Nature Search

Author Correction: Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Chunlong Xu
Yingsi Zhou
Hui Yang
Amendments and Corrections02 Jan 2022
Nature Methods

Volume: 19, P: 255
Author Correction: Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

Guoling Li
Xue Dong
Yingsi Zhou
Amendments and CorrectionsOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1
NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation

Rapid detection of diverse biomarkers is crucial for public health. Here, the authors develop NAPTUNE, a versatile platform that identifies multiple nucleic acids and proteins targets within 45 minutes using a nuclease cascade.

Tao Hu
Xinxin Ke
Chunyi Hu
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-16
Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

This work describes the identification of Cas13 proteins from two families by mining public metagenomic data. The newly identified Cas13X.1 shows efficient target knockdown and can be used to degrade SARS-CoV-2 and H1N1 genomes. In addition, the truncated Cas13X.1 offers an advantage in generating mini-RNA base editors.

Chunlong Xu
Yingsi Zhou
Hui Yang
Research03 May 2021
Nature Methods

Volume: 18, P: 499-506
Reference genome assemblies reveal the origin and evolution of allohexaploid oat

A reference-quality genome assembly of hexaploid oat variety ‘Sanfensan’ and genome assemblies of its diploid and tetraploid Avena ancestors provide insights into the evolutionary history of allohexaploid oat.

Yuanying Peng
Honghai Yan
Changzhong Ren
ResearchOpen Access18 Jul 2022
Nature Genetics

Volume: 54, P: 1248-1258
Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase

A base editor is engineered for A-to-T and A-to-C transversion editing.

Huawei Tong
Xuchen Wang
Hui Yang
Research09 Jan 2023
Nature Biotechnology

Volume: 41, P: 1080-1084
Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

Engineered TadA variants in cytosine base editors (CBEs) offer advantages like smaller size and reduced off-target effects. Here, authors develop an advanced CBE (aTdCBE) through ortholog screening and protein engineering, successfully enabling exon skipping in Duchenne muscular dystrophy model.

Guoling Li
Xue Dong
Yingsi Zhou
ResearchOpen Access16 Sept 2024
Nature Communications

Volume: 15, P: 1-10
An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates

Duplication of the MECP2 gene (encoding methyl-CpG-binding protein 2) causes MECP2 duplication syndrome. Here the authors develop a Cas13Y system capable of targeting the MECP2 mRNA for degradation and reducing protein levels in the brain of humanized MECP2-transgenic mice and nonhuman primates.

Dong Yang
Xiaoqing Wu
Hui Yang
Research12 Dec 2024
Nature Neuroscience

Volume: 28, P: 72-83
Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model

Duchenne muscular dystrophy (DMD) results from mutations in the DMD. Here the authors report using adenine base editing of exon splice sites to restore dystrophin expression and muscle function in a humanized mouse model of DMD with exon 50 and 51 of mouse DMD gene replaced with human exon 50.

Jiajia Lin
Ming Jin
Guoling Li
ResearchOpen Access15 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Pangenome analysis provides insight into the evolution of the orange subfamily and a key gene for citric acid accumulation in citrus fruits

De novo genome assemblies of 12 species from Aurantioideae and pangenome analyses provide insights into the origin and evolution of the orange subfamily and the genetic basis of flavor in citrus fruits.

Yue Huang
Jiaxian He
Qiang Xu
Research02 Oct 2023
Nature Genetics

Volume: 55, P: 1964-1975
Global freshwater fish invasion linked to the presence of closely related species

Whether non-native species are more or less likely to become established in communities that host close relatives is debated. This global study shows that non-native fish species phylogenetically close to native species are more likely to establish in freshwater ecosystems.

Meng Xu
Shao-peng Li
Xidong Mu
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-11
Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model

Miniature gene editing tools are highly desired for efficient in vivo delivery and disease treatment. Here, the authors reported engineering hypercompact TnpB-ωRNA for robust gene editing with minimal off-target effect in cultured cells and use it to rescue fatal genetic liver disease in a tyrosinaemia mouse model.

Zhifang Li
Ruochen Guo
Chunlong Xu
ResearchOpen Access27 Jan 2024
Nature Communications

Volume: 15, P: 1-11
Focusing on DC cells to optimize the prediction of prognosis and innovative treatment strategies for colon cancer

Chaobo Chen
Zhengqiu Wang
Yihang Yuan
ResearchOpen Access19 May 2025
Scientific Reports

Volume: 15, P: 1-16
Graph-enhanced implicit aspect-level sentiment analysis based on multi-prompt fusion

Xu Li
Xinlong Wang
Yang Li
ResearchOpen Access20 May 2025
Scientific Reports

Volume: 15, P: 1-19
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Several engineered Cas13 variants achieve targeted RNA degradation with minimal collateral effects.

Huawei Tong
Jia Huang
Hui Yang
Research11 Aug 2022
Nature Biotechnology

Volume: 41, P: 108-119
Enabling fast-charging selenium-based aqueous batteries via conversion reaction with copper ions

Aqueous battery Se-based cathodes are based on a two-electron transfer electrochemical reaction and generally show inadequate rate capability behaviour. Here, the authors propose a four-electron Se chemistry with copper ions as charge carriers to enable fast-charging battery cycling.

Chunlong Dai
Linyu Hu
Liangti Qu
ResearchOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-10
Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

CRISPR screens identify JNK–JUN family genes as repressors of definitive endoderm differentiation in human pluripotent stem cells. JUN co-occupies stem cell enhancers with OCT4, NANOG, SMAD2 and SMAD3 and inhibits the exit from pluripotency.

Qing V. Li
Gary Dixon
Danwei Huangfu
Research20 May 2019
Nature Genetics

Volume: 51, P: 999-1010
The LncRNA Connectivity Map: Using LncRNA Signatures to Connect Small Molecules, LncRNAs, and Diseases

Haixiu Yang
Desi Shang
Xia Li
ResearchOpen Access27 Jul 2017
Scientific Reports

Volume: 7, P: 1-6
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

Xiao Xiao
Jiankai Liang
Guangmei Yan
ResearchOpen Access18 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance

Jiantao Zhang
Yanmei Hu
Jun Wang
ResearchOpen Access15 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
Tightly bound and room-temperature-stable excitons in van der Waals degenerate-semiconductor Bi₄O₄SeCl₂ with high charge-carrier density

Excitons – electron-hole bound states important for optoelectronics – are typically observed only in weakly-doped semiconductors or insulators. Here, an exciton with a large binding energy of 375 meV is observed in a highly-doped van der Waals degenerate semiconductor, remaining stable up to room temperature.

Yueshan Xu
Junjie Wang
Zhi-Guo Chen
ResearchOpen Access04 Sept 2023
Communications Materials

Volume: 4, P: 1-10
Ptbp1 knockdown failed to induce astrocytes to neurons in vivo

Guixiang Yang
Zixiang Yan
Kailun Fang
Research01 Feb 2023
Gene Therapy

Volume: 30, P: 801-806
Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

Yinghui Wei
Chunlong Xu
Meiling Zhang
CorrespondenceOpen Access01 Feb 2022
Cell Discovery

Volume: 8, P: 1-4
High-throughput proteomic sample preparation using pressure cycling technology

High-throughput lysis and proteolytic digestion of biopsy-level tissue specimens is a major bottleneck for clinical proteomics. This protocol describes pressure cycling technology (PCT)-assisted sample preparation of biopsy tissues.

Xue Cai
Zhangzhi Xue
Tiannan Guo
Protocols05 Aug 2022
Nature Protocols

Volume: 17, P: 2307-2325
Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

This study presents a novel Type I-A CRISPR-Cas3 variant for precise HPV diagnosis. It demonstrates dual activation modes and robustness without stand-alone Cas3 activity, enhancing CRISPR-Cas3 diagnostic applications.

Tao Hu
Quanquan Ji
Chunyi Hu
ResearchOpen Access13 Jul 2024
Communications Biology

Volume: 7, P: 1-12
Global Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network

Qianlan Yao
Yanjun Xu
Xia Li
ResearchOpen Access24 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis

Junwei Han
Xinrui Shi
Xia Li
ResearchOpen Access12 Aug 2015
Scientific Reports

Volume: 5, P: 1-15
LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method

Junwei Han
Siyao Liu
Xia Li
ResearchOpen Access20 Apr 2017
Scientific Reports

Volume: 7, P: 1-14
Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case

Wei Liu
Xuefeng Bai
Chunquan Li
ResearchOpen Access19 Aug 2015
Scientific Reports

Volume: 5, P: 1-15
Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos

Yinghui Wei
Zhifang Li
Erwei Zuo
CorrespondenceOpen Access18 Mar 2022
Cell Discovery

Volume: 8, P: 1-4
In vivo treatment of tyrosinaemia with hypercompact Cas12f1

Ruochen Guo
Zhifang Li
Chunlong Xu
CorrespondenceOpen Access18 Jul 2023
Cell Discovery

Volume: 9, P: 1-4

Search

Author Correction: Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Author Correction: Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation

Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Reference genome assemblies reveal the origin and evolution of allohexaploid oat

Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase

Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates

Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model

Pangenome analysis provides insight into the evolution of the orange subfamily and a key gene for citric acid accumulation in citrus fruits

Global freshwater fish invasion linked to the presence of closely related species

Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model

Focusing on DC cells to optimize the prediction of prognosis and innovative treatment strategies for colon cancer

Graph-enhanced implicit aspect-level sentiment analysis based on multi-prompt fusion

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Enabling fast-charging selenium-based aqueous batteries via conversion reaction with copper ions

Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

The LncRNA Connectivity Map: Using LncRNA Signatures to Connect Small Molecules, LncRNAs, and Diseases

DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance

Tightly bound and room-temperature-stable excitons in van der Waals degenerate-semiconductor Bi₄O₄SeCl₂ with high charge-carrier density

Ptbp1 knockdown failed to induce astrocytes to neurons in vivo

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

High-throughput proteomic sample preparation using pressure cycling technology

Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

Global Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network

ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis

LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method

Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case

Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos

In vivo treatment of tyrosinaemia with hypercompact Cas12f1

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