Nature Search

Infectome analysis of small mammals in Southern China reveals pathogen ecology and emerging risks

Less is known about the entire microbial pathogen profile of small mammals. Here, the authors analyse 2,408 tissue-resolved metatranscriptomes to map the infectome in small mammals, uncovering high viral, bacterial, fungal and parasitic diversity and showing how geography, hosts, and seasons shape zoonotic risk.

Genyang Xin
Daxi Wang
Mang Shi
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-13
Retraction Note: DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

Xiao Xiao
Jiankai Liang
Guangmei Yan
Amendments and CorrectionsOpen Access24 Oct 2025
Nature Communications

Volume: 16, P: 1
Peptide codes for organ-selective mRNA delivery

Tissue-specific mRNA or gene editing machinery delivery is achieved with lipid nanoparticles containing peptides with specific sequences, which tune the protein corona of the particles by mechanical optimization of peptide–protein binding affinities.

Tie Chang
Yifan Zheng
Yue Shao
Research01 Sept 2025
Nature Materials

Volume: 25, P: 146-159
Single-Cell-Derived Tumor Organoid (STO) arrays on a microfluidic chip for personalized drug screening to address heterogeneity-induced drug resistance in colorectal cancer

Dongguo Lin
Yanzhang Luo
Dayu Liu
ResearchOpen Access22 Dec 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-14
Author Correction: Highly specific multiplexed RNA imaging in tissues with split-FISH

Jolene Jie Lin Goh
Nigel Chou
Kok Hao Chen
Amendments and Corrections19 Nov 2020
Nature Methods

Volume: 18, P: 114
Author Correction: Highly specific multiplexed RNA imaging in tissues with split-FISH

Jolene Jie Lin Goh
Nigel Chou
Kok Hao Chen
Amendments and Corrections26 Jul 2020
Nature Methods

Volume: 17, P: 947
A cost-effective all-in-one halide material for all-solid-state batteries

A cost-effective all-in-one halide cathode material with high energy density and exceptional cycling stability can be used to achieve energy-dense, durable cathodes for the next generation of all-solid-state batteries.

Jiamin Fu
Changhong Wang
Xueliang Sun
Research25 Jun 2025
Nature

Volume: 643, P: 111-118
Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics

Tracing cellular changes in complex biological systems is challenging. Here, authors present a flexible framework that integrates multi-sample data with in-house algorithms to infer comparative and spatiotemporal cell-gene patterns, advancing understanding of cellular dynamics.

Shuangsang Fang
Mengyang Xu
Xun Xu
ResearchOpen Access21 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques

Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

Zhichao Lai
Deqiang Kong
Xin Liu
Research28 Apr 2025
Nature Cardiovascular Research

Volume: 4, P: 547-566
Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials

Multi-omics data are readily integrated using quartet reference materials.

Yuanting Zheng
Yaqing Liu
Leming Shi
ResearchOpen Access07 Sept 2023
Nature Biotechnology

Volume: 42, P: 1133-1149
Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses

The authors identify nanobodies from immunized alpaca with broadly neutralizing activity against SARS-CoV-1, SARS-CoV-2 variants, and major sarbecoviruses. One representative nanobody binds to a highly conserved epitope on RBD and protects K18-hACE2 mice from Omicron and Delta infection.

Mingxi Li
Yifei Ren
Linqi Zhang
ResearchOpen Access27 Dec 2022
Nature Communications

Volume: 13, P: 1-17
A stress-induced source of phonon bursts and quasiparticle poisoning

Identifying sources of quasiparticle poisoning is an active problem in superconducting quantum circuits. Here the authors show that the rate of quasiparticle bursts in a cryogenic calorimeter decreases by two orders of magnitude in a low-stress suspended state, suggesting stress as a key mechanism.

Robin Anthony-Petersen
Andreas Biekert
Jianjie Zhang
ResearchOpen Access31 Jul 2024
Nature Communications

Volume: 15, P: 1-8
RETRACTED ARTICLE: DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

Xiao Xiao
Jiankai Liang
Guangmei Yan
ResearchOpen Access18 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum

Myeloid-derived growth factor (MYDGF) is an endoplasmic reticulum protein of therapeutic interest because it promotes tissue repair in a murine model of myocardial infarction. Here the authors present the NMR structure of human MYDGF and attribute function to a set of residues conserved in MYDGFs but not the vanin base domain, which has a similar fold.

Valeriu Bortnov
Marco Tonelli
Deane F. Mosher
ResearchOpen Access09 Dec 2019
Nature Communications

Volume: 10, P: 1-14
Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram

Tangram is a versatile tool for aligning single-cell and single-nucleus RNA-seq data to spatially resolved transcriptomics data using deep learning.

Tommaso Biancalani
Gabriele Scalia
Aviv Regev
ResearchOpen Access28 Oct 2021
Nature Methods

Volume: 18, P: 1352-1362
Attentional priorities drive effects of time pressure on altruistic choice

Forcing people to choose quickly often changes pro-social behavior, but it is unclear why. Here, the authors show that under time pressure, people engage in incomplete information searches biased by concern (or lack thereof) for others, explaining effects often attributed to automatic processing.

Yi Yang Teoh
Ziqing Yao
Cendri A. Hutcherson
ResearchOpen Access15 Jul 2020
Nature Communications

Volume: 11, P: 1-13
Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase

N-Acetylglucosamine derivatives equipped with electrophilic groups and handles for subsequent chemical tagging are useful probes of substrate recognition by O-GlcNAc transferases and enable the capture of transient protein substrates of these enzymes.

Chia-Wei Hu
Matthew Worth
Jiaoyang Jiang
Research23 Oct 2017
Nature Chemical Biology

Volume: 13, P: 1267-1273
Characterization of lower urinary tract dysfunction in a mouse model of amyotrophic lateral sclerosis

Ching-Yi Lin
Alex Nelson
Yu-Shang Lee
ResearchOpen Access09 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses

A resource of >1,500 bacterial reference genomes sheds light on the human gut microbiome.

Yuanqiang Zou
Wenbin Xue
Liang Xiao
ResearchOpen Access04 Feb 2019
Nature Biotechnology

Volume: 37, P: 179-185
Highly specific multiplexed RNA imaging in tissues with split-FISH

Split-FISH leverages a split-probe design to achieve enhanced specificity in multiplexed fluorescence in situ hybridization. Split-FISH reduces background and false positives, enabling transcriptome profiling in uncleared tissues.

Jolene Jie Lin Goh
Nigel Chou
Kok Hao Chen
Research15 Jun 2020
Nature Methods

Volume: 17, P: 689-693
An effective vessel segmentation method using SLOA-HGC

Zerui Liu
Junliang Du
Lixiang Sun
ResearchOpen Access06 Jan 2025
Scientific Reports

Volume: 15, P: 1-22
A photocleavable surfactant for top-down proteomics

A mass-spectrometry-compatible surfactant called Azo effectively solubilizes proteins, is rapidly degraded by ultraviolet irradiation and enables top-down proteomic analysis of membrane proteins.

Kyle A. Brown
Bifan Chen
Ying Ge
Research15 Apr 2019
Nature Methods

Volume: 16, P: 417-420
Low-dimensional wide-bandgap semiconductors for UV photodetectors

UV photodetectors based on low-dimensional wide-bandgap semiconductors offer wearable, multidimensional and intelligent functions in the scenarios of imaging, communication, multispectral and/or weak light detection and flexible electronics. This Review focuses on the material design, dimensionality engineering and device engineering of wide-bandgap semiconductors in diversified UV applications.

Ziqing Li
Tingting Yan
Xiaosheng Fang
Reviews18 Aug 2023
Nature Reviews Materials

Volume: 8, P: 587-603
SPOP/NOLC1/B4GALT1 signaling axis enhances paclitaxel resistance in endometrial cancer by inducing O-dysglycosylation

Fengguang Zhai
Yuxuan Li
Xiaofeng Jin
Research17 Mar 2025
Oncogene

Volume: 44, P: 1694-1708
Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC

Jiayu Zhang
Ying Liu
Wenbo Zhu
Research21 Jun 2021
Oncogene

Volume: 40, P: 4783-4795
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

The Consortium for Top-Down Proteomics presents a decision-tree-based guide to sample preparation and analysis protocols for researchers performing top-down mass-spectrometry-based analysis of intact proteins.

Daniel P. Donnelly
Catherine M. Rawlins
Jeffrey N. Agar
ReviewsOpen Access27 Jun 2019
Nature Methods

Volume: 16, P: 587-594
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding

Xiaohua Tang
Rui Sun
Tiannan Guo
ResearchOpen Access25 Jul 2022
Cell Discovery

Volume: 8, P: 1-18
Overexpression of tripartite motif-containing 47 (TRIM47) confers sensitivity to PARP inhibition via ubiquitylation of BRCA1 in triple negative breast cancer cells

Fengen Liu
Binhui Xie
Heping Li
ResearchOpen Access11 Mar 2023
Oncogenesis

Volume: 12, P: 1-12
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity

Wenwei Luo
Jingyan Li
Zhuoming Li
ResearchOpen Access26 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-13
PP2A-B′ holoenzyme substrate recognition, regulation and role in cytokinesis

Cheng-Guo Wu
Hui Chen
Yongna Xing
ResearchOpen Access08 Aug 2017
Cell Discovery

Volume: 3, P: 1-19

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