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Micro-ultrasound in prostate cancer screening: bridging the gap between acoustic resolution and clinical certainty

Prostate Cancer and Prostatic Diseases (2026)Cite this article

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To the Editor:

The PROSTAMUS study provides a compelling exploration of 29 MHz micro-ultrasound (MUS) as a potentially transformative tool in the landscape of opportunistic prostate cancer screening [1]. By integrating high-resolution imaging with PSA density, the authors present a pathway that could significantly refine risk stratification. However, as clinicians and data scientists, we believe several nuanced methodological considerations regarding verification, physics, and spatial precision warrant further discussion to ensure these findings can be robustly translated into high-volume clinical practice.

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Fig. 1: The verification iceberg and simulated diagnostic migration.

References

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Authors and Affiliations

  1. Urology of Shenzhen Longgang Central Hospital, Shenzhen, China

    Zuomin Wang, Qinwei Liu & Wangdong Deng

Authors
  1. Zuomin Wang
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  2. Qinwei Liu
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  3. Wangdong Deng
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Contributions

QL and WD contributed equally to the conception and design of the study. ZW conducted the literature search, data collection, and analysis. QL assisted in the interpretation of findings and critically revised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Wangdong Deng.

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Wang, Z., Liu, Q. & Deng, W. Micro-ultrasound in prostate cancer screening: bridging the gap between acoustic resolution and clinical certainty. Prostate Cancer Prostatic Dis (2026). https://doi.org/10.1038/s41391-026-01102-x

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