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Tumor-associated macrophages play central roles in the cellular immune response in the tumor microenvironment. Here the authors implicate the m6A methyltransferase METTL3 in glioma progression by regulation of the ISG15/FASN modulated lipid metabolism in macrophage.

Grain number per panicle (GNP) is a critical yield component trait of rice. Here, the authors clone a MAPKKK encoding gene GNP3 positively regulating grain yield and show its role in rice panicle development by interacting and destabilizing ethylene biosynthesis related enzyme SADENOSYLMETHIONINE SYNTHETASE 1.

Copper is a CO₂ electroreduction catalyst consisting of at least two distinct active sites. Here, the authors report that the activities toward multicarbon products at these two sites can be independently tuned by modifying polyvinylpyridine to form distinct microenvironments.

Cation effects have been rigorously studied in electrochemical charge transfer, but their role in mass transport remains unexplored. Now, it has been shown that the structural entropy of cation hydration quantitatively explains how cations regulate reactant diffusion during the chlorine evolution reaction.

A ductile inorganic-rich solid–electrolyte interphase that retains its structural integrity and allows easy ion diffusion enables a long cycle life under practical conditions for lithium metal batteries.

Here, in a large-scale clinical trial, the authors associate gut microbiota composition and metabolic status with effectiveness of dietary fiber intervention in prediabetes, and provide a clinically applicable model to guide microbiome-targeted personalized medicine.

He, Wang, Shen, Dong and colleagues find that unsaturated fatty acids enriched in a black rice diet inhibit amyloid pathology, rescue cognition and restore physiological lifespan in mouse models of Alzheimer’s disease via allosteric activation of GPR120.

The electrochemical production of ethylene oxide from CO₂ is an attractive yet challenging process. Now, a BaO_x/IrO₂ catalyst for ethylene oxidation is reported and applied in an O₂-redox-mediated paired system for complete CO₂ to ethylene oxide production.

Uneven zinc growth limits the reversibility of zinc metal batteries. Here, authors use in situ X-ray computed tomography and fluid dynamics simulations to reveal how synthetic clay coating suppresses chaotic ion flow, enabling uniform zinc growth and stable cycling in a large-scale pouch cell.

This work demonstrates that stress-coupled atomic ordering at nanoscale Mn–Al–B interfaces will convert brittle boundaries into energy-absorbing zones, explaining the unusual coexistence of high strength, ductility, and low thermal expansion in magnesium alloys.

The introduction of ethylenediammonium diiodide reduces defects but also leads to severe hysteresis caused by excessive mobilized ions. Here, authors employ hydrazine monohydrochloride as a bulk passivator to mitigate such hysteresis, achieving maximum efficiency of 28.55% for tandem solar cells.

The industrial viability of alcohol electrooxidation is hindered due to low reaction rates. Here, the authors report a synergistic approach that integrating an active electrode (Ni_0.67V_0.33-layered double hydroxide) and aminoxyl radical to enhance the oxidation of alcohols at high current densities.

Limitations in proton transport within electrode materials diminish the proton storage capacity in aqueous zinc-organic batteries. Here, authors report an organic small molecule composite electrode enabling superharmonic fast proton motion via a crosslinked short hydrogen bond network, resulting in an electrode energy density up to 400 Wh kg⁻¹.

Solar-driven carbon dioxide reduction has witnessed a renaissance in the past decades, but the system suffers from low reaction rates. Here the authors develop a copper/tin-oxide electrocatalyst, achieving a new benchmark solar-to-CO energy conversion efficiency in a flow electrolyzer.

Electrochemical conversion of carbon dioxide to methane can store intermittent renewable electricity in a staple of global energy. Here, the authors develop a moderator strategy to maintain the catalyst in a low coordination state, thereby enabling stable and selective electrochemical methanation.

Solid polymer electrolytes suffer from limited ionic conductivity and poor interfacial stability for lithium batteries. Here, authors propose a fluorinated ether diluent to reduce the dipole-dipole interaction of ionic solvate with the polymer matrix and induce the formation of aggregates.

A large range of inert and non-defective sites in catalysts is a primary factor impeding catalyst activity in acidic CO₂ electroreduction. Here, the authors achieve high HCOOH selectivity and activity in acidic electrolyte by introducing tensile strain to activate inert sites.

Single-atom catalysts for sodium-sulfur batteries typically use d-block transition metal centers to accelerate polysulfide conversion, while s-block metals are generally considered inactive. Here, authors design a calcium-based single-atom catalyst for sodium-sulfur batteries.

The use of aqueous Zn-ion batteries is hindered by parasitic reactions, dendrite formation, and low Coulombic efficiency of Zn metal electrode. Here, authors regulate the electrolyte ions diffusion via ion-separation accelerating channel through self-assembly of poly(allylamine hydrochloride) and poly(acrylic acid).

Electrocatalytic reduction of CO₂ over copper can be made highly selective by ‘tuning’ the copper surface with adsorbed organic molecules to stabilize intermediates for carbon-based fuels such as ethylene

The production of higher alcohols is very valuable because of their high volumetric energy density. Now, Sargent, Sinton and co-workers report the design of copper nanoparticles with tailored nanocavities that promote n-propanol formation by the coupling of C2 and C1 intermediates inside the cavity.

All-solid-state batteries are potentially superior to Li-ion batteries, but to maximize performance, the solid electrolyte needs to be compatible with high-performance anodes. Halide solid electrolytes are shown to possess dynamic stability that extends beyond the electrochemical stability window, allowing improved full-cell performance.

Aqueous electroconversion of biomass derivatives to polymer precursors has been demonstrated at the laboratory scale with low yield. Here a solid polymer electrolyte reactor is engineered to limit side reactions, yielding a high rate and and a high product concentration in a 4.3-kW pilot-scale platform.

The introduction of sodium heparin passivates interface defects and enhances bonding between the electron transport layer and the perovskite layer in perovskite solar cells. The best-performing devices exhibit a certified PCE of 26.54% and maintain almost 95% of their initial performance after 1,800 h of maximum power point tracking.

Acidic conditions present a solution to carbonate formation in CO₂ electrolysis but create a selectivity issue through competing H₂ evolution. Here, theoretical methods are used to optimize acidity and select Pd–Cu as a selective electrocatalyst for acidic CO₂ reduction with negligible carbonate crossover and high single-pass carbon efficiency.

Authors present a method for providing fast and robust drift correction in single molecule localization microscopy, by pairing the nearest molecules in data segments and calculating their displacements within a small search radius.

This study reports that wild boars are a node animal in a virus circulation network connecting different animal taxa. Wild boar viruses not only pose threats to the pig industry but also challenge wildlife conservation and public health.

Water dissociation has proven power in tuning the behaviors of electrochemical CO₂ reduction. Here, the authors report the spontaneous water dissociation capability of the intermetallic electride LaCu_0.67Si_1.33 material that enables high rate electrosynthesis of methane from CO₂.

Liquid metals are widely used in flexible electronics and soft robotics applications, but their adhesion to underlying solid substrates is unwanted. Dai et al. show that liquid metal droplets can overcome adhesion forces and bounce off from the surface covered with a water film with sufficient thickness.

Acidic CO₂ electroreduction suffers poor selectivity for multi-carbon products. Here, the authors report that lengthening the 2-position substituents of benzimidazole-based copper coordination polymer precatalysts retards H⁺ diffusion, reduces Cu-Cu coordination numbers, and promotes C-C coupling.

To improve the tolerance of perovskite solar cells against high temperatures and temperature variations, Dong et al. covalently cross-link two molecules in the charge transport layer to strengthen adhesion with the perovskite layer.

Generating high-energy fuels from sunlight, water, and CO₂ using synthetic materials requires, among many things, the careful separation of reduced and oxidized products. Here, authors employ a zinc-based redox pair to spatially and temporally separate light-driven water oxidation and CO₂ reduction.

The black phase formamidinium lead iodide perovskite (α-FAPbI3) undergoes an undesired transformation to a non-perovskite δ-phase, rendering it inactive. Here authors show the significant role of inherent iodine defects in accelerating phase transition kinetics and exacerbating α-FAPbI3 instability.

Aqueous Zn-ion batteries are promising devices but their energy storage mechanism remains elusive. Now it is shown that these involve a catalytic mechanism based on water dissociation.

Electroreduction uses renewable energy to upgrade carbon dioxide to value-added chemicals and fuels. Here, the authors design a suite of ligand-stabilized metal oxide clusters to modulate the reduction pathways on a copper catalyst, enabling record activity for CO₂-to-methane conversion.

A variational-autoencoder-based diffusion architecture that enables topological controls on the diffusion-based protein structure generation is proposed. As a result, novel folds of mainly beta proteins can be designed with experimental validation.

The integration of colloidal nanoparticles into microdevices is essential for several advanced technologies. Here, the authors have developed a scalable method of UV-triggered surface charge modulation for the rapid surface patterning with semiconductor nanoparticles.

The authors introduce deep learning-optimized diffractive waveguides enabling various capabilities such as spatial and spectral mode filtering, mode splitting, and mode-specific polarization control, presenting their versatility and scalability.

Linear scaling relationships often hinder the optimization of heterogeneous catalysts. Now, an intermediate spillover strategy is put forward by designing bi-component catalysts, thereby decoupling elementary electron-transfer steps and circumventing linear scaling relationships.

In the electrified conversion of CO2 to multicarbon products, CO2 crossover to the O2-rich anodic stream adds a further, energy-intensive, chemical separation step. Here, the authors demonstrate a strategy that eliminates the separation requirement.

Glioblastoma (GBM) treatment faces challenges due to drug resistance. Here, the authors show that lysine-arginine balance supports lysosomes mediated tolerance to temozolomide and lysine restriction mimetic increases anticancer therapies in GBM preclinical models.

The electroreduction of CO₂ offers a promising approach to produce carbon-neutral methane using renewable electricity. This study shows that the introduction of Au in Cu enables selective methane production from CO₂ by regulating *CO availability.

Electrocatalytic reduction of CO₂ to multicarbon products is useful for producing high-value chemicals and fuels. Here the authors present a strategy that is based on the in situ electrodeposition of copper under CO₂ reduction conditions that preferentially expose and maintain Cu(100) facets, which favour the formation of C₂₊ products.