Nature Search

Experimental constraints on strong-field relativistic gravity

J. H. Taylor
A. Wolszzan
J. M. Weisberg
Research09 Jan 1992
Nature

Volume: 355, P: 132-136
Orbits of shepherd satellites deduced from the structure of the rings of Uranus

Carl D. Murray
Robert P. Thompson
Research06 Dec 1990
Nature

Volume: 348, P: 499-502
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Photon number statistics uncover the fluctuations in non-equilibrium lattice dynamics

Fluctuations of atomic positions are related to several materials properties. Here the authors measure the photon number statistics via a non-equilibrium optical experiment and provide a quantum description of the interaction between photonic and phononic fields to reveal lattice dynamics fluctuations in quartz.

Martina Esposito
Kelvin Titimbo
Daniele Fausti
ResearchOpen Access22 Dec 2015
Nature Communications

Volume: 6, P: 1-7
Exome analysis links kidney malformations to developmental disorders and reveals causal genes

The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, along with 38 candidate genes, providing evidence for shared genetics with other developmental disorders.

Hila Milo Rasouly
Sarath Babu Krishna Murthy
Ali G. Gharavi
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Histopathology-based protein multiplex generation using deep learning

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

Sonali Andani
Boqi Chen
Gunnar Rätsch
ResearchOpen Access04 Aug 2025
Nature Machine Intelligence

Volume: 7, P: 1292-1307
Laboratory model of a planetary eastward jet

Joël Sommeria
Steven D. Meyers
Harry L. Swinney
Research05 Jan 1989
Nature

Volume: 337, P: 58-61
Filopodia are essential for steroid release

Here they show that specialized filopodia are essential for steroid hormone secretion in fruit flies, highlighting a vesicle-mediated mechanism adjusted by filopodia dynamics that challenges a simple secretory diffusion model.

Eléanor Simon
Raphaël Bonche
Nuria Magdalena Romero
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Condensing and constraining WNT by TGF-β

TGF-β can antagonise or cooperate with WNT signalling, yet it is still unclear what mechanisms integrate the outcomes of these conserved pathways. A new study now reports that the formation of biomolecular condensates, dependent on the DACT1 protein, provides the spatial segregation needed for TGF-β to constrain WNT signalling.

Kiran D. Patel
Don X. Nguyen
News & Views09 Mar 2021
Nature Cell Biology

Volume: 23, P: 213-214
Intrachromosomal gene conversion in yeast

Hannah L. Klein
Thomas D. Petes
Research15 Jan 1981
Nature

Volume: 289, P: 144-148
Construction of a mouse yeast artificial chromosome library in a recombination–deficient strain of yeast

F. L. Chartier
J. T. Keer
S. D. M. Brown
Research01 May 1992
Nature Genetics

Volume: 1, P: 132-136
PARP inhibitors: a treatment option for AML?

A new study provides a rationale for the use of poly (ADP-ribose) polymerase (PARP) inhibitors to trigger irreparable DNA damage as a therapeutic approach in acute myeloid leukemia (AML). It also provides support for combining PARP inhibitors with agents that reduce HOXA9 protein levels.

Lan Wang
Pierre-Jacques Hamard
Stephen D Nimer
News & Views08 Dec 2015
Nature Medicine

Volume: 21, P: 1393-1394
The Prasinomycins: Antibiotics containing Phosphorus

FRANK L. WEISENBORN
JACQUELINE L. BOUCHARD
EDWARD MEYERS
Research01 Mar 1967
Nature

Volume: 213, P: 1092-1094
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer

Rudalska et al. describe a novel class of p38α inhibitors with increased target residence time. They explore the drugs’ specificity, pharmacokinetics and toxicity profile and show that they are efficacious in the context of colorectal cancer.

Ramona Rudalska
Jule Harbig
Daniel Dauch
ResearchOpen Access16 Jan 2025
Nature Cancer

Volume: 6, P: 259-277
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and chromatin to regulate mechanosensitive genes.

Ruhul Amin
Anjali Shukla
Kent W. Hunter
ResearchOpen Access13 Dec 2021
Nature Communications

Volume: 12, P: 1-23
Feasibility of multiomics tumor profiling for guiding treatment of melanoma

In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

Nicola Miglino
Nora C. Toussaint
Andreas Wicki
ResearchOpen Access27 May 2025
Nature Medicine

Volume: 31, P: 2430-2441
Homoeo-domain homology in yeast MATα2 is essential for repressor activity

Susan D. Porter
Michael Smith
Research24 Apr 1986
Nature

Volume: 320, P: 766-768
A synaptobrevin–like gene in the Xq28 pseudoautosomal region undergoes X inactivation

Maurizio D'Esposito
Alfredo Ciccodicola
Michele D'Urso
Research01 Jun 1996
Nature Genetics

Volume: 13, P: 227-229
ROCK-dependent mechanotransduction of macroscale forces drives fibrosis in degenerative spinal disease

In human spinal ligament tissue exposed to high stress, fibrotic regions displaying elevated Rho-associated kinase signalling and an increased density of myofibroblasts expressing smooth muscle actin α contribute to degenerative spinal disease.

Muhamed Hadzipasic
Margaret S. Sten
Ganesh M. Shankar
Research29 May 2025
Nature Biomedical Engineering

P: 1-14
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia

The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

Rebekka Wegmann
Ximena Bonilla
Alexandre P. A. Theocharides
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Oxyfunctionalization of alkanes with hydrogen peroxide on titanium silicalite

D. R. C. Huybrechts
L. De Bruycker
P. A. Jacobs
Research17 May 1990
Nature

Volume: 345, P: 240-242
Optimal bone-implant contact sites in the zygomatic region for quad zygomatic implants placement: a retrospective study in Vietnamese patients on CBCT

Mi Nguyen-Tra Le
Tri Minh Tran
Lam Hung Tran
ResearchOpen Access20 Jun 2025
BDJ Open

Volume: 11, P: 1-7
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

Multidrug resistance of the opportunistic pathogen Stenotrophomonas maltophilia is an increasing problem. Here, analyzing strains from 22 countries, the authors show that the S. maltophilia complex is divided into 23 monophyletic lineages and find evidence for intra-hospital transmission.

Matthias I. Gröschel
Conor J. Meehan
Thomas A. Kohl
ResearchOpen Access27 Apr 2020
Nature Communications

Volume: 11, P: 1-12
An atypical topoisomerase II from archaea with implications for meiotic recombination

Agnès Bergerat
Bernard de Massy
Patrick Forterre
Research27 Mar 1997
Nature

Volume: 386, P: 414-417
Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma

Nicola Miglino
Nora C. Toussaint
Andreas Wicki
Amendments and CorrectionsOpen Access01 Aug 2025
Nature Medicine

Volume: 31, P: 2817-2818
Identification of the UV nightglow from Venus

P. D. FELDMAN
H. W. MOOS
A. L. LANE
Research17 May 1979
Nature

Volume: 279, P: 221-222
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

Krzysztof Kiryluk
Elena Sanchez-Rodriguez
Ali G. Gharavi
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1091-1105
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Andreas Meyer-Lindenberg
Robert S. Miletich
Karen Faith Berman
Research28 Jan 2002
Nature Neuroscience

Volume: 5, P: 267-271
Warm gas in the vicinity of a supermassive black hole 13 billion years ago

ALMA observations have established the presence of warm, X-ray-heated gas near a supermassive black hole at redshift z = 6, demonstrating that highly excited CO lines are a powerful method for exploring heavily dust-obscured quasars in the early Universe.

K. Tadaki
F. Esposito
T. Michiyama
Research07 Mar 2025
Nature Astronomy

Volume: 9, P: 720-728
What is the optimal laparoscopic antireflux procedure for children with gastroesophageal reflux disease?

Donald Liu
Irving Waxman
Comments & Opinion01 Jan 2007
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 4, P: 14-15
The neural basis of the central executive system of working memory

Mark D'Esposito
John A. Detre
Murray Grossman
Research16 Nov 1995
Nature

Volume: 378, P: 279-281
Cryo-EM structure of a RAS/RAF recruitment complex

RAF kinases are autoinhibited in the cytosol and are activated by recruitment to the plasma membrane by GTP-bound RAS. Here, the authors describe cryoEM structures of a membrane-free KRAS/BRAF/MEK/14-3-3 complex that capture a pre-activation intermediate with BRAF still in an autoinhibited state.

Eunyoung Park
Shaun Rawson
Michael J. Eck
ResearchOpen Access29 Jul 2023
Nature Communications

Volume: 14, P: 1-11
External Effect of Indolyl-3-acetic Acid, Benzimidazole and B-nine on Nodulation of Cowpea

D. MISHRA
B. MOHANTY
Research15 Apr 1967
Nature

Volume: 214, P: 320-321
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1

Cryo-EM and three-dimensional variability analyses reveal the structure of the autoinhibited 640-kDa NF1 dimer, providing a long-sought-after molecular explanation for the extreme sensitivity of the NF1 gene to loss-of function mutation in disease.

Christopher J. Lupton
Charles Bayly-Jones
Andrew M. Ellisdon
Research09 Dec 2021
Nature Structural & Molecular Biology

Volume: 28, P: 982-988
ASL reveals regional brain perfusion impairment in neonates with mild hypoxic ischemic encephalopathy

Mario Cirillo
Simona Puzone
Paolo Montaldo
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Isolating the neural mechanisms of age-related changes in human working memory

Bart Rypma
Mark D'Esposito
Research01 May 2000
Nature Neuroscience

Volume: 3, P: 509-515
Integrated multimodal cell atlas of Alzheimer’s disease

The affected cellular populations during Alzheimer’s disease progression remain understudied. Here the authors use a cohort of 84 donors, quantitative neuropathology and multimodal datasets from the BRAIN Initiative. Their pseudoprogression analysis revealed two disease phases.

Mariano I. Gabitto
Kyle J. Travaglini
Ed S. Lein
ResearchOpen Access14 Oct 2024
Nature Neuroscience

Volume: 27, P: 2366-2383
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation

Mutations in RAS and PI3Kα drive cancer by activating the PI3K-AKT-mTOR pathway. The authors present RAS-PI3Kα structures, revealing interaction interfaces, isoform-specific differences, and a framework for designing PI3Kα-specific inhibitors.

Daniel Czyzyk
Wupeng Yan
Dhirendra K. Simanshu
ResearchOpen Access09 Jan 2025
Nature Communications

Volume: 16, P: 1-19
A cross-species proteomic map reveals neoteny of human synapse development

A study presents a cross-species proteomic map of synapse development in neocortex and reveals that the human postsynaptic density assembly develops two to three times slower than that in macaques and mice.

Li Wang
Kaifang Pang
Arnold R. Kriegstein
Research13 Sept 2023
Nature

Volume: 622, P: 112-119
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

The involvement of cell death pathways in the early stage of pancreatic ductal adenocarcinoma (PDAC) development, especially KRAS-dependent acinar-to-ductal metaplasia (ADM), remains to be investigated. Here, the authors find that TAK1 mediates cell survival during ADM transdifferentiation through suppression of apoptosis and necroptosis, which could be targeted for prevention and treatment of PDAC.

Anne T. Schneider
Christiane Koppe
Tom Luedde
ResearchOpen Access19 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Inhibition of exocytosis by intracellularly applied antibodies against a chromaffin granule-binding protein

Felix E. Schweizer
Theo Schäfer
Max M. Burger
Research27 Jul 1989
Nature

Volume: 340, P: 322
Database-independent molecular formula annotation using Gibbs sampling through ZODIAC

To infer a previously unknown molecular formula from mass spectrometry data is a challenging, yet neglected problem. Ludwig and colleagues present a network-based approach to ranking possible formulas.

Marcus Ludwig
Louis-Félix Nothias
Sebastian Böcker
Research13 Oct 2020
Nature Machine Intelligence

Volume: 2, P: 629-641
D-aspartate exerts an opposing role upon age-dependent NMDAR-related synaptic plasticity and memory decay

Francesco Errico
Robert Nistico’
Alessandro Usiello
ResearchOpen Access15 May 2008
Nature Precedings

P: 1
Metabolic Differences between Starch and Sucrose

SOHAIR AL-NAGDY
D. S. MILLER
JOHN YUDKIN
Research01 Jan 1966
Nature

Volume: 209, P: 81-82
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools to identify new binding pockets and pharmacophores.

Katarzyna Z. Haza
Heather L. Martin
Darren C. Tomlinson
ResearchOpen Access30 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Consensus on acromegaly therapeutic outcomes: an update

In this Consensus Statement, an international group of experts provide updated recommendations on the treatment of acromegaly, including discussion of treatment outcomes.

Shlomo Melmed
Luigi di Filippo
Andrea Giustina
Reviews13 Aug 2025
Nature Reviews Endocrinology

Volume: 21, P: 718-737
Human-machine in the vortex of digital synergy

Vaclav Moravec
Beata Gavurova
Martin Rigelsky
ResearchOpen Access20 May 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-13
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Thorsten Heinzel
Robert M. Lavinsky
Michael G. Rosenfeld
Research01 May 1997
Nature

Volume: 387, P: 43-48
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

Simon T. Bennett
Amanda J. Wilson
John A. Todd
Research01 Nov 1997
Nature Genetics

Volume: 17, P: 350-352

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