Search

Foamy macrophages are key to atherosclerosis but poorly understood. Here, the authors show that GPNMB regulates lipoprotein processing in macrophages, exacerbating pathological lipid accumulation, and revealing it as a therapeutic target whose inhibition reduces atherosclerosis in mice.

Mechanistic insight into how SARS-CoV-2 nsp14 methyltransferase activity installs m⁷G on host RNAs to drive stress-granule assembly.

Zhu et al. combine neonatal and twin imaging to unveil innate functional connectivity patterns in the temporal pole, a hub region for semantic memory. These patterns are present in neonates, heritable, and linked to semantic functions in adults.

A focused-ultrasound-mediated mechanogenetics approach enables the genetic modification of cancer cells near solid tumours to activate chimeric antigen receptor T cell response and achieve tumour suppression at distinct sites.

The response of the phosphorus (P) cycle to permafrost thaw is unknown, but has implications for carbon dynamics. This study assesses changes in the P cycle upon abrupt thaw and shows accelerated soil P cycling and increased plant uptake, which may boost primary production and partially offset soil carbon loss.

There remains a critical need for precise control of CRISPR-based technologies. Here, the authors develop a focused ultrasound (FUS)-controllable CRISPR toolbox, allowing the noninvasive and spatiotemporal control of genomic/epigenomic reprogramming for cancer treatment combined with CAR-T therapy.

Metal-based nanostructures offer a solution to scale down photonics to the nanoscale. Sorgeret al. directly demonstrate waveguiding of ultra-small propagating waves at visible and near-infrared frequencies using NSOM imaging, with the potential for nanoscale photonic applications such as bio-sensing.

Single-phase Na_xV₂(PO₄)₃ compositions obtained by annealing mixtures of Na₃V₂(PO₄)₃ and NaV₂(PO₄)₃ enable the complete electrochemical extraction of Na⁺ through the activation of the V⁴⁺/V⁵⁺ couple. This results in a substantial increase in the energy density of such Na super ionic conductor electrodes when used in sodium batteries.

Maternal polycystic ovary syndrome may impact the offspring’s long-term health. Here, the authors show that children of mothers with polycystic ovary syndrome have an increased risk of cardiovascular disease in childhood and young adulthood.

Cell type deconvolution is crucial for studying disease and development. Here, the authors present SCCAF-D, a workflow that reduces batch effects and achieves high correlation across tissues, offering key insights into cell proportion changes in non-alcoholic fatty liver disease.

This study maps chromatin accessibility at single-cell resolution in rice and related grasses, revealing how regulatory DNA elements evolve across cell types and species and identifying potential silencers that control gene expression.

High-quality genome sequence of cultivated peanut comprising 2.54 Gb with 20 pseudomolecules and 83,709 protein-coding gene models provides insights into genome evolution and the genetic mechanisms underlying seed size and leaf resistance in peanut.

Wang and colleagues perform single-cell profiling of human ovarian cancer samples from five anatomic sites, revealing dynamics of the immune microenvironment in malignant ascites and cell subtypes that may play a role in chemotherapy response.

Analysis of bacterial, archaeal, fungal and viral species in the gut microbiome of patients with colorectal cancer identified cross-kingdom interactions and multi-kingdom markers of disease.

Imaging non-repetitive loci in living cells remains challenging. Here, the authors engineered an inducible system whereby biomolecular assemblies can be guided to specific genomic loci by a nuclease-defective Cas9, allowing the simultaneous imaging and manipulation of the loci.

While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.

A fluoropolymer-based cancer nanovaccine that delivers antigens directly to the cytosol of dendritic cells and elicits strong antitumour immune responses inhibiting tumour growth in animal models can be used to produce personalized treatment for post-surgical immunotherapy.

This study identifies SCEP3 as a conserved central element of the plant synaptonemal complex. SCEP3 is critical for synapsis, heterochiasmy and crossover interference. SCEP3 also promotes a subset of crossover events.

Ovarian aging has an important role in health and fertility; however, the molecular mechanisms underlying it remain incompletely understood. Here the authors use single-cell and spatial transcriptomics in reproductively young, middle-aged and older human ovarian tissue to elucidate ovarian aging. They describe spatiotemporal changes in ovarian cells and highlight the important regulatory role of FOXP1.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

The activity of engineered T cells within tumours can be controlled via the heat generated by pulses of focused ultrasound by modifying the cells to express a chimeric antigen receptor under the control of a promoter for the heat-shock protein.

The use of electric fields to control spin currents, which is one of the goals of modern spintronics, has now been extended to control the valley degree of freedom in a 2D semiconductor.

The second messenger cAMP modulates a wide range of important biological processes. Here, the authors developed a fluorescent indicator termed G-Flamp1, which can accurately report levels of cAMP in living cells.

In this work, the authors investigated on the interaction of biomolecular condensates with membranes and report that they can exhibit two wetting transitions modulated by membrane or milieu composition. Condensate adhesion can trigger intriguing ruffling of the membrane interface into complex finger-like structures.

Brain structural traits are highly heritable and have been linked to disease. Here the authors have used gene expression data to perform a transcriptome-wide association study on 211 brain structural traits, discovering 273 associated genes.

A series of long-lived excitons in a monolayer of tungsten disulphide are found to have strong binding energy and an energy dependence on orbital momentum that significantly deviates from conventional, three-dimensional, behaviour.

Free-standing monolayers of MoS₂ exhibit piezoelectric behaviour due to inversion symmetry breaking.

Radiofrequency ablation (RFA) is a minimally invasive tumor ablation method, however incomplete ablation and the induction of an immunosuppressive microenvironment limit its efficacy in the clinic. Here the authors design a pH-responsive lipoxidase-loaded nanoreactor, that by triggering ferroptosis and anti-tumor immunity, amplify the therapeutic benefits of RFA in preclinical models.

It is shown that rhombohedral stacked MoS₂ can enable scalable photovoltaic effects induced by spontaneous polarization throughout few-micrometre-sized exfoliated flakes. This is exploited in a graphene–MoS₂-based photovoltaic device.

Nanocatalysts and single‐atom catalysts are generally considered as two categories with distinct performances. Here, in situ TEM study of catalytic methane pyrolysis over nanoporous Au reveals a highly dynamic process where co‐catalysis exists among various catalyst forms.

Synthesizing precise conjugated nanostructures on a surface requires fine control over the covalent reaction pathways. Here, the authors show that reversible coordinative bonds can be used to template on-surface C-C coupling reactions, guiding the formation of porous organic nanoribbons.

DILITracer: an AI-driven ternary hepatotoxicity classification model via spatiotemporal analysis of human liver organoids brightfield images.

Association analyses using resting-state functional magnetic resonance images identify common genetic variants influencing intrinsic brain activity. Variation in brain function is genetically correlated with several neuropsychiatric traits.

Genome-wide analyses in 19,629 individuals identify 365 independent variants associated with brain volumetric phenotypes. The study provides insight into the overlapping genetic architecture of brain volume measures and cognitive and mental health traits.