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Showing 1–50 of 64 results

Advanced filters: Author: Yuki Matsui Clear advanced filters

Antarctic ice-shelf collapse in Holocene driven by meltwater release feedbacks

Early Holocene retreat of an ice shelf in East Antarctica was linked to ocean-driven forcing enhanced by ice-sheet meltwater from adjoining regions, as unveiled through the integration of proxy records with ocean and climate modelling.

Yusuke Suganuma
Takuya Itaki
Hideki Miura
ResearchOpen Access07 Nov 2025
Nature Geoscience

Volume: 18, P: 1216-1223
Author Correction: Antarctic ice-shelf collapse in Holocene driven by meltwater release feedbacks

Yusuke Suganuma
Takuya Itaki
Hideki Miura
Amendments and CorrectionsOpen Access18 Nov 2025
Nature Geoscience

Volume: 18, P: 1319
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Outcomes of sequential therapy for advanced upper tract urothelial cancer and bladder cancer

Manato Kanesaka
Tomokazu Sazuka
Tomohiko Ichikawa
ResearchOpen Access25 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Three stepwise pH progressions in stratum corneum for homeostatic maintenance of the skin

Previous studies of the skin have suggested a neutral-to-acidic pH gradient in the outermost layer. Here, the authors perform quantitative intravital pH imaging of the stratum corneum, the outermost epidermal layer, and demonstrate three distinct pH zones - rather than a gradient - with different biological functions.

Keitaro Fukuda
Yoshihiro Ito
Masayuki Amagai
ResearchOpen Access15 May 2024
Nature Communications

Volume: 15, P: 1-19
The structure and function of the ghrelin receptor coding for drug actions

This study reveals how anamorelin, a superagonist targeting the ghrelin receptor, works compared to other drugs. Structural insights into ligand binding and genetic variations offer a framework for personalized therapies

Yuki Shiimura
Dohyun Im
Ikuo Masuho
Research20 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 531-542
In silico analysis of sodium ion permeation mechanisms in transient receptor potential vanilloid 1

Yuki Nagasato
Keisuke Sanematsu
Noriatsu Shigemura
ResearchOpen Access29 Dec 2025
Scientific Reports

Volume: 15, P: 1-9
Prognostic factors in patients with interstitial lung disease treated with nintedanib: a multicenter retrospective study in Japan

Shiho Goda
Tadaaki Yamada
Koichi Takayama
ResearchOpen Access27 Dec 2025
Scientific Reports

Volume: 16, P: 1-11
Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing

The ability of bone marrow to recruit transplanted hematopoietic stem cells decreases with age. Here, the authors demonstrate that this decline is caused by reduced sinusoidal shear stress due to increased non-neuronal acetylcholine degradation.

Takayuki Morikawa
Shinya Fujita
Keiyo Takubo
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Influence of differences in bone morphology on the distribution patterns of subchondral bone density across the trapeziometacarpal joint

Yukinori Tsukuda
Yuichiro Matsui
Norimasa Iwasaki
ResearchOpen Access20 Jul 2022
Scientific Reports

Volume: 12, P: 1-8
Regioselective stilbene O-methylations in Saccharinae grasses

O-methylated stilbenes are promising nutraceutical candidates. Here, the authors reveal that sorghum and wild sugarcane accumulate different types of O-methylated stilbenes due to major differences in catalytic regioselectivities of O-methyltransferases.

Andy C. W. Lui
Kah Chee Pow
Clive Lo
ResearchOpen Access12 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Extended magenta aurora as revealed by citizen science

Ryuho Kataoka
Sachin Alexander Reddy
Yuki Nakamura
ResearchOpen Access28 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Isolation of an archaeon at the prokaryote–eukaryote interface

Isolation and characterization of an archaeon that is most closely related to eukaryotes reveals insights into how eukaryotes may have evolved from prokaryotes.

Hiroyuki Imachi
Masaru K. Nobu
Ken Takai
Research15 Jan 2020
Nature

Volume: 577, P: 519-525
Two-step regulation of centromere distribution by condensin II and the nuclear envelope proteins

In Arabidopsis cells undergoing mitosis, centromere distribution is shown to be regulated by two steps: scattering in M-phase and stabilization in interphase. This may affect the maintenance of genome integrity rather than gene regulation.

Takuya Sakamoto
Yuki Sakamoto
Sachihiro Matsunaga
Research01 Aug 2022
Nature Plants

Volume: 8, P: 940-953
Novel organoid-based exploration reveals the role of LMTK3/FADS2 signaling in metastatic breast cancer progression in felines and humans

Haru Yamamoto
Mohamed Elbadawy
Kazuaki Sasaki
ResearchOpen Access22 Nov 2025
Scientific Reports

Volume: 15, P: 1-24
Landscape of bla_NDM genes in Enterobacteriaceae

Yuta Kikuchi
Hidehito Matsui
Akio Abe
Research19 Aug 2022
The Journal of Antibiotics

Volume: 75, P: 559-566
Implications of navigation system use for glenoid component placement in reverse shoulder arthroplasty

Hiroaki Kida
Atsushi Urita
Norimasa Iwasaki
ResearchOpen Access07 Dec 2022
Scientific Reports

Volume: 12, P: 1-9
Inhaled turmerones can be incorporated in the organs via pathways different from oral administration and can affect weight-gain of mice

Yuki Takemoto
Chihiro Kishi
Nobuhiro Zaima
ResearchOpen Access30 Jun 2022
Scientific Reports

Volume: 12, P: 1-8
Long-term incidence of posterior capsular opacification in patients with non-infectious uveitis

Yuki Kitaguchi-Iwakiri
Koju Kamoi
Kyoko Ohno-Matsui
ResearchOpen Access11 Mar 2022
Scientific Reports

Volume: 12, P: 1-7
Changes in elbow joint contact area in symptomatic valgus instability of the elbow in baseball players

Kyosuke Numaguchi
Daisuke Momma
Norimasa Iwasaki
ResearchOpen Access05 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
A Printed Organic Circuit System for Wearable Amperometric Electrochemical Sensors

Rei Shiwaku
Hiroyuki Matsui
Shizuo Tokito
ResearchOpen Access23 Apr 2018
Scientific Reports

Volume: 8, P: 1-8
Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021

Takahito Ouchi
Yoshihiro Watanabe
Satoshi Ōmura
Research06 Mar 2020
The Journal of Antibiotics

Volume: 73, P: 365-371
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression

The authors investigate the in vivo function of microRNA-124a by specifically disrupting Rncr3, the dominant source of miR-124a in mice. Their results suggest that miR-124a is important for maturation and survival of dentate gyrus neurons and retinal cones and acts by repressing Lhx2 translation.

Rikako Sanuki
Akishi Onishi
Takahisa Furukawa
Research21 Aug 2011
Nature Neuroscience

Volume: 14, P: 1125-1134
A Printed Organic Amplification System for Wearable Potentiometric Electrochemical Sensors

Rei Shiwaku
Hiroyuki Matsui
Shizuo Tokito
ResearchOpen Access02 Mar 2018
Scientific Reports

Volume: 8, P: 1-8
Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia

Environmental cues instruct cell fate during hematopoiesis. Igarashi and colleagues show that the transcription factors Bach1 and Bach2 promote erythropoiesis and suppress myelopoiesis. Infection and inflammatory signals suppress Bach expression, which results in anemia.

Hiroki Kato
Ari Itoh-Nakadai
Kazuhiko Igarashi
Research24 Sept 2018
Nature Immunology

Volume: 19, P: 1059-1070
Delivery of a BET protein degrader via a CEACAM6-targeted antibody–drug conjugate inhibits tumour growth in pancreatic cancer models

Therapeutic options for pancreatic ductal adenocarcinoma (PDAC) are limited. Here the authors report the characterization of a CEACAM6-targeting antibody drug conjugate loaded with a BET protein degrader, showing antitumour activity in PDAC preclinical models.

Youya Nakazawa
Masayuki Miyano
Akihito Machinaga
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-17
The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program

The role of the repressors Bach1 and Bach2 in early B cell development is unclear. Igarashi and colleagues have now found these Bach factors directly repress various myeloid genes in common lymphoid progenitors to restrict a B cell lineage fate.

Ari Itoh-Nakadai
Reina Hikota
Kazuhiko Igarashi
Research26 Oct 2014
Nature Immunology

Volume: 15, P: 1171-1180
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Transcription factor Spi-B–dependent and –independent pathways for the development of Peyer’s patch M cells

S Sato
S Kaneto
H Kiyono
Research05 Dec 2012
Mucosal Immunology

Volume: 6, P: 838-846
Tuning of structural, optical band gap, and electrical properties of room-temperature-grown epitaxial thin films through the Fe₂O₃:NiO ratio

Okkyun Seo
Akhil Tayal
Mamoru Yoshimoto
ResearchOpen Access13 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Soichi Ogishima
Satoshi Nagaie
Masayuki Yamamoto
ResearchOpen Access10 Dec 2021
Human Genome Variation

Volume: 8, P: 1-8
Discontinuing renin-angiotensin system inhibitors after incident hyperkalemia and clinical outcomes: target trial emulation

Nobuhiro Hashimoto
Yusuke Sakaguchi
Yoshitaka Isaka
ResearchOpen Access14 May 2025
Hypertension Research

Volume: 48, P: 2034-2044
Lyotropic ordering for high proton conductivity in sulfonated semialiphatic polyimide thin films

High-molecular-weight (HM_w) sulfonated polyimide thin films with a semialiphatic main chain exhibited an oriented lamellar structure and high proton conductivity (1.5 × 10^-1 S cm^-1) under humidified conditions. Low-molecular-weight (LM_w) sulfonated polyimide thin films with the same semialiphatic backbone exhibited a nonoriented lamellar structure and low proton conductivity (3.0 × 10^-2 S cm^-1) under humidified conditions. The results indicate that, in sulfonated polyimide thin films with semialiphatic main chain, the lamellar orientation greatly contributes to the high proton conductivity.

Kensaku Takakura
Yutaro Ono
Yuki Nagao
Research03 Aug 2018
Polymer Journal

Volume: 51, P: 31-39
Temporal and fertilizer-dependent dynamics of soil bacterial communities in buckwheat fields under long-term management

Susumu Morigasaki
Motomu Matsui
Naoki Takaya
ResearchOpen Access30 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition

Early developmental stress alters microglial function, linked to schizophrenia and autism. In a mouse model, inflammatory 2HIT stress increased cerebellar microglia and its turnover, causing Purkinje neuron loss and cerebellar dysfunction, which was improved by microglia replacement.

Momoka Hikosaka
Md Sorwer Alam Parvez
Gen Ohtsuki
ResearchOpen Access03 Mar 2025
Communications Biology

Volume: 8, P: 1-26
Preventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice

Xixi Li
Yuka Ichiba
Toshiro Matsui
ResearchOpen Access29 Dec 2024
npj Science of Food

Volume: 8, P: 1-8
Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle

Reiko Nakao
Weilin Shen
Takeshi Nikawa
ResearchOpen Access09 Sept 2021
npj Science of Food

Volume: 5, P: 1-10
Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation

Shinji Fukaya
Yuki Matsui
Akihiro Ishizu
Research12 Nov 2012
Laboratory Investigation

Volume: 93, P: 72-80
Cultivable microbial community in 2-km-deep, 20-million-year-old subseafloor coalbeds through ~1000 days anaerobic bioreactor cultivation

Hiroyuki Imachi
Eiji Tasumi
Fumio Inagaki
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-16
Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt–Jakob disease

Katsuya Satoh
Minoru Tobiume
Testutaro Sata
Research09 Aug 2010
Laboratory Investigation

Volume: 90, P: 1637-1644
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Correction: Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer

Taichi Kuwahara
Shoichi Hazama
Hiroaki Nagano
Amendments and CorrectionsOpen Access17 Oct 2019
British Journal of Cancer

Volume: 121, P: 983-984
A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration

Lihong Cheng
Mitsuru Tanaka
Toshiro Matsui
ResearchOpen Access07 Oct 2023
Scientific Reports

Volume: 13, P: 1-11
Possible contribution of phosphate to the pathogenesis of chronic kidney disease in dolphins

Nourin Jahan
Hiroyuki Ohsaki
Akira Nishiyama
ResearchOpen Access29 Mar 2023
Scientific Reports

Volume: 13, P: 1-13

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