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This study reveals that processing negative words in pun-humor sentences elicits mixed feelings, in which neural representations of negativity and amusement coexist within a shared temporal window, demonstrating the highly simultaneous pattern.
This study demonstrates that deep recurrent neural networks outperform other models (e.g., CNNs, Transformers) in capturing auditory cortex activity across species. It also introduces an automated tool to extract spatio-temporal receptive fields (STRFs) for each neural unit.
Kinematic analyses of Lake Malawi cichlids reveal that algae specialists use head expansions that happen synchronously along the head. This contrasts with the wave-like pattern of piscivores and is hypothesized to increase algae feeding efficiency.
Immediate-early genes Arc and c-Fos label more divergent populations in the mouse brain than previously thought, across several brain regions during contextual fear encoding and retrieval.
Early life is a critical window for immune development, marked by shifts in cell composition and function. Age and sex influence this process and are associated with epigenetic differences in immune-related DNA methylation, based on analysis of whole blood samples collected at ages 1 vs. 5 from a Canadian longitudinal paediatric cohort
Modelling cardiomyocyte geometry reveals that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism.
HSPA4 mitigates ferroptosis in Parkinson’s disease models by binding transferrin and preventing iron uptake, protecting dopaminergic neurons and improving motor function, suggesting its potential as a therapeutic target.
The Human Cell Aging Transcriptome Atlas contains single cell RNA-sequencing data from 3,475 human samples and interactive tools to explore age-related alterations in gene expression and go term enrichment in a diverse set of tissues and cell types.
Kidney-resident Cxcl9high macrophages in lupus nephritis mice drive disease progression by recruiting circulating Cxcr3+ plasmablasts into kidneys, where the latter differentiate into long-lived plasma cells and secrete antibodies.
Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.
The cryo-EM structure of the receptor binding domain of Microcin V in complex with its bacterial receptor, Cir, demonstrates a conserved bacteriocin/receptor interaction and illuminates a potential path for future drug development.
Tizoxanide is identified as an anti-virulence compound against Erwinia amylovora that inhibits virulence factors and alters metabolic proteins. It protects apple seedlings effectively, and an isoxazole derivative shows enhanced efficacy.
The spatiotemporal dynamics of neural processes revealed by human intracranial recordings sheds light on the temporal order of computations in speech production.
This review outlines how mammalian cells adapt to cold via ion channels, uncoupling proteins, epigenetic changes, and RNA-binding proteins, with insights from hibernators highlighting therapeutic potential in metabolism and neuroprotection.
Functional mapping of cortical asymmetry across seven fMRI tasks shows that asymmetry and bilateral brain activation are positively associated, with bilateral activation being a stronger predictor of task accuracy.
Iron diminishes the antifungal efficacy of caspofungin against Candida albicans by binding the drug and inducing conformational changes that impair β-1,3-D-glucan synthase inhibition.
This study provides evidence on how carbon metabolism regulates cell division among cyanobacteria. Manipulation of the TCA pathway directly impacts the FtsZ-dependent cell division by regulating its expression via the transcriptional factor NtcA.
The level of β-OHB markedly enhances kbhb of hippocampal CaMKII-α at the K42 and K267 residues, which suppresses CaMKII activity, leading to memory impairment in T1DM mice.
ConSTRain is a short tandem repeat caller allowing for the investigation of tumour heterogeneity and clonal lineage tracing in cancer, even in closely related samples.
