Nature Search

Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents

This study shows that Galectin-3 promotes wound healing by binding to and undergoing phase separation with integrin α5β1, a process disrupted by AGEs in pre-clinical models of diabetes. Topical Galectin-3 restored healing in synergy with insulin.

Zhongyu Zhang
Zhengde Zhao
Sifan Chen
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-23
No ureteral catheter mini percutaneous nephrolithotomy (NUC-mPCNL) achieves enhanced recovery after surgery (ERAS)

Xuwen Li
Zhongyu Tan
Wei Liu
ResearchOpen Access07 Nov 2024
Scientific Reports

Volume: 14, P: 1-7
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Multivariate metal-organic frameworks enable chemical shift-encoded MRI with femtomolar sensitivity for biological systems

Conventional entrapped ¹²⁹Xe with low signal intensity limits in vivo applications. Here, the authors developed a MOF-based reporter that enhances signal intensity, achieves femtomolar detection, and enables chemical shift-encoded MRI in rat lungs.

Qingbin Zeng
Quer Yue
Xin Zhou
ResearchOpen Access24 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Author Correction: Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation

Haoxuan Li
Guanqun Wang
Chuan He
Amendments and Corrections21 Jan 2025
Nature Plants

Volume: 11, P: 376
TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers

Weihao Zhang
Jiajie Lin
Zhongyu Xie
ResearchOpen Access23 Dec 2025
Cell Death & Disease

Volume: 16, P: 1-14
Response to comment on: A novel rat model for investigating erectile function after nerve-sparing radical prostatectomy

Yashou Guo
Ronggui Tao
Dalin He
Comments & Opinion08 Jan 2026
International Journal of Impotence Research

P: 1-2
A novel rat model for investigating erectile function after nerve-sparing radical prostatectomy

Yashou Guo
Ronggui Tao
Dalin He
ResearchOpen Access26 Jul 2025
International Journal of Impotence Research

P: 1-7
RNA m⁵C oxidation by TET2 regulates chromatin state and leukaemogenesis

Chromatin-associated retrotransposon RNA 5-methylcytosine can be recognized by the methyl-CpG-binding-domain protein MBD6, which guides deubiquitination of nearby monoubiquitinated Lys119 of histone H2A to promote an open chromatin state in TET2-deficient cells.

Zhongyu Zou
Xiaoyang Dou
Chuan He
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 986-994
Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp³)-H olefination mediated by donor/donor carbenes

Furanocembranoid-like natural products with the alkene-substituted furan scaffold display a range of biological activities, but are difficult to access. Here, the authors report a modular biomimetic strategy to synthesise diverse alkene-substituted furan-containing macrolactams via palladium-catalysed unactivated Csp³-H olefination.

Jiping Hao
Xueying Guo
Weibo Yang
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-11
Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation

The comprehensive and quantitative mapping of pseudouridine (Ψ) sites across four plant species provides critical resources for plant Ψ research, and reveals multilayered translation regulation through rRNA, tRNA and mRNA pseudouridylation in plants.

Haoxuan Li
Guanqun Wang
Chuan He
Research09 Jan 2025
Nature Plants

Volume: 11, P: 234-247
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins

Chen et al. report that the YTHDF family of m⁶A-RNA-binding proteins can be differentially regulated by the post-translational modification O-GlcNAcylation, leading to differential regulation of the YTHDF proteins on translation and phase separation.

Yulin Chen
Ruixi Wan
Shixian Lin
Research09 Nov 2023
Nature Cell Biology

Volume: 25, P: 1676-1690
Spin Seebeck in the weakly exchange-coupled Van der Waals antiferromagnet across the spin-flip transition

The authors find the magnon spin transport in CrSP₄/Pt (Ta) can be effectively modulated through adjustments in temperature and applied magnetic field, particularly at the spin-flip field.

Xue He
Shilei Ding
Rui Wu
ResearchOpen Access28 Mar 2025
Nature Communications

Volume: 16, P: 1-8
Analyses of a chromosome-scale genome assembly reveal the origin and evolution of cultivated chrysanthemum

Chrysanthemum is an important ornamental species with great economic value. Here, the authors assemble the haploid genome of C. morifolium, reveal its segmental allopolyploid genomic composition (AA’B), and identify candidate genes associated with flower development, petal shape, and flower colour.

Aiping Song
Jiangshuo Su
Fadi Chen
ResearchOpen Access11 Apr 2023
Nature Communications

Volume: 14, P: 1-15
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing

This work introduces ARTR-seq for in situ measurement of RNA-binding protein (RBP) binding sites, which has been demonstrated in a small number of cells and for capturing dynamic RBP binding within short timeframes.

Yu Xiao
Yan-Ming Chen
Chuan He
ResearchOpen Access10 Jan 2024
Nature Methods

Volume: 21, P: 247-258
Genetic analyses support the contribution of mRNA N⁶-methyladenosine (m⁶A) modification to human disease heritability

Quantitative trait locus (QTL) mapping of N⁶-methyladenosine (m⁶A) in human cells highlights the role of RNA-binding proteins, RNA secondary structure and context-dependent m⁶A effects. m⁶A QTLs are enriched in loci associated with immune and blood-related traits.

Zijie Zhang
Kaixuan Luo
Chuan He
Research29 Jun 2020
Nature Genetics

Volume: 52, P: 939-949
N6-methyladenosine: a key regulator in ocular disease mechanisms and treatment

Yumeng Lin
Liuzhi Zeng
Qingsong Yang
ReviewsOpen Access28 Nov 2025
Cell Death Discovery

Volume: 12, P: 1-32
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

EGFR is frequently constitutively active in glioblastoma (GBM). Here, the authors show that EGFR induces YTHDF2 protein stabilization, which reduces cholesterol homeostasis through an RNA m6A methylation dependent molecular mechanism to promote GBM tumourigenesis.

Runping Fang
Xin Chen
Suyun Huang
ResearchOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1-17
Unraveling the mechanisms of LncRNAs in cervical cancer: a comprehensive review

Lusheng Liu
Zhongyu Han
Guizhi Ma
ReviewsOpen Access13 Dec 2025
Cell Death Discovery

Volume: 12, P: 1-15
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

Aurora kinase A is a mitotic kinase that facilitates G2/M events. Here the authors show that in breast cancer cells Aurora kinase A has a kinase-independent function in the nucleus by activating the MYC promoter in cooperation with hnRNP K, enhancing the breast cancer stem cell phenotype.

Feimeng Zheng
Caifeng Yue
Quentin Liu
ResearchOpen Access19 Jan 2016
Nature Communications

Volume: 7, P: 1-17
RNA modification systems as therapeutic targets

RNA can be chemically modified by enzymes such as methyltransferases to regulate RNA metabolism, gene expression and other biological processes. This Review mainly focuses on the disease-relevant N⁶-methyladenosine RNA modification pathway and discusses efforts to therapeutically target N⁶-methyladenosine writer, eraser and reader proteins.

Linda Zhang
Jiangbo Wei
Chuan He
Reviews17 Sept 2025
Nature Reviews Drug Discovery

Volume: 25, P: 59-78
Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis

Wenhui Yu
Zhongyu Xie
Huiyong Shen
ResearchOpen Access07 Jun 2023
Bone Research

Volume: 11, P: 1-16
Knowledge, attitude and practice of rehabilitation management of the caregivers of pediatric patients with hemiplegia

Ya Guo
Xiaoli Li
Yuanyuan Lai
ResearchOpen Access28 May 2025
Scientific Reports

Volume: 15, P: 1-9
Simulation and assimilation of the digital human brain

The Digital Brain platform is capable of simulating spiking neuronal networks at the neuronal scale of the human brain. The platform is used to reproduce blood-oxygen-level-dependent signals in both the resting state and action, thereby predicting the visual evaluation scores.

Wenlian Lu
Xin Du
Yicong Zhao
Research19 Dec 2024
Nature Computational Science

Volume: 4, P: 890-898
Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells

Large tumors induce anemia and expansion of CD45⁺ immature erythroid cells, which represent a major immunosuppressive population in the spleen, contributing to systemic suppression of T cell immunity in late-stage cancer.

Lintao Zhao
Ran He
Bo Zhu
Research08 Oct 2018
Nature Medicine

Volume: 24, P: 1536-1544
Exploring the role of ferroptosis in esophageal cancer: mechanisms and therapeutic implications

Defeng Zhao
Wenze Li
Wenya Li
ReviewsOpen Access25 Aug 2025
Cell Death Discovery

Volume: 11, P: 1-22
Cenozoic evolution of spring persistent rainfall in East Asia and North America driven by paleogeography

The emergence of the spring persistent rainfall in East Asia since the Miocene and its decline in North America was determined by paleogeographic events through mid-latitude Rossby wave trains, as revealed by climate models integrated with climate proxies.

Linqiang He
Tianjun Zhou
Wenxia Zhang
ResearchOpen Access27 Feb 2025
Communications Earth & Environment

Volume: 6, P: 1-8
Study on the dynamic response characteristics of lining structures in large-section tunnel blasting using JH-2 model analysis

Fengting Li
Ke Wu
Zhongyu Dou
ResearchOpen Access07 May 2024
Scientific Reports

Volume: 14, P: 1-18
FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

Weiqiang Lu
Feixiong Cheng
Jin Huang
ResearchOpen Access29 Jan 2015
Scientific Reports

Volume: 5, P: 1-10
Evaluation of the neural function of nonhuman primates with spinal cord injury using an evoked potential-based scoring system

Jichao Ye
Mengjun Ma
Yuanshan Zeng
ResearchOpen Access15 Sept 2016
Scientific Reports

Volume: 6, P: 1-13
The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain

Jiajing Wu
Jianhui Nie
Weijin Huang
ResearchOpen Access19 Jan 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-10
Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice

Shihui Sun
Lei He
Yansong Sun
Correspondence17 Mar 2021
Cellular & Molecular Immunology

Volume: 18, P: 1070-1073
Haplotype Polymorphism in the Alpha-2B-Adrenergic Receptor Gene Influences Response Inhibition in a Large Chinese Sample

Xuemei Lei
Chuansheng Chen
Qi Dong
Research04 Jan 2012
Neuropsychopharmacology

Volume: 37, P: 1115-1121
Progression of m⁶A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming

Xuan Han
Yu Zhu
Yanming Zhang
ReviewsOpen Access20 Jul 2024
Cell Death Discovery

Volume: 10, P: 1-18

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