a piezoelectric nano-system that inhibits tumor growth in the thoracic cavity by piezo-generated reactive oxygen species using the intrapleural pressure, triggering immunogenic cell death, to treat malignant pleural effusion.

Bioisosteric replacement of benzenes with caged hydrocarbons can form enhanced lead compounds with improved drug-like properties, but synthetic challenges limit their application. Now, a collective strategy for synthesizing saturated bioisosteres of 1,2,4-trisubstituted and disubstituted benzenes has been developed. This strategy involves constructing 2-thiabicyclo[3.1.1]heptane scaffolds via cycloaddition of bicyclo[1.1.0]butanes and mercaptoacetaldehyde.

While blue space has been linked to metabolic health, research has primarily focused on water quantity rather than quality. This study finds that lower water coverage and higher exposure to black-odorous water increase risk of metabolic syndrome.

The two-dimensional semiconductor Bi₂O₂Se can be oxidized to create an atomically thin layer of Bi₂SeO₅ that can be used as the insulator in scaled field-effect transistors.

Bone marrow ssDNA, specifically EHBP1-ssDNA, drives prostate cancer bone metastasis via integrin α6-FAK signaling, and Defactinib blocks this pathway.

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

Traditional iterative catalysis in RiPP biosynthesis typically modifies linear peptides. Here the authors discover GNAT enzymes that iteratively modify fully folded lasso peptides and engineer them to create lipolasso peptides with expanded chemical diversity.

A two-dimensional/two-dimensional contact of metallic Nb_0.3W_0.7Se₂ and tungsten diselenide can be used to make p-type transistors with channel lengths of 100 nm and on-currents of over 1.1 mA µm⁻¹.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Low glume coverage is the preferred for easy threshing in grain production, but the genetic basis remains unclear. Here, the authors report the gene GC1, which encodes an atypical G protein γ subunit, negatively regulates sorghum glume coverage and the naturally truncated alleles can be useful in the naked grain breeding.

The authors mapped the continental-scale fraction of age-dependent leaf area index and revealed a widespread increase in the fraction of photosynthetically efficient young leaves across the majority of Amazon rainforests over the past decades.