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In this study, the authors describe SANA, a nitroalkene derivative of salicylate, as a potential activator of creatine-dependent energy expenditure and thermogenesis in adipose tissue. Preclinical and clinical data from this paper also suggest that SANA improves glucose homeostasis and promotes weight loss in mice and humans.
The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.
In this paper, the authors describe the energy state-dependent regulation of the PVNGLP-1R to DVC circuit, resulting in altered food intake and metabolic health, mediated by GLP-1 receptor signalling.
The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
A ketogenic diet and the ketone body β-hydroxybutyrate are shown to confer resistance to malaria in mice by inducing metabolic reprogramming in Plasmodium parasites, suggesting a dietary strategy for malaria prevention.
Nuclear SREBP2 forms nuclear condensates through its N-terminal intrinsically disordered region, which is essential for the transcriptional activation of lipogenic genes.
Tsyben et al. study the spatial distribution of labelled metabolites in glioblastoma samples from patients infused with 13C-glucose, using mass spectrometry imaging.
Kao et al. provide insight into the metabolic requirements of IL-17A-producing γδ T cells, offering an actionable target to treat psoriasis by inhibiting fatty acid synthesis.
In a prospective, double-blind, randomized, placebo-controlled trial, supplementation with a combination of conventional and gut-targeted nicotinamide was safe and effective in ameliorating COVID-19 symptoms.
The authors provide insights into the role of neuronal CCL2 expression, which is triggered with hyperglycaemia and modulates anxiety disorders under conditions of diabetes.
In this study, Flickinger et al. uncover the essential role of cytosolic NADK and why the relative importance of this role further depends on folate availability.
This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.
This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.
Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.
The authors use single-cell analyses to demonstrate the spatiotemporal plasticity of hepatocyte gluconeogenesis, highlighting the complexity of hepatic glucose homeostasis across states of feeding, fasting and starvation.
Toledo et al. show that metabolic hormones acting in the hypothalamus, along with direct manipulation of hypothalamic neurons, can drive remodelling of microbial communities in the gut within short periods of time.
Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the type I interferon production.
In Drosophila and mouse models of cancer cachexia, Liu et al. show that tumour-derived cytokines induce hepatic gluconeogenesis, which in turn leads to dysregulation of metabolism and drives cancer cachexia.
