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The development of chemoenzymatic dynamic kinetic resolution has long been constrained by principal limitations, which need precise synchronization of racemization and resolution steps for rate matching. Here, the authors introduce a membrane-modulated strategy that circumvents the mandatory requirement for strict rate matching.

The interface between perovskite and tin dioxide in perovskite solar cells suffers from interfacial defects and energy level mismatch that limit efficiency. Zhang et al. add a polymerized dimethyldiallylammonium chloride interlayer to passivate defects, tune band bending, and enhance charge extraction.

This study reveals that groundwater depletion releases substantial CO₂ worldwide, identifying a previously overlooked carbon source that should be considered in global carbon management.

The authors report ambient-pressure, polarization-resolved electronic Raman scattering measurements on single crystals of nickelate La₃Ni₂O₇, which becomes superconducting under pressure. Quantitative analysis reveals momentum-selective spin density wave (SDW) gap amplitudes, indicating an unconventional SDW driven by anisotropic electronic correlations.

This study achieves ultrafast all-electrical perpendicular magnetization switching with a pulse width of 16 ps and an energy consumption of 41 fJ/bit in a CoTb/Ti/CoFeB/MgO heterostructure, enabled by combining the in-plane and out-of-plane spin current.

Tinengotinib is a spectrum-selective multi-kinase inhibitor targeting several oncogenic and immunoregulatory pathways, including FGFR1–3, JAK1/2, VEGFRs, and Aurora A/B kinases. Here the authors report the results of a phase Ib/II trial of tinengotinib as monotherapy or combined with anti-PDL1 atezolizumab in patients with advanced solid tumors.

SUCCEED is a supervised multi-task DNA foundation model pretrained on 6,389 ENCODE tracks. It integrates CNN and Transformer architectures to model local motifs and long-range dependencies, enabling prediction of genomic regulatory features across tasks and cell types.

Hepatitis C virus remains a health burden due to the lack of an effective vaccine, hindered by difficulties in replicating the native E1E2 antigen structure. Here, the authors engineer a stabilized E1E2 heterodimer using cryo-EM-guided modifications, enhancing immunogenicity and paving the way for future HCV vaccine development.

Using time-resolved cryo-EM, this study captures fibrillar collagen assembly as it matures from a metastable to a stable state, shedding light on tissue maintenance and disease-linked defects.

Telomeric systems are conserved across eukaryotes and may have originated over 1 billion years ago. Here the authors replaced yeast’s telomeres with a bacterial virus system, resulting in a stable functional assembly of DNA molecules up to 2.77 Mb, offering insights into the possible origins of telomeres.

Early detection of nasopharyngeal carcinoma through Epstein–Barr virus serology is hindered by a low positive predictive value. Here this group introduces a hierarchical dynamic model for stratification refinement within serologically defined risk individuals thereby yielding cost savings for current serological screening strategy.

Addressing the permeability-selectivity trade-off in helium recovery, the authors engineered MOF gel-crosslinked membranes. Covalent interfacial bonding enables defect-free, ultra-high MOF loadings, yielding exceptional separation performance that pushes beyond conventional upper bounds.

ZAT-DNA encodes data in A/Z base patterns that PCR erases, ensuring molecular non-replicability. It enables secure 32/64-bit key storage and nanopore retrieval, blocks copying, and protects NFTs. The Babel-DNA hybrid allows selective access to multiple encrypted datasets from a single DNA pool using unique ZAT-DNA keys.

Photo-cross-linking is widely used in protein science, but site-specific identification remains elusive. Here, the authors show that alkyl diazirine cross-links are inherently MS-cleavable and develop an analytical framework that integrates seamlessly with existing search platforms.

The authors revealed that defective sulfation of a cholesterol-derived metabolite drives harmful lipid buildup in cartilage cells, while the sulfated form protects against osteoarthritis.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Cuffless hemodynamic monitoring via wearables holds great potential to detect, monitor, and treat patients with cardiovascular disease. Here, the authors establish the mechanistic link between fluid and electrical quantities and develop an algorithm to measure cuffless blood pressure and velocity with a smartwatch.

Most atmospheric water harvesters suffer from slow sorption and intermittent solar-driven desorption. Here, the authors develop a hybrid wood composite with a phase change material that stores solar heat. It rapidly captures water across a wide humidity range and releases it continuously, even in darkness, achieving a daily yield of 0.96–1.72 L kg⁻¹.

All-inorganic perovskite solar cells promise strong stability but still suffer from moisture-driven surface damage and limited efficiency. Zhang et al. form a one-dimensional/three-dimensional interface using a tailored salt to stabilize the material and boost performance.

Making catalyst surfaces both active and durable is a key challenge for cleaner chemical reactions. This study uses sunlight to grow tiny platinum sites on titanium oxide that adapt during use and greatly improve low-temperature carbon monoxide oxidation.

The authors integrate morphotropic phase boundary engineering with high-entropy design in a quinary perovskite ceramic, which yields a piezoelectric coefficient of 580 pC/N and exceptional thermal stability, with performance retained up to 285 °C.

Spindle neurons in the human cortex are morphologically distinct. Here, authors show that they also possess distinctive electrophysiological and transcriptomic features, establishing them as a functionally specialized cell type in the human brain.

The malto-oligosaccharides (MOS) serve as essential primers for starch synthesis in higher plants. Authors demonstrate that two enzymes, PHS1 and DPE1, form a binary complex and coordinately promote MOS synthesis as a key initial step in starch biosynthesis.

The authors introduce controlled compositional heterogeneity to broaden polarization vector distributions while preserving the antiferroelectric modulation in PbZrO₃-based ceramics. They reduce polarization hysteresis while maintaining high polarization strength.

Neogene lithium isotope records from the Tibetan Plateau suggest that silicate weathering in mountain ranges may not persistently contribute sufficient lithium into the ocean to regulate seawater lithium isotope evolution

Typically, metal additive manufacturing requires costly high vacuum/ultra-pure inert atmospheres to avoid material embrittlement. This alloy design simultaneously boosts a medium-entropy alloy’s strength and ductility through trace oxygen and nitrogen in-situ alloying, eliminating high-purity gas needs.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Li extraction from seawater is promising but challenged by low concentration and high Mg/Li ratio. Here, the authors report an integrated electrochemical system coupling Li extraction with in situ energy storage and H₂ production, upgrading seawater to a Li-rich solution with low energy consumption.

Alternative transcription start sites generate transcript diversity but are difficult to detect due to RNA degradation in 5’ scRNA-seq. Here, the authors present scATS, which corrects degradation to quantify TSS usage, improve cell clustering, and identify lung cancer-promoting TSS isoforms.

Reversible-deactivation radical polymerisations are highly sensitive to oxygen and inhibitors, hindering their industrial application. Here, the authors report a heterogeneous phenanthroline-based conjugated hypercrosslinked polymer photocatalyst for photoinduced copper-catalysed atom transfer radical polymerisations, achieving high oxygen and inhibitor tolerance.

Self-healing materials typically suffer from poor mechanical properties due to the inherent trade-off between mechanical robustness and self-healing capability. Here the authors report a composite featuring an aligned array of hydroxyapatite nanowires interwoven with dynamic borate bond networks by a bidirectional freeze-drying method.

Valine metabolism disruption is linked to heart disease, but the mechanisms are unclear. Here, the authors show that ACAD8 deficiency drives isobutyryl-CoA accumulation and histone isobutyrylation, increasing chromatin accessibility and gene expression to promote cardiac hypertrophy, while ACAD8 overexpression reverses these effects.

Low-dose IL-2 therapy has been evaluated for the treatment of numerous autoimmune conditions. This study reports the outcomes of a phase 2, randomised, placebo-controlled trial evaluating the efficacy and safety of low-dose IL-2 for the treatment of systemic lupus erythematosus (SLE).

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

The authors report an artificial plateau neuron with bistable, spike-malleable dynamics that generates programmable rhythmic bursts, enabling a quadruped robot to walk adaptively and energy-efficiently via distributed hardware control without centralized computation.

Molecular characteristics of amniote lineages can inform evolutionary inference. Here, the authors present a single-cell RNA-sequencing atlas of the chicken, which is applied to compare immune cells of chicken, turtle, duck and human, determining similarities and distinctions across amniote immune system evolution.

Inner ear diseases are difficult to treat due to anatomical constraints. Here, the authors present a dual-segment continuum robot integrating navigation, endoscopy, and a force-sensing microneedle for atraumatic transcanal access to the round window membrane.

Researchers have found that extreme hot-wet weather in 2024 triggered a spike in ecosystem respiration, mainly in tropical non-forests, significantly reducing the year’s land carbon sink and pushing the atmospheric CO2 growth rate to a record high.

High-performance perovskite tandem solar cells are limited by uneven, disordered self-assembled monolayer (SAM) acting as hole-selective layers. Luo et al. design a SAM that yields uniform, stable interfaces, reducing non-radiative losses and boosting efficiency and durability

Self-assembled monolayers struggle to uniformly coat textured surfaces, limiting high-efficiency perovskite and silicon tandem solar cells. Du et al. increase surface hydroxyl groups by incorporating carbon into polysilicon, enabling stable monolayer attachment and record device efficiency.

Most studies assessing food self-sufficiency look at calories and neglect nutrient gaps. Comparing food demand and potential food production under land and water constraints, this study quantifies 9 key nutrient gaps for each of African’s 54 countries.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

Rare cancers can be challenging to diagnose from imaging due to limited data and previous expert experience. Here, the authors develop the PathPT framework to improve subtyping and tumour localisation.

Here, the authors uncover a mechanism by which drug-target homologs mediate non-antibiotic drug effects on bacterial growth, and suggest a universal homology-based competition strategy to reverse MTX-induced microbiota dysbiosis.

Pre-existing hypoglycemia weakens the host’s interferon-based immune defense by downregulating the antiviral protein TRIM5 in the lung, thereby increasing the susceptibility to influenza infection.

Analyses of sequencing data from 75,602 children referred for genetic testing from 2016 to 2025 provide insights on the association between pathogenic germline variants and childhood cancer.

Here the authors present a single-bacterium metabolomics platform that enables sensitive metabolic profiling of individual bacteria, revealing metabolic heterogeneity in heteroresistant K. pneumoniae strains and providing insights into bacterial survival and resistance.

Concentration polarization limits cycling stability of cells at high currents. Here, authors propose a mechanical-electrochemical conversion strategy by constructing a piezo electrolyte that actively utilizes the unavoidable volume fluctuation of lithium metal to minimize concentration polarization.