Reflex circuits are specifically formed between sensory and motor neurons based on the class of sensory cell and the muscle type innervated by the motor neuron. Here, this fine synaptic specificity is found to be mediated by selective expression of the class 3 semaphorin Sema3e and its high-affinity receptor plexin D1 (Plxnd1) by specific motor and sensory neuron populations, respectively.
- Eline Pecho-Vrieseling
- Markus Sigrist
- Silvia Arber
