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Hillside urbanization rises as cities exhaust flat land, threatening sensitive ecosystems. Mapping of 11.65 Mha added since 2000 reveals that 35% of them are in critical areas, fragmenting habitats and endangering 70% of globally threatened species.

(Hetero)aryl sulfoximines are useful bioisosteres of (hetero)aryl sulfones in medicinal chemistry as they have improved aqueous solubility and metabolic stability. Here, the authors report a synthesis of (hetero)aryl sulfoximines via copper-catalysed coupling of (hetero)aryl iodides and sulfenamides.

The bacterial pathogen Legionella pneumophila is known to regulate a wide spectrum of host processes using its Dot/Icm effectors. In this work, He et al. provide insight into L. pneumophila regulation of ATP level in host cells.

The bacterial pathogen Legionella pneumophila secretes effectors that affect protein ubiquitination within host cells, involving production of phosphoribosyl ubiquitin (PR-Ub). Here, the authors identify additional effectors that convert PR-Ub back into functional ubiquitin, thus maintaining ubiquitin homeostasis in infected cells.

Single-atomic impurities may induce novel quantum state, but they are unexplored in topological magnets. Here, the authors report spin-down polarized bound states which further interact with neighboring states to form spin-orbit split quantized orbitals in a topological magnet Co₃Sn₂S₂.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Accurately predicting how much rising atmospheric carbon dioxide can increase rice production is important for managing global rice production. This study highlights that elevated carbon dioxide will boost rice yields more in middle-to-high-income countries than in low-income countries, and that this yield gap will continue to widen in the future.

Chemotherapeutic agents and immune checkpoint inhibitors have shown modest efficacy in patients with advanced biliary tract cancers (BTCs). Here the authors report the results of a phase II trial of the anti-PD1 antibody sintilimab plus chemotherapy (gemcitabine and cisplatin) as first-line treatment for patients with advanced BTCs.

Genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and from 46 present-day groups provide insights into the histories of mixture and migration of human populations in East Asia.

Occult node metastasis is a key staging component of non-small cell lung cancer. Here, the authors use deep learning to improve diagnosis of lymph node metastasis from PET and CT radiomics.

Analysis of copy number alterations in 1,451 patient-derived xenografts (PDXs) and matched patient tumor samples shows strong conservation from patient tumors through late-passage PDXs and a lack of systematic copy number evolution driven by the mouse host.

This study uses satellite radar observations to investigate the triggering and recovery mechanisms of landslides that are accelerated by earthquakes without immediate failures but showing a prolonged response.

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

This article presents a new method for coordinating iridium atoms with dimethylimidazole and cobalt–iron hydroxides. This enhances the oxygen evolution reaction and delivers high current densities with reduced precious metal use.

A large spin Hall angle and long spin diffusion length are found in the low-symmetry, few-layer semimetal MoTe₂ at room temperature, thus identifying this material as an excellent candidate for simultaneous spin generation, transport and detection.

Patient-derived xenograft models (PDX) have been extensively used to study the molecular and clinical features of cancers. Here the authors present a cohort of 536 PDX models from 25 cancers, as well as their genomic and evolutionary profiles and their suitability for clinical trials.

The reversible transformation of a nanohelix is one of the most exquisite and important phenomenon in nature but nanomaterials usually fail to twist into helical crystals or untwist. Here, the authors report a reciprocal effect between molecular geometry and crystal structure which triggers a twisting-untwisting-retwisting cycle for tri-cobalt salicylate hydroxide hexahydrate.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.

A synthesis of global change experiments that manipulated temperature, precipitation, carbon dioxide or nitrogen identifies a need to consider site-specific factors and interactions in Earth system models.

Well-dispersed nanoparticles are critical for catalysis but face challenges of easy agglomeration. Here the authors report synthesis of ultrasmall nanoparticles anchored on two-dimensional porous carbon via coordinated carbothermal shock and the application of resulted nanoparticles as catalysts for oxygen electrocatalysis.

Components for flexible electronics capable of both bending and stretching have been reported but the fabrication of similarly pliable power sources remains challenging. Here, the authors present stretchable lithium ion batteries exploiting segmented layouts and deformable electrical interconnects.

The integration of omics analyses of primary glomerular diseases with data from clinical and histopathological studies is expected to advance our understanding of the molecular basis of these diseases and lead to improvements in diagnosis and treatment. Here, the authors provide an up-to-date overview of omics studies of primary glomerular diseases and suggest new approaches to further characterize their pathogenetic mechanisms, candidate genes, potential biomarkers and therapeutic targets.

The small molecule Bis-T-23 targets actin polymerization to improve renal morphology and function in several mouse models of kidney injury and disease.

Tumor–normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking ‘tumor-only’ or ‘matched tumor–normal’ analyses.

A Study Identifies Broad-Spectrum Pan-Coronavirus Antiviral Drugs Targeting Host Protein Quality Control Mechanisms And Reports Development Of A Bsl2-Level Cell-Integrated Sars-Cov-2 Replicon, Which Can Be Used For High-Throughput Screening.