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A cell’s lineage describes the developmental history of a cell from its birth until its final division and differentiation into a particular cell type, which is known as its cell fate. Cell fate is determined by the actions of numerous cell intrinsic and extrinsic factors.
Here authors demonstrate embryonic disruption of Notch signaling impairs the development of specific inhibitory neuron subtypes, leading to autism-like behaviors. Modulating aberrant Notch activity restores circuit balance and behavior.
Dysregulation of H3K4 methylation is associated with neurodevelopmental disorders. Here, the authors perturb H3K4 methylation in the MGE and hypothalamus, resulting in altered gene expression and cell fate as well as changes in behavior that mimic NDD symptoms.
The authors find that distinct radial glia subtypes generate and support midbrain dopaminergic neurons, revealing specialized function and lineage relationships among the diverse cell types that shape dopamine neuron development.
Two parallel transcription cascades via Irx1 and Tbx20, which are downstream of Tbr2, regulate ipRGC subtype formation, fate divergence, and maintenance in the retina.
Pcm1 bridges centrosome asymmetry and polarized endosome trafficking to regulate radial glia progenitor fate decisions, balancing self-renewal and differentiation in zebrafish and human cortical organoids.
We present a developmental atlas that offers insight into sequential epigenetic changes underlying early human brain development modeled in organoids, which reconstructs the differentiation trajectories of all major CNS regions. It shows that epigenetic regulation via the installation of activating histone marks precedes activation of groups of neuronal genes.
We discovered expression of SYNGAP1, which encodes the ‘synaptic’ protein SYNGAP1, within human cortical progenitors. In an organoid model of SYNGAP1 haploinsufficiency, cortical neurogenesis and neuronal network activity were disrupted. This finding reveals an unknown function for SYNGAP1 at early stages of development, providing a new framework for understanding the pathophysiology of autism spectrum disorder.
A new technique developed by Garcia-Marques and colleagues uses CRISPR–Cas9 editing to activate an ordered sequence of fluorescent markers in stem cells and their progeny. These tools represent a new way to probe the spatial and temporal patterns of cell lineage progression.
A study in Nature describes RNA velocity, which is a computational method to derive dynamic gene expression information from static single-cell RNA sequencing data. It provides valuable insights into developmental trajectories of cells.
