Dysregulation in the proteasome pathway contributes to the pathogenesis of head and neck squamous cell carcinoma (HNSCC). Here the authors identify that Casein kinase 2 (CK2) mediates phosphorylation of Proteasome activator 28 subunit gamma (PA28γ), which promotes tumor formation and progression in HNSCC mouse models.
- Silu Sun
- Bing Zhong
- Qianming Chen
