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Davies, Black et al., investigate the frequency, cause, molecular associations, and prognostic implications of homologous recombination deficiency (HRD) in primary estrogen receptor-positive and HER2-negative breast cancer. HRD was less frequent (8.4%), induced mainly by alterations acting on BRCA1/BRCA2/RAD51C/PALB2, but not associated with patient outcome after adjuvant systemic therapy.

Spatially resolved transcriptomic, metabolomic and proteomic analyses of human liver samples highlight the role of lipid-associated macrophages in metabolic dysfunction-associated steatotic liver disease.

The authors show that, in addition to rising daily mean near-surface air temperature, the faster increase in daily maximum temperature compared to minimum temperature has contributed to increasing near-surface air dryness since the 1980s.

Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8⁺ T cell epitope recognition.

Significant efforts are needed to leap from the identification of trait-associated genetic variants to the revealing of the causal gene. Here, the authors translate genomic variants into gene-level functional haplotypes for GWAS and identify a gene encoding ferulic acid 5-hydroxylase 1 is responsible for superior cotton fiber quality.

SERPINB9 (SPB9) has been reported as a critical factor in the resistance to immunotherapy but its role in chemosensitivity remains unknown. Here this work reports that gemcitabine (GEM) treatment leads to upregulation of SPB9 in vitro/vivo, therefore engineer a nanocarrier co-delivering GEM and siSPB9 for preclinical pancreatic cancer treatment.

A method to synthesize non-van der Waals MAX phases and van der Waals layered early transition metal Xide chalcogenides (TMXCs) is developed through editing of covalent M–A/M–X sublayers. Exfoliated monolayer TMXCs resemble MXenes but feature tunable oxidation states, making the materials promising for applications in energy storage and catalysis.

More than 80% of vegetation burned globally regained its pre-fire level of productivity within 2 years, according to an assessment of post-fire vegetation productivity from 2004 to 2021.

Chromosome-scale genome assembly of a vegetable-type elite pea cultivar ZW1 and population analyses using resequencing data of 314 accessions provide insights into the genetic basis of Mendelian and other agronomic traits.

The authors find a significant increase in daily maximum temperature warming rates, while daily minimum temperatures remain stable over land in recent decades. This may be due to reduced cloud cover, leading to increased incoming solar radiation.

A pro-tumorigenic role of iRhom1 has been described in several cancer types. Here the authors show that iRhom1 regulates sensitivity to chemotherapy and immune response, as well they report that CD44 targeting nanoparticle-mediated co-delivery of iRhom1 pre-siRNA promotes anti-tumor immune responses in preclinical cancer models.

Downregulation of specific proteins named scramblases might enhance tumour immunosuppression. In this paper the authors first show that the scramblase Xrk8 is overexpressed in tumour cells upon treatment with chemotherapeutics, and then develop a nanomedicine platform for co-delivery of a cancer prodrug and an siRNA directed against the Xrk8 gene, showing therapeutic effect and enhanced immune response in animal tumour models.

The synthesis of covalent organic frameworks (COFs) by a soft-template methodology is challenging. Here, the authors attach the soft templates to the COFs backbone via ion bonds, avoiding crystallization incompatibilities and allowing subsequent removal of the template by ion exchange for enhanced U(VI)/Th(IV) adsorption performance.

Although many natural products and drug molecules contain N–N linkages, the chemistry of N–N coupling is somewhat underdeveloped. Now, a nitrene-mediated intermolecular N–N coupling of dioxazolones and arylamines that relies on iridium or iron catalysis has been developed. These reactions offer a simple and efficient method for the synthesis of hydrazides from readily available precursors.

A study presents the results of surveillance for SARS-CoV-2 in animal and environmental samples from a market linked to early human cases of coronavirus disease 2019.

The permanent inhabitants exposure to the hypoxia environment long-termly, it may impose negative impact on hypertension. There were 32 studies (86,487 participants) were included for this study review and analyses. We found a curvilinear association between altitude and prevalence of hypertension with peak about 3300 m.

Sulfenamides are organosulfur reagents that feature labile S–N bonds and have potential applications in chemical synthesis. Here, the authors report the preparation of N-acyl sulfenamides via copper-catalyzed S-amidation of thiols with dioxazolones; These N-acyl sulfenamides can be used to prepare unsymmetrical disulfides via reaction with thiols.

Material interfaces are highly crucial to improve device performances. Here, the authors report interfacial reconstruction at the Au {001} substrate surface and the top MoS₂ and WS₂ monolayers due to the formation of a metastable interfacial Au₄S₄ phase. The reconstructed interface results in a p-type Schottky contact with reduced barrier height.

A probe incorporating 1,024 simultaneously recorded channels with shank length up to 90 mm exhibits high chronic recording stability and enables brain-wide large-scale neural population recordings with single-cell resolution in non-human primates.

Near-infrared-emitting tin-based perovskite light-emitting diodes with greatly improved efficiency are realized by the use of additives during fabrication.

Wildfires intensify in central but weaken in eastern Siberia when midsummer precipitation is above normal in western Tibet and below normal in the east, leading to a northward shift of the jet stream, based on climate reanalysis data and numerical model experiments

A study utilizing unsupervised deep learning to generate interpretable brain imaging phenotypes from brain T1 and T2-FLAIR MRI identified 97 genetic loci enhancing understanding of brain structure genetics.

A graphene based quasi-solid state rechargeable Li-O₂ battery is developed by utilizing 3D nanoporous graphene cathode, TTF modified quasi-solid state GPE and porous graphene/Li anode. This integrated prototype battery simultaneously addresses the major challenges of Li-O₂ batteries in energy efficiency, lifetime and safety and present an important progress in practical implementation of full performance Li-O₂ battery.