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Authors develop MuPPE, which enables integrated proteome, phosphoproteome, and glycoproteome profiling from a single sample, providing deeper biological insights into aging and drug-response mechanisms.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Using an accurate genomic biomarker signature as a means to identify hypervirulent Klebsiella pneumoniae (hvKp-p), authors perform a longitudinal cohort study to provide insight into the clinical and genomic characteristics of hvKp-p.

Insufficient electron injection remains a limiting factor for the performance of stretchable organic light-emitting diodes. Here designs for both electron transport layer and cathode in stretchable organic light-emitting diodes are reported to achieve efficient electron injection.

While Prussian blue (PB) nanozymes are typically employed as antioxidants, their reactive oxygen species-generating capability remains unexplored. Here, the authors predict by molecular dynamics and identify explicit hydroxyl radical generation in highly crystalline cesium-doped PBs.

We study the impact of interactions on the population distribution in a topological trimer array of ultracold atoms, and observe the formation of nonlinear edge states.

The authors report experimental evidence of phonon Stark effect in 2H-MoS₂ bilayers. A Stark phonon appears as the interlayer excitons are tuned to resonate with the LA phonon emission line, and shows a linear energy shift upon application of an out-of-plane electric field.

Offshore wind-powered green methanol could achieve cost parity with conventional marine fuels by 2030−2035 under EU regulations, enabling sustainable shipping through scalable technology and policy incentives.

Glucocorticoids, potent anti-inflammatory drugs, can cause or exacerbate obesity, yet the underlying molecular mechanisms remain largely unknown. Here, the authors show KLF9 in macrophages integrates the beneficial anti-inflammatory and adverse metabolic effects of glucocorticoids.

Propagators of single photons based on directly measuring quantum wave functions are experimentally observed. Classical trajectories that satisfy the principle of least action are successfully extracted in the case of free space and harmonic potential.

Although surface-bound molecular catalysts offer well-defined active sites on heterogeneous supports, it is challenging to identify key radical intermediates in the reaction mechanism. Now, a characterization method has been developed that combines film electrochemistry and EPR spectroscopy to track radical intermediates in real time, exemplified by alcohol oxidation with a surface-immobilized nitroxide.

Distinguishing proteoforms and post-translational modifications has remained a challenge. Here the authors explore single-molecule fluorescence resonance energy transfer to probe amino acids via DNA exchange and map the location of individual amino acids and post-translational modifications within single full-length protein molecules.

Diverse cellular E3 ubiquitin ligase–degron pairs are used to generate live attenuated influenza vaccines. Attenuation and humoral, mucosal and cellular immune responses were characterized in mouse and ferret models.

Congenital heart disease is life threatening, and its screening is complex and costly. Here, authors use AI to detect the disease based on pediatric electrocardiogram, suggesting superior performance over cardiologists.

A quantum memory for single-photon polarization qubits with an efficiency of >85% and a fidelity of >99% is demonstrated. It is achieved by suppressing the noise and by controlling the spectral–temporal states of single photons in laser-cooled Rb atoms.

Cui, Guo, Liu et al. identify a bacterial species, Peptostreptococcus anaerobius, in the gut that produces a tryptophan metabolite and engages intracellular pathways to modulate ferroptosis-suppressor protein 1 activity, thereby suppressing ferroptosis and promoting colorectal cancer development.

We report on a method for inducing uncontaminated and precise inhomogeneous strain in nanoscale silicon ribbons and its use for determining physical effects in these strained materials, in particular, an increase in the range and control of thermal conductivity.

A non-volatile memory device that is based on an aluminium scandium nitride (Al_0.68Sc_0.32N) ferroelectric diode can operate at temperatures of up to 600 °C.

Synthetic gauge field in ultracold atoms provides a controllable platform for the study of quantum many-body physics. Here the authors demonstrate frustrated chiral dynamics in synthetic triangular flux ladder under strong interaction using ultracold Cs atoms.

Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.

Active systems made of self-propelled units are widespread in nature, and Active Brownian particles (ABPs) are one of the simplest such system The authors theoretically and numerically investigate the collective assembly of ABPs finding a new re-entrant phase that enables motility-induced phase separation, which is dependent solely on activity.

Only a few relaxors can be grown into crystals, which show high piezoelectricity, but their operable temperature range is limited by the low phase transition temperature. Here, the authors develop an approach to fabricate textured relaxor ceramics with elevated phase transition temperatures.

Molecular sieving separates larger from smaller molecules, but all molecules smaller than the pore adsorb, hindering selectivity. Here, a MOF is reported with both molecular sieving and gate-opening, separating intermediate-sized molecules from larger and smaller analogues.

A two-leg ladder with tunable gauge fields is achieved by one-dimensional synthetic momentum-state lattice of a noninteracting Bose gas.

Coevolving millions of cold dark matter particles and neutrinos within one N-body simulation, TianNu, shows that regions of similar dark matter density can have different neutrino densities. These density variations may have an effect on the cosmic structure.

The identification and structural analysis of HLA-E-VL9-targeting antibodies that block a natural killer (NK) cell receptor pathway and regulate NK function in vitro.

Amide-bearing organic compounds are important building blocks in organic synthesis, however, the ambident reactivities of the nitrogen and oxygen atoms in the amide moiety requires catalysts and reagents that are able to control the reaction selectivity. Here, hypervalent iodine reagents are shown to mediate the intramolecular cycloisomerization of O-alkenylbenzamides to selectively generate isoquinolinone and iminoisocoumarin derivatives.

Hypervalent iodine(III) reagents show promising properties in organic synthesis, however, the application of nitrooxyl (O2NO)-containing I(III) reagents remains underexplored. Here, the authors report the synthesis of a benziodazole-type O2NO-I(III) reagent, which can be applied to the synthesis of furazan heterocycles as a nitrating agent, by reaction with β-monosubstituted enamines via a copper-catalyzed radical nitration/cyclization/dehydration cascade.