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The alignment of heterogeneous spatial samples has become a growing challenge. Here, authors present a multi-scale, multi-context, and interpretable mapping strategy to map cells across space, time, and disease.

CytoSPACE maps individual cells from a reference single-cell RNA sequencing atlas to spatial transcriptomics data.

Using single-cell imaging of the cyanobacterium Synechococcus, the authors show that confinement or mechanical perturbations result in altered photosynthetic activity.

Control of the electron spin as well as its charge is predicted to lead to efficient electronic devices, with potentially new functionalities. Injecting and manipulating spin-polarized carriers in silicon is a natural step towards integrating spintronics with current technology. This Review describes the first encouraging results as well as the open questions and challenges that still remain.

Polyamines are essential metabolites linked to aging, cancer, and Parkinson’s disease. Here, authors develop a live-cell polyamine reporter and use a genome-wide CRISPR screen to uncover a link between mitochondrial respiration and polyamine import.

Harnessing spin angular momentum could allow the development of electronic devices that are not limited by Moore's law. Here, electrical injection and detection of spin accumulation is achieved at temperatures that are practical for device operation.

Wang, Wilfahrt and colleagues show that phosphoethanolamine, a phospholipid intermediate, is enriched in tumour interstitial fluid and induces T cell dysfunction, in part by depleting diacylglycerol and dampening T cell receptor signalling.

Spin can be injected into silicon from a ferromagnetic contact and across a graphene barrier with resistance-area products up to one thousand times lower than with comparable oxide tunnel barriers.

Observations of a fast X-ray transient reveal that it is a gamma-ray-burst explosion from a very distant galaxy that emits light with the wavelength necessary to drive cosmic reionization, the last major phase change in the history of the Universe.

α-Synuclein accumulation in putaminal synapses is hypothesised to drive Parkinson’s disease progression. This study demonstrates synaptic pSer129 α-synuclein enrichment in early-stage Parkinson’s disease, and its link with dopaminergic denervation and cortical Lewy body pathology.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

A screen of nutrient-derived compounds identified trans-vaccenic acid as a promoter of effector T cell function, and functional assays demonstrate that this occurs via inactivation of GPR43 on T cells.

Organic polymer nanomechanics has been explored through precise nanometre-scale stiffness measurements in a high-mobility semiconducting polymer. Higher eigen-mode atomic force microscopy is used to measure nanomechnical variations in the film texture, as well as the nanoscale order in the material.

An exchange bias phenomenon not present in bulk ferromagnetic systems is now observed at the Fe/MgO interface.

Graphene forms low-resistance tunnel barriers for spin injection from a ferromagnet into silicon. Here, the authors fabricate silicon nanowire non-local spin valves with graphene tunnel barriers, evidencing spin accumulation and transport via Hanle spin precession measurements.

Here, the authors report the observation of an interlayer plasmon polaron in heterostructures composed of graphene and monolayer WS₂. This is manifested in the ARPES spectra as a strong quasiparticle peak accompanied by several carrier density-dependent shake-off replicas around the WS₂ conduction band minimum.

Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4⁺ T cells, in asthmatic lungs

Early emission from gamma-ray burst GRB 211211A comes entirely from charged particles accelerating in strong magnetic fields. The fast-evolving spectrum may be the key to understanding unusually long-lived GRBs from neutron star mergers.

The spin-momentum locking in a topological insulator can be detected directly through electrical measurements.

This paper presents evidence for dynamical interactions in the very dense regions in the core of galaxies causing two compact objects, such as neutron stars and black holes, to merge, leading to a gamma-ray burst.

A microfocused angle-resolved photoemission spectroscopy study of single layers of WS₂ on hexagonal boron nitride reveals that, upon electron doping, trionic interactions cause a giant increase of the spin splitting in the valence band.

Spin-polarized states arising from either Rashba splitting or topological effects are expected to produce current-induced spin polarization with different magnitude and sign. Here, Li et al. observe current-generated spin polarization in both Bi₂Se₃(111) and InAs (001) films, with opposite signs of the spin voltage.

Metastatic pancreatic ductal adenocarcinoma (mPDAC) has limited therapeutic options and is associated with a poor prognosis. Here the authors report the results of a randomized phase II trial showing that combining checkpoint inhibitors (durvalumab and tremelimumab) with chemotherapy (gemcitabine and nab-paclitaxel) does not improve survival compared to chemotherapy alone in patients with mPDAC.

The authors benchmark methods to detect non-linear SNP, gene, and pathway interactions using visible neural networks, validating them on simulations and IBD data, where they identify seven significant epistasis pairs with high method agreement.

Ron Evans and his colleagues have shown that excess thyroid hormone receptor signaling during embryonic development in mice impairs the differentiation of type I pneumocytes, a key lung cell type needed for proper gas exchange. They also show that treatment with antithyroid drugs during this stage of development rescues the defect in lung maturation, suggesting a possible therapy for some children born with respiratory distress syndrome.

Transient object ASASSN-15lh was previously cast as the most luminous supernova ever discovered. Now, however, there is convincing evidence that its flare was a tidal disruption event: a rapidly-spinning black hole tearing apart a neighbouring star.

Here, the authors describe an international consensus procedure for determining freely dissolved concentrations (C_free) of hydrophobic organic chemicals in sediment and soil samples by passive sampling.

Observations of a white dwarf/cool star binary that emits from X-ray to radio wavelengths, AR Sco, reveal a close binary with a 3.56-h period, pulsing in brightness with a period of 1.97 min; these pulses are so intense that the optical flux of AR Sco can increase by a factor of four within 30 s, and the pulsing is detectable at radio frequencies.