Nature Search

Clones of helper T cells mediate antigen-specific, H–2-restricted DTH

A. T. J. Bianchi
H. Hooijkaas
M. H. Schreier
Research01 Mar 1981
Nature

Volume: 290, P: 62-63
Migration and hominid bipedalism

A.R.E. SINCLAIR
MARY D. LEAKEY
M. NORTON-GRIFFITHS
Research01 Nov 1986
Nature

Volume: 324, P: 307-308
Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

Chikungunya virus infection leads to painful arthritis-like joint inflammation. This study shows that the NLRP3 inflammasome is crucial for alphavirus-induced inflammation and its inhibition is an effective therapeutic strategy.

Weiqiang Chen
Suan-Sin Foo
Suresh Mahalingam
Research28 Aug 2017
Nature Microbiology

Volume: 2, P: 1435-1445
Artificial intelligence detects awareness of functional relation with the environment in 3 month old babies

Massoud Khodadadzadeh
Aliza T. Sloan
J. A. Scott Kelso
ResearchOpen Access06 Jul 2024
Scientific Reports

Volume: 14, P: 1-19
Flow-enhanced vascularization and maturation of kidney organoids in vitro

Culturing human kidney organoids under fluidic shear conditions leads to robust vascularization and increased maturity. These kidney organoids should serve as a better model for kidney development than those developed in static culture.

Kimberly A. Homan
Navin Gupta
Ryuji Morizane
Research11 Feb 2019
Nature Methods

Volume: 16, P: 255-262
Some Relationships between Morphology and Antigenic Structure in Bacteria

K. A. BISSET
Research20 Jun 1953
Nature

Volume: 171, P: 1118-1119
Dopamine signaling drives skin invasion by human-infective nematodes

Skin-penetrating nematodes infect hosts by burrowing through host skin. This study finds that in the human-parasitic, skin-penetrating nematode Strongyloides stercoralis, skin penetration behavior is controlled by dopaminergic signaling.

Ruhi Patel
Gloria Bartolo
Elissa A. Hallem
ResearchOpen Access13 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Eclipse Flight of Concorde 001

J. BECKMAN
J. BEGOT
P. WRAIGHT
Research09 Nov 1973
Nature

Volume: 246, P: 72-74
Specificity of the Interactions Between Histones and Deoxyribonucleic Acid

E. W. JOHNS
J. A. V. BUTLER
Research28 Nov 1964
Nature

Volume: 204, P: 853-855
School Laboratory Plans

A. E. MUNBY
Research06 Jul 1899
Nature

Volume: 60, P: 222
Three forms of delayed skin-test response evoked by mycobacteria

G. A. W. ROOK
Research01 Jan 1978
Nature

Volume: 271, P: 64-65
Response to stress of mesocortico-frontal dopaminergic neurones in rats after long-term isolation

G. Blanc
D. Hervé
J. P. Tassin
Research20 Mar 1980
Nature

Volume: 284, P: 265-267
Porpoises and the Bow-Riding of Ships Under Way

ANDREW A. FEJER
RICHARD H. BACKUS
Research26 Nov 1960
Nature

Volume: 188, P: 700-703
Structure of the vacuolar-type ATPase from Saccharomyces cerevisiae at 11-Å resolution

Vacuolar-type ATPases (V-type ATPases) are large integral membrane protein complexes. Their activity acidifies intracellular compartments, and they are regulated by the dissociation of the complex's V1 and VO regions. The cryo-EM reconstruction of the yeast V-type ATPase suggests how structural rearrangements triggered by dissociation of V1 leads to inhibition of activity.

Samir Benlekbir
Stephanie A Bueler
John L Rubinstein
Research11 Nov 2012
Nature Structural & Molecular Biology

Volume: 19, P: 1356-1362
“Burtle Clay” of Somerset

A. B. HAWKINS
G. A. KELLAWAY
Research25 May 1973
Nature

Volume: 243, P: 216-217
The Blondlot n-Rays

A. A. CAMPBELL SWINTON
Research03 Mar 1904
Nature

Volume: 69, P: 412
Three Hundred Years of Botany in Edinburgh

J. A. RATTER
Research06 Jun 1970
Nature

Volume: 226, P: 904-907
Virus Isolation in the Zonal Ultracentrifuge

NORMAN G. ANDERSON
Research21 Sept 1963
Nature

Volume: 199, P: 1166-1168
Influence of various legwear during arterial stiffness measurement

Taha A. Alhalimi
Tianyu Wang
Hirofumi Tanaka
Research04 May 2025
Journal of Human Hypertension

Volume: 39, P: 457-461
Basal paravian functional anatomy illuminated by high-detail body outline

Soft tissues are rarely preserved in the fossil record; therefore, body shape of extinct vertebrates is usually inferred indirectly. Here, the authors use laser-stimulated fluorescence of fossils to detect and reconstruct the body outline of the paravian dinosaurAnchiornisfrom the Late Jurassic.

Xiaoli Wang
Michael Pittman
Xing Xu
ResearchOpen Access01 Mar 2017
Nature Communications

Volume: 8, P: 1-6
Open Packing of Spheres

A. S. E. ACKERMANN
Research20 Jan 1945
Nature

Volume: 155, P: 82
Are fast-moving elephants really running?

Despite their unseemly bulk, elephants can hit high speeds — but use an unusual style.

John R. Hutchinson
Dan Famini
Rodger Kram
Research03 Apr 2003
Nature

Volume: 422, P: 493-494
Multiple S-isotopic evidence for episodic shoaling of anoxic water during Late Permian mass extinction

A final catastrophe killed 90% of marine species at the end of the Permian period, but significant biodiversity loss preceded this event. In this study, sulphur isotope evidence suggests that incursion of anoxic water into shallow regions may have contributed to biodiversity loss.

Yanan Shen
James Farquhar
Boswell A. Wing
ResearchOpen Access22 Feb 2011
Nature Communications

Volume: 2, P: 1-5
Bioinspired kirigami metasurfaces as assistive shoe grips

Buckling kirigami structures applied to footwear outsoles generate higher friction forces transversally to the direction of movement.

Sahab Babaee
Simo Pajovic
Giovanni Traverso
Research01 Jun 2020
Nature Biomedical Engineering

Volume: 4, P: 778-786
Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

Glycosylated peptides targeting hepatic antigen-presenting cells induce antigen-specific immune tolerance, preventing T-cell-mediated diabetes in mice.

D. Scott Wilson
Martina Damo
Jeffrey A. Hubbell
Research29 Jul 2019
Nature Biomedical Engineering

Volume: 3, P: 817-829
A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress

Yi-Shuan Sheen
Yi-Hua Liao
Chia-Yu Chu
ResearchOpen Access17 Jul 2017
Scientific Reports

Volume: 7, P: 1-6
Mosaic anatomy in an early fossil squamate

Breugnathair elgolensis gen. et sp. nov., an early squamate identified from a newly discovered Middle Jurassic skeleton on the Isle of Skye, provides new evidence on the origins of snakes.

Roger B. J. Benson
Stig A. Walsh
Susan E. Evans
ResearchOpen Access01 Oct 2025
Nature

Volume: 647, P: 673-679
Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science

The engineering of biomimetic materials is accelerated by combining high-throughput RNA sequencing and proteomics.

Paul A Guerette
Shawn Hoon
Ali Miserez
Research08 Sept 2013
Nature Biotechnology

Volume: 31, P: 908-915
Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration

Miao et al. show that loss of neuronal Vps13d in mice leads to mitochondrial dysfunction, GSDME-mediated mitochondrial DNA release, cGAS–STING inflammatory signaling and activation of microglia, culminating in neuronal loss.

Guangyan Miao
Tina M. Fortier
Eric H. Baehrecke
Research25 Jun 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2046-2059
A postzygotic GNA13 variant upregulates the RHOA/ROCK pathway and alters melanocyte function in a mosaic skin hypopigmentation syndrome

Here, the authors have identified a mutation in the gene GNA13 in patients with hypomelanosis of Ito and developmental anomalies, which triggers excessive RHOA/ROCK signaling and actin polymerization, leading to melanocyte rounding and failure in melanosome transfer to keratinocytes.

Rana El Masri
Alberto Iannuzzo
Jérôme Delon
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-15
The global and regional burden of diabetic peripheral neuropathy

Diabetic peripheral neuropathy (DPN) is length-dependent peripheral nerve damage that frequently arises as a complication of type 1 or type 2 diabetes, and even prediabetes. This Review highlights the global and regional burden of DPN and explores risk factors, including metabolic factors beyond hyperglycaemia, that could guide treatment and prevention strategies.

Masha G. Savelieff
Melissa A. Elafros
Eva L. Feldman
Reviews05 Dec 2024
Nature Reviews Neurology

Volume: 21, P: 17-31
Plethysmometric Measurement of Swelling in the Feet of Small Laboratory Animals

G. A. H. BUTTLE
P. F. D'ARCY
D. N. KELLETT
Research23 Mar 1957
Nature

Volume: 179, P: 629
Targeted neurotechnology restores walking in humans with spinal cord injury

Spatially selective and temporally controlled stimulation of the spinal cord, together with rehabilitation, results in substantial restoration of locomotor function in humans with spinal cord injury.

Fabien B. Wagner
Jean-Baptiste Mignardot
Grégoire Courtine
Research31 Oct 2018
Nature

Volume: 563, P: 65-71
An implantable system to restore hemodynamic stability after spinal cord injury

A purpose-built implantable system based on biomimetic epidural electrical stimulation of the spinal cord reduces the severity of hypotensive complications in people with spinal cord injury and improves quality of life.

Aaron A. Phillips
Aasta P. Gandhi
Grégoire Courtine
ResearchOpen Access17 Sept 2025
Nature Medicine

Volume: 31, P: 2946-2957
Rescue of GABA_B and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice

Dysregulated GABA-GIRK signaling drives lateral habenula hyperactivity in mouse models of depression. Restoring GABA-GIRK signaling by treatment with a PP2A inhibitor alleviates depression-like phenotypes.

Salvatore Lecca
Assunta Pelosi
Manuel Mameli
Research25 Jan 2016
Nature Medicine

Volume: 22, P: 254-261
Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions

Mucus are ubiquitous natural materials, but little is known about their structures or properties. Here, the authors identify the components of three functional mucus from snails, which are the focus of a rapidly growing number of biomedical and cosmetic applications.

Antonio R. Cerullo
Maxwell B. McDermott
Adam B. Braunschweig
ResearchOpen Access02 Sept 2023
Nature Communications

Volume: 14, P: 1-14
Neanderthal coasteering and the first Portuguese hominin tracksites

Carlos Neto de Carvalho
Pedro Proença Cunha
Clive Finlayson
ResearchOpen Access03 Jul 2025
Scientific Reports

Volume: 15, P: 1-25
Transient modeling and performance evaluation of a solar-driven HDH desalination system with phase change material storage

Suleiman Ibrahim Mohammad
Muhammad Jawad
Morteza Aladdin
ResearchOpen Access03 Feb 2026
Scientific Reports

Volume: 16, P: 1-20
All-cause hospital admissions and incidence of type 2 diabetes among adolescents in Kazakhstan

Kuralay Atageldiyeva
Dmitriy Syssoyev
Dinara Galiyeva
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Estimation of joint torque in dynamic activities using wearable A-mode ultrasound

Monitoring internal loads in the human musculoskeletal system has been challenging, especially during dynamic movement. Here, the authors present a wearable joint torque estimation strategy using A-mode ultrasound and demonstrate its effectiveness during various real-world activities.

Yichu Jin
Jonathan T. Alvarez
Conor J. Walsh
ResearchOpen Access09 Jul 2024
Nature Communications

Volume: 15, P: 1-12
HDAC2 negatively regulates memory formation and synaptic plasticity

Histone acetylation has been implicated in learning and memory. Neuron-specific overexpression of histone deacetylase 2 (HDAC2), but not HDAC1, is shown to decrease memory formation in a rodent model. This encourages development and testing of HDAC2-selective inhibitors for human diseases associated with memory impairment.

Ji-Song Guan
Stephen J. Haggarty
Li-Huei Tsai
Research07 May 2009
Nature

Volume: 459, P: 55-60
Rapid and accurate measurement of growth of solid tumours and changes in the tumour bed in the rat by the technique of volumetric displacement

H A Van Den Brenk
M G Stone
M C Crowe
Research01 Jan 1977
British Journal of Cancer

Volume: 35, P: 92-99
Sorafenib plus selective internal radiotherapy with ⁹⁰Y resin microspheres for the treatment of uveal melanoma with liver metastasis: a phase I trial

Grégoire Berthod
Christophe Cisarovsky
Serge Leyvraz
ResearchOpen Access11 Dec 2025
British Journal of Cancer

Volume: 134, P: 589-597
Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke

Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural progenitors, thus improving outcomes after stroke.

Wenlu Li
Emiri T. Mandeville
Eng H. Lo
ResearchOpen Access19 Dec 2022
Nature Communications

Volume: 13, P: 1-14
Detection of Water in Interstellar Regions by its Microwave Radiation

A report of the detection of microwave radiation from water molecules in space, by the group which recently detected interstellar ammonia emission.

A. C. CHEUNG
D. M. RANK
W. J. WELCH
Research15 Feb 1969
Nature

Volume: 221, P: 626-628
Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy

Injectable hydrogels are being explored for Rheumatoid Arthritis (RA) therapy, but most existing injectable hydrogels address only specific aspects of the RA pathological microenvironment. Here, the authors report an injectable bioadhesive and lubricating hydrogel, that prevents cartilage wear, provides long-term anti-inflammatory effects, and repairs damaged cartilage for RA therapy.

Huan He
Qin Zhang
Chaoming Xie
ResearchOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Nuclear entry of AS160 as a transcriptional regulator of satellite cells for muscle regeneration

The mechanisms resulting in muscle satellite cell dysfunction in diabetes are not well understood. Here, the authors show that AS160 functions in the nucleus to regulate satellite cell proliferation and that its impaired nuclear entry is linked to diabetic myopathy.

Xinyu Yang
Ye Cao
Shuai Chen
ResearchOpen Access15 Oct 2025
Nature Communications

Volume: 16, P: 1-19
Aging effects on the mechanical energy transfer through the lower extremity joints during the swing phase of level walking

Hung-Bin Chen
Liang-Wey Chang
Chih-Hsiu Cheng
ResearchOpen Access02 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

Rapidly progressive glomerulonephritis (RPGN) is a form of severe kidney injury that can lead to promptly lethal renal failure. Pierre-Louis Tharaux and colleagues report that HB-EGF is upregulated in RPGN, resulting in activation of EGFR in podocytes and their dysfunction. They further show that genetic loss of expression of HB-EGF or EGFR in a mouse model is protective, whereas pharmacological inhibition of EGFR, even after disease onset, is therapeutic. These results suggest a possible avenue of treatment for this potentially devastating condition.

Guillaume Bollée
Martin Flamant
Pierre-Louis Tharaux
Research25 Sept 2011
Nature Medicine

Volume: 17, P: 1242-1250
AKT2 is essential to maintain podocyte viability and function during chronic kidney disease

Rapamycin (also known as sirolimus) is a potent immunosuppressive drug that is often used after organ transplant to prevent rejection, but it also can cause kidney dysfunction. Fabiola Terzi and her colleagues now show this side effect of rapamycin is due to targeting of mTORC2 and suppression of AKT2 activity in podocytes. They also show that AKT2 normally acts to maintain podocyte viability and structure during chronic kidney disease.

Guillaume Canaud
Frank Bienaimé
Fabiola Terzi
Research22 Sept 2013
Nature Medicine

Volume: 19, P: 1288-1296

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