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Intermittent fasting (IF) has been recognized as a potential cancer therapeutic approach but its effect on tumor growth is limited. This study demonstrates that response to IF varies between glioblastoma subtypes, with IF specifically inhibiting Tp53-driven glioblastoma due to a reshaping of the gut microbiota and subsequent altered methionine metabolism suppressing TGF- β signaling.

Short-circuiting during fast charging through lithium dendrite intrusion into electrolytes is a major challenge in solid-state batteries. Here, using thermally annealed 3-nm-thick Ag coatings, lithium penetration into brittle electrolyte Li_6.6La₃Zr_1.6Ta_0.4O₁₂ is inhibited at local current densities of 250 mA cm⁻² due to an increase in surface fracture toughness.

The quality of the Li–electrolyte interface is key to solid-state battery performance, especially at low pressure. Here, authors use operando electron microscopy to reveal how Li-Mg alloy anodes improve interfacial contact and low-pressure cycling stability by suppressing void formation.

By coordinating copper ions with the oxygen-containing groups of cellulose nanofibrils, the molecular spacing in the nanofibrils is increased, allowing fast transport of lithium ions and offering hopes for solid-state batteries.

A self-consistent model that bridges electrochemistry and solid-state physics is developed to fully describe the ion and electron distribution at solid electrode/electrolyte interfaces and applied to lower interfacial resistance in batteries.

For high-energy lithium-sulfur batteries, a dense electrode with low porosity is desired to minimize electrolyte intake, parasitic weight, and cost. Here the authors show the impact of porosity on the performance of lithium-sulfur batteries and reveal the mechanism through analytical modeling.

The existence (or not) of electronic coherence in homopolymers is dependent on a balance between monomer–monomer interactions and environmental heterogeneity. Now, by understanding how even–odd orbital symmetry influences coherence and produces resistance oscillations as a function of distance—it is shown that DNA sequences can be designed to support coherent charge transport.

Inspired by fish sensory systems, the authors develop a 3D-nanoprinted optical neuromast that enables sensitive, multifunctional underwater detection and communication, opening pathways for marine exploration and monitoring.

Liquid electrolytes in batteries are considered to be macroscopically homogeneous ionic transport media despite having a complex chemical composition and atomistic solvation structures. A micelle-like structure in a localized high-concentration electrolyte for which the solvent acts as a surfactant is reported.

An anti-4-1BB antibody fused to interleukin-15 via a peptide sensitive to tumour proteases augments tumour inhibition without increasing systemic toxicity by concurrently depleting regulatory T cells and expanding cytotoxic T cells in the tumours.

Comparison of single-cell m6A methods and development of a freely accessible database, Scm6A, enabling prediction and visualization of m6A modifications across human and mouse single-cell and spatial transcriptomes.

Song et al. quantify the signal of natural selection on 870 complex traits in European individuals, finding that 88% of traits showed signals of selection in the past 3,000 years, including traits related to pigmentation, body shape and food intake.

Studying the single-molecule behavior of host-guest complexes can provide fundamental insights into their supramolecular interactions. Here, the authors use the scanning tunneling microscopy break junction technique to show that encapsulation of a C₆₀ molecule significantly enhances the conductance of an organoplatinum metallocycle; mechanical stretching of the junction releases the guest, returning the conductance to free-host level.

Guanine-quadruplex motifs form multi-ended DNA junctions that transport electrical charges with minimal losses.

Knock-in mice conditionally or constitutively expressing Cas12 variants enable a wide range of ex vivo and in vivo applications requiring multiplexed genome engineering.

Mechanotransduction in endothelial cells is critical to maintain vascular homeostasis. Here, the authors show that the discoidin domain receptor 1 tyrosine kinase is a mechanosensor is essential for connecting the force imposed by shear to endothelial responses.

Understanding the thermoelectric effect of materials and molecules is important for understanding their charge transport properties. Here, the authors study the thermoelectric effect in single DNA molecules and show that the charge carrier properties are dependent on both the DNA length and sequence.

The solid–electrolyte interphase between the negative electrode and the electrolyte is vital to the performance of rechargeable batteries, yet it is challenging to quantify its physical properties. Now a way of directly measuring the electrical properties of the interphase has been devised, revealing voltage-dependent conducting behaviour.

The proteases of flaviviruses are promising targets for development of specific antiviral drugs. Here, the authors report a high resolution crystal structure of the NS2B-NS3 protease of Zika virus that provides insight into substrate and inhibitor binding.

Synaptotagmin-1 and -7 are calcium sensors that distinctly drive vesicular exocytosis. Here, using wild-type proteins but manipulating the composition of the target membranes, the authors show that synaptotagmin-7 is unusually robust at penetrating membranes.

Comparison of electrochemically gated charge transport through diphenyl benzene structures in meta and para configuration leads to the identification of anti-resonance features typical of destructive quantum interference.

Mouse models are an essential tool in breast cancer research. Here, the authors present the genomic and transcriptomic profiles of two widely used mouse models, revealing parallels with the human disease specifically with metastasis and treatment response.

Efficient electron-hole separation and carrier utilization are key factors in photosynthetic systems. Here, the authors achieve efficient charge separation following a photogenerated hole-transfer band-trap pathway in the ternary composite Pt@NH₂-UiO-66/CdS, resulting in photocatalytic hydrogen evolution with good stability and a quantum efficiency of 40.3% at 400 nm irradiation.

Thanks to its base stacking structure, DNA can behave as an electric wire, but external control of its electronic properties has not been achieved yet. Here, the authors show that DNA conductance can be switched electrochemically when a DNA base is replaced by the redox molecule anthraquinone.

The authors developed an optical imaging approach for mapping cortical functions through the intact skull in marmoset monkeys. Detailed functions and topographies were revealed in visual, auditory, and somatosensory cortices at mesoscopic scales.

Evolutionary arms races can drive adaptations in hosts and parasites as well as among competing parasites. A combination of multi-omics and functional tests identifies a set of genes that allow a parasitic wasp to minimize intraspecific competition by inducing hosts to escape before more wasps can parasitize them.

Layered materials held together by weak interactions can be exfoliated into monolayers that retain the structure and composition of their bulk counterpart, but this has remained challenging to achieve for non-van der Waals materials. Now, AgCrS₂ has been exfoliated into such [CrS₂]Ag[CrS₂] nanosheets through intercalation with tetraalkylammonium cations chosen for their suitable redox potential. The nanosheets show superionic behaviour at room temperature.

Parasitism is a widespread evolutionary strategy. A study that spans functional and evolutionary genomics identifies the molecular basis and history underlying two genes that have mediated divergent parasitic strategies (specialist vs generalist) between two sister species of parasitoid wasp.

Animals have evolved varied strategies for predator avoidance. Here the authors find that Drosophila can recognize threats from younger parasitoid wasps via the perception of their search performance, and reduce egg laying through the reduction of octopamine neuronal signalling.

Electrostrictors are materials that develop mechanical strain proportional to the square of the applied electric field. Here authors report. Zr-doped-Ceria as a new lead-free electrostrictive material with a similar electrostriction coefficient to the best electrostrictor material currently in use.

The crosslinking of oligomeric precursors, controlled by a capping agent, enables the production of moulded crystalline calcium carbonate with continuous structures.