Nature Search

Molecular-scale isotropic 3D super-resolution microscopy via interference localization

ROSE-3D is a single-molecule localization microscopy approach that achieves high isotropic resolution via interferometric localization. The approach is capable of whole-cell and multicolor imaging.

Shihang Luo
Xian’ao Zhao
Lusheng Gu
Research02 Dec 2025
Nature Methods

Volume: 23, P: 183-192
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis

Su, Zhao, Jiang and colleagues identify IGFBP6 as an intrinsic downregulator of the inflammatory response lost in disturbed flow-induced atherosclerotic plaque development, suggesting that its restoration may represent a viable therapeutic strategy.

Meiming Su
Wenqi Zhao
Jianping Weng
Research10 Jan 2025
Nature Cardiovascular Research

Volume: 4, P: 145-162
Comparative single-nucleus RNA-seq analysis revealed localized and cell type-specific pathways governing root-microbiome interactions

Plant roots are exposed to a diverse range of soil-dwelling microbial “friends” and “foes.” Here, via single-nucleus RNA-seq, the authors reveal cell type-specific responses to beneficial and pathogenic microbes in roots and identify regulators of root-microbiome interactions.

Qiuhua Yang
Zhuowen Li
Yi Song
ResearchOpen Access03 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Hepatitis B virus surface antigen drives T cell immunity through non-canonical antigen presentation in mice

The mechanism of HBsAg antigen presentation to T cells during liver HBV infection is incompletely understood. Here, the authors show that in mice, intrahepatic type I dendritic cells acquire HBsAg by MHC-I complexes through cross-dressing for CD8⁺ T cell priming, whereas CD4⁺ T cell responses rely on MHC-II-dependent antigen presentation by B cells in secondary lymphoid tissues.

Xiaofang Li
Wenxuan Sun
Jianhua Li
ResearchOpen Access17 May 2025
Nature Communications

Volume: 16, P: 1-20
Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers

Yu-Hsi Lin
Nikunj Satani
Florian L. Muller
Amendments and Corrections18 Dec 2020
Nature Metabolism

Volume: 3, P: 122
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

The SARS-CoV-2 spike protein contains a multi-basic cleavage site. Here, the authors show how this multi-basic cleavage site affects entry of SARS-CoV-2 into cells and transmission in the hamster model and identify host factors affecting entry of SARS-CoV-2 in a genome-wide CRISPR screen.

Yunkai Zhu
Fei Feng
Rong Zhang
ResearchOpen Access11 Feb 2021
Nature Communications

Volume: 12, P: 1-11
Viral and host factors related to the clinical outcome of COVID-19

Genome sequences from 112 patients with confirmed SARS-CoV-2 infection showed two clades of SARS-CoV-2 virus with similar virulence and clinical outcome, and clinical data from 326 cases suggest that T cell depletion and cytokine bursts are associated with a worse prognosis.

Xiaonan Zhang
Yun Tan
Hongzhou Lu
Research20 May 2020
Nature

Volume: 583, P: 437-440
Numerical investigation of coal dust migration in sealed tunneling environments: A CFD-based study

ZhengHong Gao
Cunbao Deng
Yansheng Wang
ResearchOpen Access31 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.

Tingting Li
Xiaojian Han
Aishun Jin
ResearchOpen Access02 Nov 2021
Nature Communications

Volume: 12, P: 1-11
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers

Oncogenic transformation can render cancer cells dependent on aberrant expression of glycolytic enzyme isoforms. Lin et al. describe a novel enolase inhibitor, POMHEX, that can selectively kill ENO1-deleted glioblastomas.

Yu-Hsi Lin
Nikunj Satani
Florian L. Muller
Research23 Nov 2020
Nature Metabolism

Volume: 2, P: 1413-1426
Prokaryotic evolution shapes specialized communities in long term engineered pit mud ecosystem

Yan Zeng
Xiaozhong Zhong
Zhenghong Xu
ResearchOpen Access24 Sept 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-13
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

Exosomes have diverse physiological roles. Yuan and colleagues show that packaging of antiviral molecules into exosomes, followed by their release, is important in resistance to hepatitis viruses.

Jianhua Li
Kuancheng Liu
Zhenghong Yuan
Research07 Jul 2013
Nature Immunology

Volume: 14, P: 793-803
Systems pathway engineering of Corynebacterium crenatum for improved L-arginine production

Zaiwei Man
Meijuan Xu
Zhenghong Xu
ResearchOpen Access24 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

Shuai Xia
Qiaoshuai Lan
Lu Lu
ResearchOpen Access29 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-10
SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer

Junjian Li
Xiaoliang Chen
Hongxia Wang
ResearchOpen Access23 Jun 2021
Oncogene

Volume: 40, P: 4884-4893
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

Hongzhen Chen
Xuekun Fu
Chao Liang
ResearchOpen Access23 May 2024
Bone Research

Volume: 12, P: 1-17
The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction

Suowen Xu
Yujie Liu
Jianping Weng
ResearchOpen Access12 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-9
A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Zezhong Liu
Jie Zhou
Lu Lu
ResearchOpen Access19 Jan 2022
Cell Research

Volume: 32, P: 269-287
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

Zezhong Liu
Wei Xu
Shibo Jiang
ResearchOpen Access27 Nov 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-10
Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury

Congjian Shi
Zhenghong Zhang
Zhengchao Wang
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-13
Research on the synergistic modification effect and the interface mechanism of GO/SBS compound-modified asphalt based on experiments and molecular simulations

Qing Zeng
Yaru Liu
Zhenghong Xu
ResearchOpen Access01 Mar 2023
Scientific Reports

Volume: 13, P: 1-16
The Detection and Characterization of Herpes Simplex Virus Type 1 in Confirmed Measles Cases

Chongshan Li
Yunyi Li
Zhenghong Yuan
ResearchOpen Access04 Sept 2019
Scientific Reports

Volume: 9, P: 1-9
A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts

Bingqing Xie
Da Sun
Hongkui Deng
ResearchOpen Access03 Jul 2019
Cell Research

Volume: 29, P: 696-710
Assessing causal relationship between circulating cytokines and age-related neurodegenerative diseases: a bidirectional two-sample Mendelian randomization analysis

Zihan Yin
Jiao Chen
Fanrong Liang
ResearchOpen Access29 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Structural insight into substrate recognition by histone demethylase LSD2/KDM1b

Fei Chen
Huirong Yang
Yanhui Xu
Correspondence29 Jan 2013
Cell Research

Volume: 23, P: 306-309
National-scale 10-m maps of cropland use intensity in China during 2018–2023

Bingwen Qiu
Baoli Liu
Fangzheng Wu
ResearchOpen Access26 Jun 2024
Scientific Data

Volume: 11, P: 1-12
Survival of SARS-COV-2 under liquid medium, dry filter paper and acidic conditions

Zhiping Sun
Xia Cai
Di Qu
CorrespondenceOpen Access14 Aug 2020
Cell Discovery

Volume: 6, P: 1-4
Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

Jinkai Zang
Chenjian Gu
Zhong Huang
CorrespondenceOpen Access03 Sept 2020
Cell Discovery

Volume: 6, P: 1-4
A Salmonella enterica serovar Typhi plasmid induces rapid and massive apoptosis in infected macrophages

Shuyan Wu
Yuanyuan Li
Zhenghong Qin
Research17 May 2010
Cellular & Molecular Immunology

Volume: 7, P: 271-278
miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma

Yuqiong Wang
Xiyu Zhang
Zhaojian Liu
Research11 Aug 2017
Cell Death & Differentiation

Volume: 24, P: 2089-2100

Search

Molecular-scale isotropic 3D super-resolution microscopy via interference localization

Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis

Comparative single-nucleus RNA-seq analysis revealed localized and cell type-specific pathways governing root-microbiome interactions

Hepatitis B virus surface antigen drives T cell immunity through non-canonical antigen presentation in mice

Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

Viral and host factors related to the clinical outcome of COVID-19

Numerical investigation of coal dust migration in sealed tunneling environments: A CFD-based study

Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

An enolase inhibitor for the targeted treatment of ENO1-deleted cancers

Prokaryotic evolution shapes specialized communities in long term engineered pit mud ecosystem

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

Systems pathway engineering of Corynebacterium crenatum for improved L-arginine production

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer

Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury

Research on the synergistic modification effect and the interface mechanism of GO/SBS compound-modified asphalt based on experiments and molecular simulations

The Detection and Characterization of Herpes Simplex Virus Type 1 in Confirmed Measles Cases

A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts

Assessing causal relationship between circulating cytokines and age-related neurodegenerative diseases: a bidirectional two-sample Mendelian randomization analysis

Structural insight into substrate recognition by histone demethylase LSD2/KDM1b

National-scale 10-m maps of cropland use intensity in China during 2018–2023

Survival of SARS-COV-2 under liquid medium, dry filter paper and acidic conditions

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

A Salmonella enterica serovar Typhi plasmid induces rapid and massive apoptosis in infected macrophages

miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma

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