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The interplay between coherent wave-like and incoherent particle-like transport can lead to environment-assisted quantum transport. Using time resolved microscopies and theoretical modeling, the authors show signatures of this enhanced transport regime in perovskite nanocrystal superlattices.

We report the outcome of an international optical observation campaign of a prototype constellation satellite, AST SpaceMobile’s BlueWalker 3, which features a 64.3 m² phased-array antenna and a launch vehicle adaptor.

The function of TRPA1 channels in the mammalian cochlea is poorly understood. Here, the authors show that TRPA1 channels in supporting cells of the organ of Corti mediate contractile responses that may contribute to temporary shifts in hearing thresholds after noise exposure in mice.

Soil rhizobial bacteria need entry into legume roots to fulfil symbiotic nitrogen fixation, which is important for sustainable agriculture. Zhao et al. report how legumes control this entry through plant cell wall changes mediated by host cellulases.

A recently discovered high-mass X-ray binary has an evolutionary history showing the neutron star component formed during an ultra-stripped supernova, and has orbital elements that should allow for forming a binary neutron star in the future.

Absorption by an optical nanoantenna determines its interaction strength with light, yet this quantity is hidden from conventional spectroscopy. Gennaro et al. now demonstrate a spectroscopic technique that reveals a nanoantenna’s absorption by recovering its amplitude and phase response.

Material from the Hokioi crater on asteroid Bennu experienced space weathering and suggests microcratering plays a more active role on carbonaceous bodies than initially thought, according to a study of OSIRIS-REx asteroid return samples.

In this Review, the authors describe the diversity and characteristics of tissue-resident human natural killer cells, with focus on those found in the liver, uterus and lungs. They also discuss important unresolved questions and future challenges in the field.

Becker et al. use live imaging of SARS-CoV-2 infected airway epithelium cultures to demonstrate a dual role for mucociliary clearance in viral spread. Initially, virus goes with the mucus flow, facilitating local spread; later, increased mucus secretion and ciliary motion defects limit spread.

Hyper-complex quantum theories are generalizations of quantum mechanics where amplitudes are generalized complex numbers. Here the authors study phase commutation in a photonic experiment, reporting consistency with standard quantum mechanics and placing precise bounds on hyper-complex theories.

A black hole at the centre of a quasar at a redshift of z = 4 is accreting the mass of the Sun every day. The quasar’s extreme luminosity is equivalent to 50,000 times that of the Milky Way. Its broad-line region should be resolvable observationally and will provide an important test for broad-line region size–luminosity relationships.

'Spaghetti monster' fluorescent proteins combine the power of conventional fluorescent proteins with the benefits of commonly used epitopes. These probes are demonstrated to be extremely versatile in diverse imaging applications.

Increasing nanoparticle size usually increases the stability of ordered phases within them. In contrast, the authors show here that the L1₁ ordered phase only forms in AgPt nanoparticles smaller than 2.5 nm because the segregation of a monolayer Ag shell constrains the nanophase which becomes unstable at larger sizes.

The function of the first proteins that mediate adhesion of Leishmania parasites to its sand fly vector are reported. Loss of these proteins stops parasite adhesion, reducing physiological changes to the fly that will likely impact transmission.

Animals alternate between active periods and periods of rest or sleep. This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells interacting with neurons links brain function with the need for rest and sleep.

Here the authors made lipid-based CCR5-receptor targeted nanoparticles to facilitate cell-based delivery of the antiretroviral drug rilpivirine, improving HIV-1 suppression in cell and tissue reservoirs. Focused ultrasound facilitates penetrance of the nanoparticles across the blood-brain barrier where they enter myeloid cells in humanized mice.

Observations from the JWST MIRI-MRS instrument reveal the detection of rotational emission from molecular hydrogen near the only O-type star in the 3% solar metallicity galaxy Leo P, providing confirmation that significant quantities of molecular gas can form in such metal- and dust-poor environments.

In astronomy, interferometry between telescopes enables high-resolution imaging but optical links are limited by atmospheric turbulence. Here, the authors show how this can be circumvented, producing diffraction-limited images using an array of electronically connected optical telescopes.

STED nanoscopy enables sub-diffraction imaging with a wide range of fluorescent probes. Here, the authors show that a bright and very photostable class of fluorescent quantum dots can be super-resolved with STED as biolabels in cellular contexts.

A method that uses a combination of optical trapping, fluorescence microscopy and microfluidics to analyse the internal structure of chromosomes shows that there is a distinct nonlinear stiffening of the chromosome in response to tension.

Using complementary live cell approaches together with a powerful in vitro reconstitution system, this study demonstrates the direct regulation of mitochondrial dynamics by localized changes to the lipid composition of the outer membrane.

The electronic band structure of atomically thin transition metal dichalcogenides is strongly sensitive to the number of layers, resulting in modified light emission. Here, the authors investigate the cryogenic emission from bilayer WSe₂ to identify the role of momentum-indirect excitons for its optical response.

Venus is covered by thick clouds that move with the prevailing winds. Images from JAXA’s Akatsuki orbiter taken in July 2016 reveal more variability deep in the cloud layer than expected, including a feature consistent with an equatorial jet.

Individually addressed rare earth atoms in solid crystals are an emerging platform for quantum information processing. Here the authors demonstrate a key requirement, by realizing single-shot, quantum non-demolition measurements of the spin of single Er³⁺ ions in Y₂SiO₅ crystals with nearly 95% fidelity.

Liquid–liquid phase separation is known in cell biology as an underlying mechanism of intracellular organization. The authors study a complex interplay between phase separation, network mechanics, and condensate capillarity, providing explanation for the phenomena in complex environments like the cellular interior.

JWST reveals the chemistry of the disk of a young star in the Orion nebula, showing that it has water and CO in its inner regions that are shielded from UV radiation, whereas UV-processed molecules such as CH₃⁺ and PAHs are detected in surface layers.

Foetal haematopoiesis takes place in the liver before the bone marrow is seeded. Here the authors used imaging analysis and mouse genetics to look at nascent bone marrow formation and show that yolk-sac-derived myeloid cells promote haematopoiesis by promoting specification of a VCAM1⁺ sinusoidal colonisation niche.

Topobiologically complex mini-colons—which enable the faithful in vitro recapitulation of colorectal cancer tumorigenesis and its environmental determinants—offer the possibility to reduce animal use in a wide range of experimental applications.

Epithelial-mesenchymal transition (EMT) plays a key role in embryonic development, wound healing and cancer. Here the authors develop an electrochemical sensor to detect EMT using E-cadherin antibody-quantum dot conjugates and a carbon nanotube-gold nanoparticle-modified electrode as a detection platform.

Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

Dysregulated immune features in a patient with a homozygous loss-of-function mutation in PDCD1 suggest that IL-6, IL-23, STAT3 and RORγT might be potential targets for treatment of PD-1 blockade-induced autoimmunity.

On-surface synthesis of two-dimensional polymers is a useful strategy for designing the lattice, orbital and spin symmetries of materials, but controlling their layer stacking remains challenging. Now, a method to synthesize bilayer two-dimensional covalent organic frameworks at a liquid–substrate interface through monomer condensation has been developed; large-area moiré superlattices emerge from the twisted bilayer stacking.

Small clusters of magnetic atoms can behave in very different ways to those same atoms in bulk. Arranging iron atoms one by one into complex but well-defined patterns on a copper surface enables the construction of nanoscale magnetic structures with tailored characteristics.

A study reports the measurement of the polarization degree and angle of X-rays from Sagittarius A^* reflected off a nearby cloud, indicating an X-ray flare about 200 years ago.

In people with severe brain injuries, stimulation restored consciousness by engaging a deep brain circuit for wakefulness—revealing a target that may also guide treatment in stroke and epilepsy.

Propagation losses have limited the practical use of polaritons in photonic applications. Here the authors demonstrate a substantial enhancement in the propagation distance of phonon polaritons, employing synthetic optical excitation of complex frequency with virtual gain synthesized by combining multiple real frequency measurements.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

Spectroscopy from the JWST Advanced Deep Extragalactic Survey of a galaxy at redshift 13 shows a singular, bright emission line identified as Lyman-α, suggesting the onset of reionization only 330 Myr after the Big Bang.

Surgical nerve injuries can cause significant morbidity, yet no approved fluorescent agents exist for visualization. Here, the authors show in a Phase I multi-site trial that bevonescein was safe, established optimal dosing and timing, and provided a fluorescence signal for intraoperative nerve identification.