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NK cell function in liver cancer has been shown and may influence the progression of liver cancer. Here the authors use mouse liver cancer models and spatial transcriptomics in an immune-humanized liver cancer mouse model to show that NK cells can influence the early progression of liver cancer by altering lipid metabolism and tumour stemness, subsequently demonstrating that inhibition of these pathways can enhance immune cell-mediated tumour control.

The first data of the Jiangmen Underground Neutrino Observatory deliver high-precision neutrino oscillation parameters, improving measurements and demonstrating readiness to determine neutrino mass ordering.

This study shows that the TaMPK3 signaling pathway regulates wheat resistance to Fusarium crown rot (FCR) and reveals TaMPK3-mediated synergistic damage from FCR and drought, thereby providing a mechanistic basis for drought-aggravated FCR severity.

Traditional strategies to address wear particle-induced osteolysis largely focus on reducing wear generation, rather than mitigating the immunostimulatory effects elicited by wear particles. Here, the authors report a proactive preventive approach to implant design that adopts CeO₂ nanozymes-incorporated liners to actively limit the harmful immune effects of particles.

Gastric signet ring cell carcinoma is marked by abnormal mucin accumulation, but its molecular drivers are incompletely understood. Here, authors show that loss of ARID1A promotes mucin overproduction and defective secretion through SCIN suppression and BRD9 activation, revealing a targetable vulnerability in this cancer.

Scalable perovskite solar cell production is limited by moisture sensitive interfacial layers. Li et al. develop a low hygroscopic solvent system enabling ambient blade coating of precursors, including self-assembled monolayers and passivation layers, yielding high device efficiency.

In this paper, a perovskite-based single-pixel imaging system is developed that simultaneously captures fluorescence and background images with perfect alignment, enabling real-time tumor localization and tracking in mice without complex registration algorithms.

Interleukin-1 receptor-associated kinase 2 (IRAK2) is essential for Myddosome complex formation downstream of most Toll-like receptors. Here, the authors show a loss-of-function copy number variant of IRAK2 associated with immunodeficiency, autoimmunity, and autoinflammation, which disrupts IRAK2 interaction with IRAK4 and further downstream Myddosome formation, accompanied by enhanced interferon responses.

Turning carbon dioxide into ethylene requires catalysts that control intermediate formation and coupling on copper surfaces. Here, the authors show that aluminum-doped copper tunes these intermediates through orbital interactions, enabling efficient ethylene production from dilute carbon dioxide.

Acoustic sensing devices are important to realize human‒machine interfaces. Here, the authors report the fabrication of freestanding reduced graphene oxide membranes with a diameter-to-thickness ratio of ~10⁶, leading to a static pressure responsivity of ~ 500 μm/Pa and high-performance microphone applications.

Zinc-based batteries offer safe energy storage but are limited by damaging dendrite growth. Here, authors report a zinc-specific nucleation model and a stability metric to design an advanced electrolyte that prevents dendrites, yielding highly stable, long-lasting batteries.

X-ray triggered molecular switches are promising for remote control through physical barriers, though it is challenging to reach the photostationary state for some radioswitches. Here the authors design a flexible radioswitching film using a triplet-triplet energy transfer system.

Obesity shows sexual dimorphism. Here, the authors identify the germ cell -specific gene C2orf74 as a driver of diet induced obesity via suppression of androgen signalling and subsequently white adipocyte browning in male but not in female mice.

The κ-opioid receptor (κOR) is a promising target for safer pain therapies. Here, authors present the cryo-EM structure of a salvinorin A-bound κOR dimer complexed with two Gi proteins, revealing a lipid-mediated interface and dimerization-enhanced Gi recruitment.

This study identifies excitation-mode adsorption on metallophthalocyanine/reduced graphene oxide composites. Strong interfacial interaction enables efficient UV-induced charge transfer, generating stable excited holes as new active adsorption sites.

This work proposes an MTJ-enhanced magnetoelectric spin-orbit (MESO) logic architecture for giant spin-orbit magnetic state readout. The device achieves a room-temperature output voltage up to 1.5 mV and instant and efficient data exchange between computing and memory units.

Formation of the Solar System’s comet reservoirs remain uncertain. Here, the authors show that AI-based analysis of comet activity reveals a far more populated Oort Cloud than previously thought.

The honeycomb antiferromagnet Na₃Ni₂BiO₆ has been shown to exhibit a one-third magnetization plateau. Here, the authors identify multiple quantum phases both inside and beyond the field-induced one-third magnetization plateau in Na₃Ni₂BiO₆.

Sulfide-based all-solid-state lithium batteries severely suffer from sulfide electrolyte/Li interfacial instability. Here, authors propose an In and S doping into Li metal to stabilize the Li/Li6PS5Cl interface by constructing built-in electric fields, thereby enabling long-life all-solid-state lithium batteries.

While AI has the potential to improve accuracy and efficiency in breast cancer diagnosis, it remains to be sufficiently tested in complex real-world clinical scenarios. Here, the authors develop BIRD, an end-to-end AI system for breast cancer recognition from ultrasound images, which is tested across large, diverse, and international cohorts.

Hibernating animals tolerate stress through an unknown mechanism that is absent in non-hibernators. Here, the authors show that a snail hibernation-inducing factor they discovered and synthesized, activates PHLPP1, offering cardioprotection in mice hearts through metabolic rewiring and autophagy

It is understood that ice type is dictated by flow conditions, hindering the progress of de-icing technologies. Here, authors propose a strategy for elevating thermal de-icing efficiency by regulating ice type induced by material under flow condition

Here the authors use induced DNA double strand breaks to investigate mechanisms leading to genome instability in human embryos. They find that acentric chromosome fragments fail to segregate, while centric fragments show attrition at the break site, and secondary breakage near the centromere thus explaining the loss of entire chromosomes.

Magnetically controlled swarms of bioadaptive SERS nanoprobes dynamically reconfigure to generate transient electromagnetic hotspots and recruit analytes via convective flows, achieving over tenfold Raman signal amplification for in vivo detection.

Spatial transcriptomics platforms span multicellular to subcellular resolutions but lack methods to reconstruct single-cell transcriptomes across them. Here, the authors introduce STARS, a unified deep learning framework that integrates histology and transcriptomics to infer single-cell gene expression across resolutions.

The origin of asteroid (469219) Kamo‘oalewa, target of China’s Tianwen-2 mission, is debated. Here, the authors show that it probably originated from the Flora family and it resembles asteroid (25143) Itokawa-like composition but with a more space-weathered surface.

This study reports hPSC-derived chamber-like cardiac organoids that self-assemble into structures with outer myocardial and inner endocardial-like layers and a central chamber, serving as a platform for modeling heart development and cardiotoxicity.

A machine learning-driven platform integrated with a portable first-aid device tunes mechanical properties of polyurethane-based bioglues to tissue characteristics for reducing postoperative scarring and reports adhesion on lung, intestine, skin and bone injuries in animal models.

Selective catalysis is vital for greener chemical production, but switching products in one system is difficult. Herein a phosphorus ligand tunes single rhodium atoms on ceria to switch alkene hydroformylation between alcohols and aldehydes.

The authors find an abrupt transition from the parent Mott insulator to a metallic state upon the introduction of an infinitesimal amount of doping in multilayer cuprate superconductors. The innermost CuO₂ planes display gapless Fermi pockets, while the second innermost planes exhibit anisotropic superconducting gaps up to ~33 meV, indicative of robust electron pairing coexisting with strong antiferromagnetic order.

Conventional silent speech decoding devices are limited by dispersion–fidelity conflict, external disturbance, and sensing–communication separation. Here, the authors present an in-sensor communication scarf that captures multi-muscle activities to decode silent speech for speech recognition and assistive interaction applications.

Mitochondrial dysfunction is a cause of impaired fitness of dendritic cells (DCs) in the tumour microenvironment (TME). Here, by integrating algae-derived nanovesicles into genetically engineered DCs overexpressing CCR2, the authors show that the plant vesicle-DC chimera is sufficient to overcome DC mitochondrial dysfunction in the TME and promote antigen presentation, resulting in improved anti tumour immune responses in preclinical models.

Neuromorphic vision sensors lack adaptive sensitivity across wide light intensities. Yang et al. report a complementary vision sensor that fuses superlinear and sublinear light-to-spike encoding in bright and dim environments, respectively, thereby enabling high robustness under challenging conditions.

The authors develop a supercritical mechanochemical process which converts metal oxides to MOFs, enabling rapid, low-cost kilogram-scale production under mild conditions for sustainable manufacturing.

Intelligent materials are an emerging frontier in sustainable technology. The authors introduce Cu/C films as a class of intelligent lubricants that demonstrate capabilities including self-sensing, self-adjustment, and self-repairing.

Malaria parasite resistance to ACT-451840 is linked to mutations in the transporter PfMDR1. Here, authors present cryo-EM structure of PfMDR1, revealing the molecular basis for drug recognition and how specific mutations confer clinical resistance.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Valine metabolism disruption is linked to heart disease, but the mechanisms are unclear. Here, the authors show that ACAD8 deficiency drives isobutyryl-CoA accumulation and histone isobutyrylation, increasing chromatin accessibility and gene expression to promote cardiac hypertrophy, while ACAD8 overexpression reverses these effects.

Skin lesions are common manifestations of systemic lupus erythematosus (SLE). Here, the authors present a spatial transcriptomic atlas of lesional skin from patients with lupus and identify an acute inflammatory signature in SLE, contrasting with chronic damage in tertiary lymphoid structures in discoid lupus.

The role of the tRNAome in virus-host interaction is poorly understood. Here, the authors report a dual role of the host tRNAome showing that it is remodeled by IFN-α to regulate antiviral defenses, yet can be exploited by hepatitis viruses to benefit infection, particularly when host antiviral responses are not induced.

Microbatteries are essential for miniaturized electronics, but it is currently difficult for scale-up fabrication with high efficiency and high consistency. Here, authors report a stack-punching method that enables high-throughput fabrication of microbatteries with high consistency, demonstrating their potential for wearable devices and biohybrid systems.

The characterization of LLPS droplets relies on multimodal approaches to probe their structural and dynamic properties, collectively mapping condensate assembly, disassembly, and interaction networks. However, charge-mediated interactions remain poorly resolved, leaving the ζ-potential landscape of LLPS droplets largely unexplored. Here, the authors present a millisecond flashing electrophoretic separation–laserinduced fluorescence (msFES-LIF) platform enabling ζ-potential profiling of fragile biomolecular condensates at pseudo-single-droplet resolution using nanoliter volumes and nanomolar concentrations.

Telomeric systems are conserved across eukaryotes and may have originated over 1 billion years ago. Here the authors replaced yeast’s telomeres with a bacterial virus system, resulting in a stable functional assembly of DNA molecules up to 2.77 Mb, offering insights into the possible origins of telomeres.

Urban green spaces are linked to better human health, however whether lant species heterogeneity also influences better health outcomes remains unclear. Here, Zhao et al., propose the beta-diversity hypothesis, using data from 72 neighborhoods across Shanghai.

Portal fibrosis, a hallmark of progression in chronic liver diseases, typically develops following biliary injury. This study identifies Clec3b⁺ fibroblasts as key drivers of liver portal fibrosis and demonstrates that a KLF4/periostin signaling axis controls their activation, highlighting potential therapeutic targets for inhibiting fibrosis in biliary diseases.

Achalasia is a rare condition characterised by inability to swallow. Here, the authors use whole-genome sequencing to identify a FAM129C variant associated with the disease and characterise B cell responses towards the GABA-A receptor in a mouse model expressing that variant.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Perovskite solar cells lose efficiency due to defect driven recombination, while solvent based passivation undermines stability and scalable manufacturing. Liu et al. use a solvent-free vapor deposited organic salt to create a conductive interface and passivate defects, boosting device performance.

Here authors develop ultrathin zeolite membranes from heterogeneous nanosheets through topotactic conversion and induction, enabling efficient CO₂ separation and reduced methane decarbonisation cost.