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The wide range of properties encountered in metamaterials make them promising for numerous optical applications. Chenet al. build a plasmonic flat metamaterial lens with an abrupt phase change that functions as a convex lens for one handedness of light and a concave lens for the other.

The immunomodulatory functions of mast cells (MCs) within the tumor microenvironment are elusive. Here, the authors present a transcriptomic characterization of LUAD-infiltrating MCs and identify a proinflammatory subset that contributes to the activation of cytotoxic MAIT cells by secreting IL-18 via NRLP3 activation and pyroptosis, ultimately boosting anti-tumor immunity.

Some individuals develop antibodies against the polyethylene glycol that is commonly used in therapeutic preparations. Here the authors conduct a GWAS in Han Chinese and find the IGH locus is associated with anti-PEG IgM.

A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.

Piracetam improves wide-bandgap perovskite crystallinity and uniformity, enabling monolithic all-perovskite tandem solar cells with efficiencies of 28.71% (0.07 cm²) and 28.20% (1.02 cm²), ensuring minimal efficiency loss during scale-up.

A relative potency-adjusted inventory of fine-particulate matter (PM_2.5) established in China reveals sectoral and regional disparities in PM_2.5 emissions, exposures and associated toxic potencies.

Electrochemistry has emerged as an increasingly viable tool in molecular synthesis. Here the authors realize electrocatalyzed C−H activations, with the aid of data science and artificial intelligence, towards selective alkenylations for late-stage drug diversifications.

The sexually transmitted human parasite Trichomonas vaginalis belongs to a clade of host-switching trichomonads that parasitize mammals, birds, livestock, and pets. Here the authors describe a chromosome-scale genome for T. vaginalis and assemblies of other bird and mammal-infecting species, identifying gene functions implicated in the spillover of trichomonads from birds to humans.

Single-atom catalysts emerge as nanocatalytic medicine in chemodynamic therapy but suffer from inefficient kinetics for the production of reactive oxygen species because of the cell’s antioxidative mechanisms. Here, the authors employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatment.

Charge density waves usually cause electrons to become heavier and slow down. Here, the authors find the opposite is true in CuTe and study the phenomenon using advanced q-EELS.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

Combination immunotherapy with anti-PD-1 and anti-LAG-3 antibodies has shown anti-tumor effects across various cancers, however not all patients respond. Here the authors report that resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by the interaction of Sox9+ tumor cells with Frp1+ neutrophils, resulting in impaired anti-tumor immunity.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

Spin-split bands and certain lattice symmetries are required to generate the spin currents needed for spintronics applications. Now a layered room-temperature antiferromagnet is shown to exhibit anisotropic spin splitting between valleys paired by a crystal symmetry.

Pancreatic Spint1 disruption causes glucose intolerance, reduced islet size, and decreased insulin synthesis and secretion. SPINT1 regulates HEPSIN’s modification of GLP1R/MAFA activation, vital for glucose control by β cells, linking it to diabetes.

The heterogeneity of HSPCs in response to IR stress remains poorly characterized. Here, the authors provide insights into the molecular intricacies of IR-induced BM injury and reveal the roles of BMP4-BMPR2 signaling in radiation resistance of HSCs.

The cobalt-catalyzed intermolecular reductive coupling of alkenes and alkynes is attractive due to the unique reactivity and cost-effectiveness of cobalt catalysts. Here, the authors report an asymmetric desymmetric reductive coupling of electronically unbiased succinimide-containing cyclobutenes with internal alkynes via photoredox and cobalt dual catalysis.

Polymer crystals usually grow at conditions far away from thermodynamic equilibrium, but understanding of metastable states within polymer crystals remains limited. Here the authors use selective dissolution to investigate the time- and space-dependent dissolution velocities of polymer crystals and investigate the relation between growth kinetics and the resulting metastability within lamellar polymer single crystals.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

CRISPR-based detection has long been challenged by the separation of amplification and detection steps. In this study, Cheng et al., show that heparin sodium modulates Cas12 cleavage activity and apply a one pot system to detect clinical influenza A virus and SARS-CoV-2 in wastewater.

The synthesis of ionic olefin linked threedimensional covalent organic frameworks (3D COFs) is challenging because of the difficulties in forming stable carbon-carbon double bonds. Here, the authors report a general synthesis of an ionic sp² carbon linked COFs and demonstrate selective capture of ReO₄⁻ ions.

Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

Achieving high-dexterity, multimodal perception at low cost remains a challenge for anthropomorphic hands. Here, authors present an 18-DOF dexterous hand that relies solely on a monocular camera to sense joint angles, contact forces, and object properties without the need for additional sensors.

A study examines functional human endogenous fatty acid synthase and characterizes its structural dynamics using single-particle cryo-electron microscopy, providing insights into its dynamics during the fatty acid synthesis condensing cycle.

Epstein-Barr virus is associated with increased cancer risk. Here, the authors analysed two population-based prospective cohorts in Southern China to examine the association between increased seropositivity and the risk of multiple cancer types.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

The authors present TropiCycloneNet, a framework that combines a multimodal tropical cyclone dataset spanning 70 years and a machine learning forecast model. The approach improves forecast skill of tropical cyclone track and intensity compared to other methods, advancing data-driven weather prediction.

Previous work has shown that electronic and structural transitions in VO₂ can be decoupled by realizing an electronic transition within a monoclinic phase. Here, the authors extend this to the rutile phase by demonstrating a photodoping-driven transition from an insulating to a metallic rutile phase.

The genetic basis of gestational diabetes remains poorly characterised, particularly in non-European populations. Here, the authors identify 13 novel loci and develop an early prediction model integrating polygenic risk scores and prenatal records in Chinese pregnancies.

Chiral metasurfaces have been produced, with experimental observation of intrinsic chiral bound states in the continuum, which may lead to applications in chiral light sources and detectors, chiral sensing, valleytronics and asymmetric photocatalysis.

Understanding how copper nanoparticles evolve under electrochemical conditions is crucial for the development of selective CO₂ reduction electrocatalysts. Here the authors prepare well-defined nanocrystals and use advanced operando imaging and spectroscopic techniques to reveal the Cu–CO species-driven dynamic evolution of Cu electrodes.

The intestinal mucosa presents a complex immune environment requiring a fine balance of immune activity against pathogenic, benign or self antigens. Here the authors show that gut CD4⁻CD8αβ⁻TCRαβ⁺ T (double-negative T/DNT) cells express MHC-II, serve as antigen-presenting cells, and tolerize gut CD4 T cells to help maintain gut immune homeostasis.

Despite the lower device efficiency, tin perovskite based solar cells are preferred choices compared to lead-based counterparts due to much lower toxicity. Here Jiang et al. use a fullerene derivative to greatly suppress carrier interface recombination and obtain record high cell efficiency of 12%.