Nature Search

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine packaging and leading to increased neurotransmitter release.

Zachary Freyberg
Mark S. Sonders
Jonathan A. Javitch
ResearchOpen Access16 Feb 2016
Nature Communications

Volume: 7, P: 1-15
Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors

Ventral striatal dopamine D3 and D1 receptors regulate motivation and reinforcement, respectively, through dissociable physiological actions.

Juan Enriquez-Traba
Miguel Arenivar
Hugo A. Tejeda
Research09 Dec 2024
Nature Neuroscience

Volume: 28, P: 105-121
Brain-wide mapping reveals temporal and sexually dimorphic opioid actions

This study introduces a semi-automated, scalable whole-brain mapping workflow that enables unbiased comparisons across cohorts, revealing widespread temporally and sexually distinct regional activation patterns after acute morphine exposure in mice.

Iaroslavna Vasylieva
Reese Smith
Alan M. Watson
ResearchOpen Access20 Feb 2026
Communications Biology

Volume: 9, P: 1-15
Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder

Dysfunction in dorsal striatum, a brain region important for reward and habits, is linked to opioid use disorder (OUD). Here, authors delineate diverse cell populations in human dorsal striatum, revealing altered inflammatory and DNA damage signaling in OUD.

BaDoi N. Phan
Madelyn H. Ray
Ryan W. Logan
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-19
New roles for dopamine D₂ and D₃ receptors in pancreatic beta cell insulin secretion

Zachary J. Farino
Travis J. Morgenstern
Zachary Freyberg
Research09 Jan 2019
Molecular Psychiatry

Volume: 25, P: 2070-2085
Dopamine D₂ receptor modulates Wnt expression and control of cell proliferation

Fei Han
Prasad Konkalmatt
Ines Armando
ResearchOpen Access14 Nov 2019
Scientific Reports

Volume: 9, P: 1-21
Psychiatric factors predict type 2 diabetes mellitus in US Veterans

Lora Lee Pless
Chantele Mitchell-Miland
Gretchen L. Haas
ResearchOpen Access17 Apr 2025
Schizophrenia

Volume: 11, P: 1-8
Brain and body energy metabolism and potential for treatment of psychiatric disorders

This Perspective highlights the important role of energy metabolism in psychiatric disorders and sets the groundwork for future studies in the emerging field of metabolic psychiatry.

Ana C. Andreazza
L. Felipe Barros
Corey Weistuch
Reviews25 Jun 2025
Nature Mental Health

Volume: 3, P: 763-771
Glucose dysregulation in antipsychotic-naive first-episode psychosis: in silico exploration of gene expression signatures

Jiwon Lee
Xiangning Xue
Margaret K. Hahn
ResearchOpen Access10 Jan 2024
Translational Psychiatry

Volume: 14, P: 1-12
Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain

Silas A. Buck
Samuel J. Mabry
Zachary Freyberg
Research29 Jan 2025
Molecular Psychiatry

Volume: 30, P: 3039-3054
Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Despoina Aslanoglou
Suzanne Bertera
Zachary Freyberg
ResearchOpen Access16 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-18
Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens

Stephanie Puig
Xiangning Xue
Ryan W. Logan
ResearchOpen Access06 Sept 2023
Molecular Psychiatry

Volume: 28, P: 4777-4792
Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving

Yi He
Junshi Wang
Yan Dong
Research11 Apr 2023
Neuropsychopharmacology

Volume: 48, P: 1318-1327
Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia

Silas A. Buck
M. Quincy Erickson-Oberg
Zachary Freyberg
Reviews10 Jun 2022
Molecular Psychiatry

Volume: 27, P: 3583-3591
Dopamine D₂ receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances

Zachary Freyberg
Michael J. McCarthy
ReviewsOpen Access10 Apr 2017
npj Schizophrenia

Volume: 3, P: 1-8

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Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors

Brain-wide mapping reveals temporal and sexually dimorphic opioid actions

Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder

New roles for dopamine D₂ and D₃ receptors in pancreatic beta cell insulin secretion

Dopamine D₂ receptor modulates Wnt expression and control of cell proliferation

Psychiatric factors predict type 2 diabetes mellitus in US Veterans

Brain and body energy metabolism and potential for treatment of psychiatric disorders

Glucose dysregulation in antipsychotic-naive first-episode psychosis: in silico exploration of gene expression signatures

Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain

Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens

Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving

Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia

Dopamine D₂ receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances

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