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Mechanistic insight into how SARS-CoV-2 nsp14 methyltransferase activity installs m⁷G on host RNAs to drive stress-granule assembly.

Foamy macrophages are key to atherosclerosis but poorly understood. Here, the authors show that GPNMB regulates lipoprotein processing in macrophages, exacerbating pathological lipid accumulation, and revealing it as a therapeutic target whose inhibition reduces atherosclerosis in mice.

Chemoautotrophic carbon fixation is vital for evaluating permafrost carbon-climate feedback, but has been largely ignored. Here the authors find that dark carbon fixation predominates ~1/3 of the investigated thermokarst lakes on the Tibetan Plateau.

Although hyperlenses made of metamaterials can image sub-diffraction-limited objects, they are limited to one-dimensional magnification and ultraviolet frequencies. Here, the authors demonstrate a spherical hyperlens for visible light far-field imaging, with a resolution of 160 nm in both lateral dimensions.

The response of the phosphorus (P) cycle to permafrost thaw is unknown, but has implications for carbon dynamics. This study assesses changes in the P cycle upon abrupt thaw and shows accelerated soil P cycling and increased plant uptake, which may boost primary production and partially offset soil carbon loss.

Metal-based nanostructures offer a solution to scale down photonics to the nanoscale. Sorgeret al. directly demonstrate waveguiding of ultra-small propagating waves at visible and near-infrared frequencies using NSOM imaging, with the potential for nanoscale photonic applications such as bio-sensing.

This study maps chromatin accessibility at single-cell resolution in rice and related grasses, revealing how regulatory DNA elements evolve across cell types and species and identifying potential silencers that control gene expression.

High-order correlated states in atomically thin transition metal dichalcogenides may be facilitated by long-lived optically dark excitons. Here, the authors report experimentally the emergence of neutral and charged biexciton species at low light intensities in encapsulated WSe₂ monolayers.

Liu and colleagues demonstrate that exchanging personnel between cities is more effective at reducing firm-level water pollution than copying policies from one place to apply them elsewhere. The findings highlight the promise of intercity personnel exchange for improved water governance.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

The reductive coupling of alcohols and nitro compounds typically yields amine products. Here the authors show that MgO nanoclusters catalyse this reaction, giving unsaturated C = N containing products.

The authors resolved large scale fresh and recirculated submarine groundwater discharge (SGD) and their associated nutrient fluxes in China’s coastal seas, revealing a dominant role of SGD in nutrient budgets.

High-quality genome sequence of cultivated peanut comprising 2.54 Gb with 20 pseudomolecules and 83,709 protein-coding gene models provides insights into genome evolution and the genetic mechanisms underlying seed size and leaf resistance in peanut.

IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3 suppresses IFITM1 via the degradation-related protein DDX5.

Analysis of bacterial, archaeal, fungal and viral species in the gut microbiome of patients with colorectal cancer identified cross-kingdom interactions and multi-kingdom markers of disease.

Cell type deconvolution is crucial for studying disease and development. Here, the authors present SCCAF-D, a workflow that reduces batch effects and achieves high correlation across tissues, offering key insights into cell proportion changes in non-alcoholic fatty liver disease.

Imaging non-repetitive loci in living cells remains challenging. Here, the authors engineered an inducible system whereby biomolecular assemblies can be guided to specific genomic loci by a nuclease-defective Cas9, allowing the simultaneous imaging and manipulation of the loci.

A series of long-lived excitons in a monolayer of tungsten disulphide are found to have strong binding energy and an energy dependence on orbital momentum that significantly deviates from conventional, three-dimensional, behaviour.

Ovarian aging has an important role in health and fertility; however, the molecular mechanisms underlying it remain incompletely understood. Here the authors use single-cell and spatial transcriptomics in reproductively young, middle-aged and older human ovarian tissue to elucidate ovarian aging. They describe spatiotemporal changes in ovarian cells and highlight the important regulatory role of FOXP1.

Synthesizing precise conjugated nanostructures on a surface requires fine control over the covalent reaction pathways. Here, the authors show that reversible coordinative bonds can be used to template on-surface C-C coupling reactions, guiding the formation of porous organic nanoribbons.

Wang and colleagues perform single-cell profiling of human ovarian cancer samples from five anatomic sites, revealing dynamics of the immune microenvironment in malignant ascites and cell subtypes that may play a role in chemotherapy response.

The use of electric fields to control spin currents, which is one of the goals of modern spintronics, has now been extended to control the valley degree of freedom in a 2D semiconductor.

Free-standing monolayers of MoS₂ exhibit piezoelectric behaviour due to inversion symmetry breaking.

A single-cell transcriptomic study from the Human Cell Atlas integrating over 11 million brain cells from 70 studies uncovers differences across human brain regions and identifies rare progenitor and microglia subtypes.

Valleys in momentum space provide a degree of freedom that could be exploited for applications. A demonstration of valley pseudospin control now completes the generation–manipulation–detection paradigm, paving the way for valleytronic devices.

Only in areas of agricultural fields where nitrate and dissolved organic carbon availability were high could soil moisture stimulate high nitrous oxide emissions, according to a conceptual model based on spatial measurements of emissions and soil properties.

DILITracer: an AI-driven ternary hepatotoxicity classification model via spatiotemporal analysis of human liver organoids brightfield images.

Genome-wide analyses in 19,629 individuals identify 365 independent variants associated with brain volumetric phenotypes. The study provides insight into the overlapping genetic architecture of brain volume measures and cognitive and mental health traits.

Moderate transportation PA is associated with a lower risk of new-onset hypertension among Chinese adults.