Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Articles in 2025

Filter By:

  • Wildfires emit carcinogenic pollutants, raising long-term cancer risks in affected populations. In this Comment, Weichenthal highlights these concerns and outlines actionable solutions to reduce exposure and mitigate risks.

    • Scott Weichenthal
    Comment
  • Yang et al. developed a proteolysis-targeting chimera (PROTAC) 753b, which targets BCL-xL and BCL-2 to the E3 ubiquitin ligase VHL, and showed that it removed senescent cells specifically from the liver, reducing the progression of chronic metabolic liver disease to liver cancer.

    • Anna Dart
    Research Highlight
  • In this Review, Bruhm et al. provide a comprehensive overview of targeted and genome-wide cell-free DNA detection approaches, examining their potential to complement existing screening programmes or enhance early cancer detection for those cancers without effective screening methods.

    • Daniel C. Bruhm
    • Nicholas A. Vulpescu
    • Victor E. Velculescu
    Review Article
  • While cancer treatments are essential for patient survival, they often induce premature ageing-related conditions in survivors. In this Comment, Demaria outlines how understanding the underlying molecular mechanisms of this is crucial for developing integrated strategies to improve long-term health outcomes in survivors.

    • Marco Demaria
    Comment
  • In this Tool of the Trade article, Tim Coorens describes the development of SComatic, an algorithm enabling the detection of somatic mutations in single-cell RNA- or ATAC-sequencing data, and its use to study lineage relations and mutational signatures.

    • Tim H. H. Coorens
    Tools of the Trade
  • While progress has been made in treating advanced non-small-cell lung cancer, patients would further benefit from methods that detect progressive premalignant lesions and strategies that effectively intercept progression. In this Review, Mazzilli et al. explore recent advances in identifying premalignant lesions, highlighting their disease aetiology and devising approaches for stratification and interventions aimed at halting the progression to cancer.

    • Sarah A. Mazzilli
    • Zahraa Rahal
    • Avrum E. Spira
    Review Article
  • In this Expert Recommendation, Holowatyj et al. cover the current state of the field in appendiceal cancer, including the distinct challenges involved in studying this rare tumour type, and propose a conceptual research framework to facilitate discoveries that will advance knowledge of appendix carcinogenesis and metastasis to deliver better outcomes for patients.

    • Andreana N. Holowatyj
    • Michael J. Overman
    • Deborah Shelton
    Expert Recommendation
  • Dendritic cells (DCs) shape the adaptive immune response to peripheral tissue antigens and, as such, are crucial for mounting an effective antitumour immune response in cancer. This Review outlines the molecular basis of DC maturation, highlights the mechanisms through which cancer impairs DC maturation and considers the potential for DC-focused cancer immunotherapeutics.

    • Chang Yoon Moon
    • Meriem Belabed
    • Miriam Merad
    Review Article
  • In this study, Alexander et al. find that HIF2α regulates speckle–DNA associations to fine-tune the expression of a subset of its target genes, and demonstrate that speckle phenotypes correlate with outcomes in renal cell carcinoma.

    • Daniela Senft
    Research Highlight
  • Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz and Atherton highlight comparative oncology successes, emphasizing the need for broader application of findings from canine studies to improve human cancer treatments.

    • Jennifer A. Lenz
    • Matthew J. Atherton
    Comment
  • Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, Son et al. find that commensal papillomavirus maintains homeostasis in sun-damaged skin.

    • Gabrielle Brewer
    Research Highlight
  • In this Review, Luri-Rey et al. present evidence for the crucial role of conventional type 1 dendritic cells in cross-presenting antigens from other cells via the major histocompatibility complex class I antigen-presenting machinery, which in turn is necessary to prime CD8+ T cells, which then mount efficient immune responses against cancer. The authors also discuss how we can exploit these processes in cancer immunotherapy by increasing the number and/or maturation or activation status of this specialist subtype of antigen-presenting cell.

    • Carlos Luri-Rey
    • Álvaro Teijeira
    • Ignacio Melero
    Review Article
  • In this Review, Suvac et al. discuss how intratumoural hypoxia is a driving force in tumour evolution, alongside driver gene mutations, through the generation of genomic instability. The resultant selected unstable tumour clones underpin resistance to local and systemic therapies and unfavourable outcomes for patients with cancer.

    • Alexandru Suvac
    • Jack Ashton
    • Robert G. Bristow
    Review Article
  • In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment that drives cancer progression. They explore how this crosstalk impacts on metastasis, inflammation and cachexia, providing insights for enhanced cancer management.

    • Patricia Altea-Manzano
    • Amanda Decker-Farrell
    • Ayelet Erez
    Review Article
  • In a recent study published in Nature, Zhuang et al. outline how ageing affects stemness and tumorigenic potential of tumour-initiating alveolar stem cells in the lung.

    • Gabrielle Brewer
    Research Highlight
  • Genomic mutations can be translated into modified functional proteins, impacting protein–protein interactions (PPIs) and thus altering cellular functions. In this Review, Fu, Mo and Ivanov summarize the mechanisms by which oncogenic mutations impact PPIs, technologies for monitoring this, the categories and features of PPIs in cancer, and finally the therapeutic implications of this.

    • Haian Fu
    • Xiulei Mo
    • Andrey A. Ivanov
    Review Article
  • The mechanisms by which dietary fructose promotes tumour progression have remained poorly understood. A recent study published in Nature reveals that dietary fructose is metabolized in the liver, resulting in elevated circulating lipid levels that can serve as building blocks for cancer cells outside the liver.

    • Daniela Senft
    Research Highlight

Search

Quick links