Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
OPRK1 drives SLC9A3R1 progression to neuroendocrine prostate cancer

Linghui Liang
Zhiyi Shen
Ruizhe Zhao
ResearchOpen Access07 Dec 2025
Cell Death & Disease

Volume: 17, P: 1-14
The haplotype-resolved telomere-to-telomere genome and OMICS analyses reveal genetic responses to tapping in rubber tree

Authors report the assembly of the haplotype-resolved and telomere-to-telomere genome of a key rubber tree variety and uncover major structural variations. It is also revealed that jasmonic acid enhances rubber yield by activating the mevalonate pathway during tapping.

Chaochao Li
Yuan Yuan
Han Cheng
ResearchOpen Access07 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial

Evidence for the treatment of patients with mild-to-moderate COPD is limited. Here, the authors show that long-term treatment with high-dose N-acetylcysteine neither significantly reduced the annual rate of total exacerbations nor improve lung function in patients with mild-tomoderate COPD.

Yumin Zhou
Fan Wu
Li Chen
ResearchOpen Access30 Sept 2024
Nature Communications

Volume: 15, P: 1-11
Tunable magnetic field architecture for bioinspired magnetic pressure sensors featuring low detection limits and wide sensing range

Huiyun Xiao
Feng Xu
Run-Wei Li
ResearchOpen Access28 Dec 2025
npj Flexible Electronics

Volume: 10, P: 1-12
Multi-heterojunctioned plastics with high thermoelectric figure of merit

Thermoelectric plastics with a high figure of merit, suppressed thermal conductivity and an enhanced power factor are realized by combining layered and bulk heterojunctions to create a polymeric multi-heterojunction.

Dongyang Wang
Jiamin Ding
Daoben Zhu
Research24 Jul 2024
Nature

Volume: 632, P: 528-535
Self-cleaning electrode for stable synthesis of alkaline-earth metal peroxides

This work introduces a reaction system that enables the in situ conversion of H₂O₂ generated by 2e⁻ ORR at the self-cleaning electrode surface into alkaline-earth metal peroxides. The solid oxidizer CaO₂ exhibits comparable efficiency to H₂O₂ for tetracycline degradation.

Minli Wang
Jinhuan Cheng
Zhiyi Lu
Research28 Oct 2024
Nature Nanotechnology

Volume: 20, P: 67-74
Mapping enzyme activity in living systems by real-time mid-infrared photothermal imaging of nitrile chameleons

Real-time mid-infrared photothermal imaging of nitrile chameleons enables simultaneous, multiplexed measurement of enzymatic activity in living systems and is poised to reveal the spatiotemporal regulation of enzymes in health and disease.

Hongjian He
Jiaze Yin
Ji-Xin Cheng
Research08 Jan 2024
Nature Methods

Volume: 21, P: 342-352
Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs targeting SRD5A2.

Qingpin Xiao
Lei Wang
Cheng Zhang
ResearchOpen Access27 Oct 2020
Nature Communications

Volume: 11, P: 1-11
Targeted deprivation of STAT6 sensitizes acute lymphoblastic leukemia cells to cytarabine in vivo and in vitro: clinical implications

Shuzhang Sun
Yixuan Cheng
Ning Xiao
ResearchOpen Access02 Sept 2025
Cell Death & Disease

Volume: 16, P: 1-10
Reversible and selective ion intercalation through the top surface of few-layer MoS₂

Electrochemical ion intercalation in 2D layered materials is known to occur through the material’s edges, accompanied by frequent structural deformations. Here the authors show that in MoS2 flakes where the edges have been sealed, a reversible and ion-selective intercalation occurs through the top surface via the intrinsic defects.

Jinsong Zhang
Ankun Yang
Yi Cui
ResearchOpen Access11 Dec 2018
Nature Communications

Volume: 9, P: 1-9
Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

Integrated alveolus and blood–brain barrier tissue chips recapitulate neuropathogenesis associated with infection by SARS-CoV-2.

Peng Wang
Lin Jin
Jianhua Qin
Research22 Jun 2023
Nature Biomedical Engineering

Volume: 8, P: 1053-1068
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

LRP5/6 is a Wnt co-receptor essential for Wnt/β-catenin signaling. X-ray crystallography and electron microscopy analyses now reveal that the LRP6 extracellular ligand-binding domain is composed of two pairs of rigid blocks connected by a short hinge. The structure of the LRP6–DKK1c complex also shows how DKK1 may potently inhibit Wnt/β-catenin signaling through its binding to these structural blocks.

Zhihong Cheng
Travis Biechele
Wenqing Xu
Research09 Oct 2011
Nature Structural & Molecular Biology

Volume: 18, P: 1204-1210
Optimization of energy management strategies for multi-mode hybrid electric vehicles driven by travelling road condition data

Hongxia Wang
Cheng Chang
Yubo Liu
ResearchOpen Access12 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
Characteristics, licensing, and ethical considerations of openly accessible oral-maxillofacial imaging datasets: a systematic review

Jing Hao
Andrew Nalley
Kuo Feng Hung
ResearchOpen Access05 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-22
Orthosteric and allosteric action of the C5a receptor antagonists

Structures of human C5aR in ternary complexes with the peptide antagonist PMX53 and a non-peptide antagonist, either avacopan or NDT9513727, reveal the orthosteric effects of PMX53, the allosteric effects of the non-peptide drugs and structural details of signal transduction by C5aR.

Heng Liu
Hee Ryung Kim
Cheng Zhang
Research04 Jun 2018
Nature Structural & Molecular Biology

Volume: 25, P: 472-481
Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-of-concept study suggests that HIV-1 elimination is possible.

Prasanta K. Dash
Rafal Kaminski
Howard E. Gendelman
ResearchOpen Access02 Jul 2019
Nature Communications

Volume: 10, P: 1-20
Dataset on the effects of psychological care on depression and suicide ideation in underrepresented children

Xuerong Liu
Wei Li
Zhiyi Chen
ResearchOpen Access19 Mar 2024
Scientific Data

Volume: 11, P: 1-7
Public mental health problems during COVID-19 pandemic: a large-scale meta-analysis of the evidence

Xuerong Liu
Mengyin Zhu
Zhiyi Chen
ResearchOpen Access09 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-10
KLF5 activates lncRNA DANCR and inhibits cancer cell autophagy accelerating gastric cancer progression

Zhiyi Cheng
Guiyuan Liu
Xiaojun Zhao
ResearchOpen Access21 Sept 2021
npj Genomic Medicine

Volume: 6, P: 1-10
Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma

Wei Chen
Hao Zhang
Yuanyuan Zhang
ResearchOpen Access02 Nov 2018
Oncogenesis

Volume: 7, P: 1-11

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