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A microwave-assisted process is developed for the rapid and scalable manufacture of pure-phase metallic MoS₂ nanosheets, enabling practical electrochemical devices for energy applications.

Phospholipid remodeling governs cell fate, yet its ferroptosis-related mechanisms remain elusive. Here, we report the cryo-EM structure of phospholipid remodeler TMEM164, identify its lipid remodeling mechanism, and discover Montelukast S- enantiomer as a potent inhibitor.

A photocontrol dynamic water gate evaporator with light-adaptive dynamic salt discharge was developed in this study to solve the problem of salt crystallization on the solar evaporator’s surface, which achieves efficient evaporation and salt discharge.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Addressing the stability challenges from metal electrodes/perovskite components chemical interactions is essential for high-performance perovskite solar cells. Here, authors design a bilayer polymer buffer to mitigate metal/ion interdiffusion, realizing a certified efficiency of 26.46%.

This study presents an optical cloud computing system that enables long-distance, high-speed AI processing and communication with low power consumption. The approach offers a scalable and secure alternative to electronic cloud computing, addressing key energy and privacy challenges.

Detailed mechanistic study is challenging but meanwhile benefits rational design of electrocatalysts. Here the authors report bimetallic phosphide for bifunctional hydrazine oxidation and hydrogen evolution reaction and reveal hydrazine oxidation pathways as well as the recovery of metal phosphide active site by N₂H₄ molecules.

The electrocatalytic reduction of CO₂ to high-value products through local coordination environment regulation of metal centers is important. Here, the authors demonstrate an asymmetric Zn-Sn dual atom sites catalyst with d-p orbital hybridization thereby achieving high formate selectivity.

By incorporating electron-withdrawing trifluoroacetate anions into 3D perovskites, Li et al. report retarded Auger recombination due to a decoupled electron-hole wavefunction at the interface and balanced carrier injection from dense film coverage, enabling NIR LEDs with peak efficiency of 21.45% and radiance of 2409 W sr⁻¹ m⁻².

A synergistic approach for uranium extraction, a rechargeable microelectrode adsorbent system, integrates the functions of adsorption and electrochemical reduction, leading to an excellent extraction rate and high adsorption capacity.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

The unique structure and mechanism of chanoclavine synthase (EasC), a haem catalase that uses superoxide for substrate transformation in ergot alkaloid biosynthesis, are revealed in this study, challenging established catalase mechanisms.

Stimulating endogenous cardiomyocyte proliferation offers a promising approach for treating cardiac injuries. Here, the authors demonstrate that Foxk1 and Foxk2 promote heart regeneration by enhancing cardiomyocyte proliferation through cell cycle activation and metabolic reprogramming, presenting potential therapeutic targets for ischemic heart disease

Deep wound healing faces challenges due to poor drug penetration and uncoordinated repair processes. Here, the authors show that stem cell secretome micromotors actively penetrate wounds, accelerating healing by enhancing tissue regeneration and reducing inflammation across species.

In chemical-genetic and lipidomics analyses, the clinical candidate oncology drug tegavivint induced an unconventional form of nonapoptotic cell death that required the lipid metabolic enzyme trans-2,3-enoyl-CoA reductase.

The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, and LTR5Hs inactivation abrogates human PGC specification

RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.

Nautilus, the sole surviving externally shelled cephalopod from the Palaeozoic, holds an important phylogenetic position to understand the evolution of cephalopods. A complete genome of Nautilus pompilius sheds light on the evolution of the pinhole eye and biomineralization.

Human proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce viral infectivity. Here, the authors show that SERINC3 has architecture resembling non-ATP dependent lipid transporters and induces loss of membrane asymmetry correlated with changes in envelope conformation and loss of infectivity.

This study reveals ABA-triggered low-nanomolar Ca²⁺ dynamics in diverse plant organs and cell types using an ultrasensitive Ca²⁺ biosensor. Spatiotemporal Ca²⁺ dynamics modulate the root cap cycle in adaptation to stress through ABA–Ca²⁺–CPK signalling.

The GREGoR consortium provides foundational resources and substrates for the future of rare disease genomics.

Designing bio-inspired artificial neurons within a single device is challenging. Here, the authors demonstrate a spintronic neuron with leaky-integrate-fire and self-reset characteristics and corroborate a new trajectory of all-spin neuromorphic computing hardware holistic implementation.

Nonreciprocal devices are crucial in scientific research and practical applications at all frequencies. Here the authors demonstrate an integrated terahertz optical isolator based on the magneto-optical effect in a nonreciprocal resonator.

Self-sufficient cytochrome P450 monooxygenases, which contain all redox partners in a single polypeptide chain, are of interest for biotechnological applications. Here, the authors present the crystal structure of full-length Thermobispora bispora CYP116B46 and discuss the potential electron transfer pathway.

The antiparasitic drug suramin directly inhibits SARS-CoV-2 RNA-dependent RNA polymerase by blocking binding of the RNA template–primer duplex and entry of nucleotide triphosphate to the catalytic site.

Ruggeri et al. find in a study of 61 countries that temporal discounting patterns are globally generalizable. Worse financial environments, greater inequality and high inflation are associated with extreme or inconsistent long-term decisions.

Wang et al. report large nonvolatile polarization in stretchable polymer ferroelectrics incorporating perovskite nanocrystals. The built-in electric field from poled ferroelectrics stabilises Frenkel defects via interfacial coupling, which can also enhance the polarization of nonferroelectrics.

Stacked elastomeric arrays containing plasmonic nanoparticles show efficient chiral responses that can be fully controlled by mechanical compression and stack rotation. These simple layered materials may be useful modulators for photonic applications.

During zygotic genome activation the embryo must re-wire the regulatory network that sustains totipotency earlier during development. Here they identify ZFP352 as an essential factor that targets retrotransposon families to facilitate dissolution of the totipotency network and enable ZGA.

It is unknown how GPR161, an orphan receptor involved in Hedgehog signaling, is activated. This study identifies a sterol that promotes GPR161-driven cAMP signaling but shows that cAMP is dispensable for Hedgehog pathway repression.

Sun et al. uncover a conserved mechanism by which ribosomes function in defining the position of pachytene piRNA formation on long single-stranded RNAs during spermatogenesis.

The COVID-19 pandemic sparked the need for international collaboration in using clinical data for rapid development of diagnosis and treatment methods. But the sensitive nature of medical data requires special care and ideally potentially sensitive data would not leave the organization which collected it. Xiang Bai and colleagues present a privacy-preserving AI framework for CT-based COVID-19 diagnosis and demonstrate it on data from 23 hospitals in China and the United Kingdom.

In two patient-derived xenograft models of colorectal cancer and a mouse model of autochthonous soft-tissue sarcoma, dietary restriction of methionine influences the outcome of cancer and interacts with antimetabolite and radiation therapies, through effects on one-carbon metabolism.

In a large multi-cancer cohort, a single liquid biopsy assay enables the detection of four epigenomic modifications, allowing the monitoring of expression of potential drug targets and resistance genes.

Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.

A thermoresponsive coacervate enabling the sustained release of micelles and siRNA was developed using an appropriate blend of ABA/AB block copolymers. At room temperature, siRNA-loaded polyion complex (PIC) micelles were dispersed in solution. Upon mild heating ( ≈ 45 °C), they assembled into coacervate microparticles through a reversible phase transition. When maintained at 37 °C, the coacervates continuously and constantly release siRNA and micelles. Biological activities were evaluated using living cells, and cellular uptake and gene knockdown effects were confirmed. This concept highlights a coacervate-based depot platform for siRNA delivery system.