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Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

The manuscript describes two pathogenic mutations in GTPBP3 that cause defects in mitochondrial tRNA taurine modification, mitochondrial translation, structure and function. Mutant mice reproduce certain clinical features seen in patients and this can be reversed by virus-mediated exogenous expression of Gtpbp3.

Decoding skin gases can reveal a lot about our health. Here, the authors introduce a monolithic AI-powered wearable ring designed to non-invasively monitor dermal volatile-organic-compounds associated with diet-related metabolism.

Macrophages and lipid metabolism have an important function in atherosclerosis. Here, the authors characterise the function of chitinase-like protein 3 (CHIL3) or its human functional homologue chitinase-3-like 2 (CHI3L2), and show these proteins enhance atherogenesis in a macrophage dependent manner and function by hydrolysing glycans on CD36 which enhances lipid uptake, activates mTOR and inflammatory macrophage responses and suppresses PPARγ-ABCG1-mediated cholesterol efflux.

Peripheral nerve modulation is promising for regulating physiological functions, but its performance relies on a stable electrode–tissue interface. Here, the authors present a tissue-adaptive bioelectronic fiber that thermo-contracts at body temperature, forming robust biointerfaces. Incorporating carbon nanotubes enables mixed ionic–electronic conductivity, supporting reliable neural stimulation and 99.5% signal retention in sciatic nerve recordings under repeated activation.

Microcavity exciton polaritons are a promising platform for optical parametric processes. Here, authors achieve efficient parametric emission with strong phase coherence in quantum confined microcavities, demonstrating a polariton supersolid phase at room temperature.

Fe3GaTe2 is a room temperature van der Waals ferromagnet, which, despite having a centrosymmetric crystal structure, has both a large Dzyaloshinskii-Moriya interaction and hosts topological spin textures. Here, Xia, Luo, Malik and coauthors unravel this mystery, showing the critical role of field cooling in the breaking of inversion symmetry in Fe3GaTe2.

Protein oligomerization can regulate cellular functions. Here, authors identify a small molecule that selectively induces WDR5 oligomerization using nanopore screening and show it disrupts cancer-driving interactions, highlighting a potential anti-tumor strategy.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

Ordered antihedgehog polar lattices are engineered in antiferroelectric PbZrO₃ thin films via interfacial dislocation networks. The authors reveal that these ordered topological structures originate from mismatch.

Metabolic profiling of extracellular vesicles for diagnostic applications remains challenging. Here authors develop ACTIVITY, a cascade-catalysis strategy to detect metabolically active extracellular vesicles, enabling macrophage phenotyping and differentiation of pneumonia patients from healthy controls.

Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

Converting syngas into high-value long-chain alcohols is a major industrial challenge due to poor product selectivity. This study achieves 80% selectivity through a modular catalytic design that boosts carbon efficiency while minimizing waste.

The authors report a wavelength-gated regeneration strategy, where specific wavelength photogenerated carriers drive the reversible cycling of active sites, enabling highly stable photocatalytic CO₂ reduction to C₂H₆.

Hydrogen can permeate two-dimensional crystals like graphene in the form of protons at high rates, involving catalytic dissociation and recombination steps, with permeability tunable by material type, metal nanoparticles, or atmosphere, offering insights for separation membranes and energy technologies.

Tumor-infiltrating T cells (TIL) are key mediators of the anti-tumor immune responses. However, chronic exposure to tumor antigens leads to the acquisition of an exhausted phenotype. Here, the authors present a bispecific T-cell engager that combines an anti-TIM-3 antibody with an IFN-α fusion protein (BiDT) and facilitates T cell-dendritic cells (DC) interactions. In preclinical mouse models, the enhanced T cell-DC crosstalk, dependent on CD28 co-stimulation and IL-2 signaling, boosts anti-tumor immunity and the generation of memory T cell responses.

This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

The authors identify Npr1 as a nucleophagy receptor in fission yeast that acts redundantly with Epr1 to degrade nuclear components. Tethering chromatin to the inner nuclear membrane blocks nucleophagy, suggesting a genome protection mechanism.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

Social rewards hold therapeutic potential for alleviating drug relapse, yet the neural substrates remain unclear. Here, authors show that social reward and drug relapse activate distinct dopaminergic populations within the VTA, which dynamically compete to regulate behavioral outcomes.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The authors develop the equivariant tensor message-passing model LiTEN and its foundation model LiTEN-FF, which combine quantum-level precision with high computational efficiency to enable reliable simulations of complex biological systems.

The oxygen evolution reaction is hindered by slow proton transfer. Here, the authors report an ordered oxygen-down water layer that accelerates initial water deprotonation and proton transport, enabling low-voltage, durable membrane electrolysis at high current.

This study reveals that the brain encodes handwriting in multiple dimensions. The decoding paradigm, informed by movement data from healthy individuals, captures these full dimensions to enhance the performance of brain-to-text communication.

Nociceptive hypersensitivity and prolonged wound healing due to the interaction of peripheral neuropathy and local immune disorders hinder the regenerative repair of diabetic foot ulcer. Here, the authors report a low-intensity focused ultrasound-activated piezoelectric gel bandage with immune homeostasis modulation and neuropathic pain relief functions for comprehensive repair of diabetic wounds.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

BUSGen is a foundation generative model designed for analysing breast ultrasound images that supports diverse tasks and improves breast cancer screening, diagnosis and prognosis.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

Multi-trait genetic analysis in East Asians identifies a novel gastric cancer risk locus shared with cardiovascular traits and shows that this variant modulates regulation of nearby genes, including VEZT, with functional effects on gastric cancer cell behaviour.

Neutrophils are known to be important in COPD pathogenesis and calcium signaling is involved in this process. Here the authors examine the function of Na⁺Ca²⁺ exchanger 1 (NCX1) in neutrophil function in mouse models of chronic cigarette smoke exposure and show that inhibition of NCX1 reduces neutrophil accumulation in the lungs and formation of neutrophil extracellular traps (NETs).

This study shows that the intestine uses a specific pathway to generate the energy (ATP) needed to move dietary fat out of intestinal cells. A protein called ANKRD9 helps regulate this energy supply; without it, fat builds up in the intestine, and the body remains lean.

Room-temperature multiferroic materials are highly demanded for designing next-generation of spintronic devices. Here, the authors demonstrate an emergent room-temperature ferrimagnetism and polar phase in highly strained La₂CoRuO₆ epitaxial films through engineered 3d−4d cation ordering.

Photoredox catalysis promises transformative advances in proximity labeling and noninvasive therapy, yet photocatalysts rarely combine low-energy light absorption with high excited-state potentials. Here, the authors report Ru-based bio-photocatalysts that integrate greenlight absorption with strong redox power, enabling selective protein and phenol coupling.

Catalysts combining different active sites can enhance chemical reactions by activating multiple steps simultaneously. Herein, aluminum dual-atom sites paired with nickel nanoclusters enable efficient, selective acetylene hydrogenation under mild conditions.

Developing durable, water-repellent textiles without using harmful fluorinated chemicals is challenging. Here, authors use a one-step molecular assembly to covalently bond superhydrophobic silica shells directly onto fibers, resulting in high wear resistance and breathability.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.

Traditional nanopore sensors use barrel-shaped protein channels. Here, the authors report on a study into the use of globular protein, ferritin, as a nanopore sensor, demonstrating membrane insertion and sensor application, showing the potential of non-barrel-shaped proteins for nanopore sensing.

The study introduces polyethyleneimine as an additive in a thermocell, enhancing thermopower from 1.4 to 7.76 mV/K. It achieves long-term stability and scalability by enabling thermosensitive adsorption-desorption, selective reactions, and Manning condensation, converting low-grade heat to electricity efficiently.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Real-time spectrum sensing (RT-SS) is essential for 6G networks to dynamically manage spectral resources and support integrated sensing and communication. Here, the authors develop a thin film lithium niobate photonic system for wideband RT-SS up to 120 GHz with nanosecond-level latency.

Global cropland subsoil hides a “biogeochemical engine” where crop roots, soil texture, nitrifier communities, and hydrological conditions interact to fuel nitrification, silently driving soil acidification and groundwater nitrate pollution.

Metal–halide complexes are central to light emission in halide perovskites, but their bottom-up spatial arrangement is difficult to control. Now a crown-ether-assisted supramolecular strategy has been shown to enable the synthesis of one-dimensional metal–halide molecular wires with high photoluminescence efficiency and strong nonlinear optical responses.

A solar-powered strategy enables sustainable agriculture by integrating solar desalination, crop irrigation and food waste upcycling into an interconnected system, creating a circular economy for regions facing freshwater constraints.

Wearable inertial and soft sensors combined with a lightweight learning-based fusion framework achieve long-duration, accurate three-dimensional tracking of shoulder motion with minimal calibration.